Contributors

Sasha Mushegian

Sasha Mushegian
Sasha Mushegian is a postdoctoral fellow at Georgetown University. Follow her on Twitter.

Articles by Sasha Mushegian

From the journals: April 2019
Journal News

From the journals: April 2019

4/1/2019
What structural features of a cortisol-producing enzyme could help in treating Cushing’s disease? Can melatonin be used to treat obesity? How does a gut pathogen evade antibiotic treatment? These and other questions are addressed in our roundup.
JBC: Molecules from breast milk and seaweed suggest strategies for controlling norovirus
Journal News

JBC: Molecules from breast milk and seaweed suggest strategies for controlling norovirus

3/1/2019
Researchers from universities in Germany write in the Journal of Biological Chemistry that a dietary supplement of fucose, a sugar molecule found in both breast milk and seaweed, might be useful against norovirus.
JBC: Scanning thousands of molecules against an elusive cancer target
Journal News

JBC: Scanning thousands of molecules against an elusive cancer target

2/1/2019
The enzyme NSD2, overactive in certain cancers, is hard to work with. Researchers at NCATS have a new system to screen for NSD2 inhibitors.
From the journals: February 2019
Journal News

From the journals: February 2019

2/1/2019
How do plants survive in fluctuating temperatures? Why do some of infection-fighting molecules block viruses from entering cells, while others interfere with viral replication? How does a bacterium’s spore coating help it resist antibiotics? 
Journal News

JBC: A molecular dance of phospholipid synthesis

1/1/2019
Research published in the Journal of Biological Chemistry used computer simulations to gain insights into how an enzyme activates and shuts off the production of phosphatidylcholine, commonly known as lecithin.
From the journals: January 2019
Journal News

From the journals: January 2019

1/1/2019
What’s the link between chronic diabetes and cognitive decline? How does the body protect the liver during periods of fasting? Why do some pain drugs work in rodents but not in people?
JBC: A plant immune system corrects its course
Journal News

JBC: A plant immune system corrects its course

12/1/2018
Researchers have identified a crucial link between gene expression and the process by which plants regulate their antiviral responses.
JBC: Seeking an off switch for celiac disease
Journal News

JBC: Seeking an off switch for celiac disease

12/1/2018
A Stanford University team writes in the Journal of Biological Chemistry that they have discovered how a disease-associated protein gets inactivated, opening the door to possible new treatments for this autoimmune disordered triggered by gluten.
From the journals: December 2018
Journal News

From the journals: December 2018

12/1/2018
How early screening can help cure a rare genetic disease in newborns. The connection of genes, brains and immune cells in a risk factor for obesity. The difference between white and brown fat cells. Read about this research and more in our roundup o…
JBC: What happens to plasmalogens, the phospholipids nobody likes to think about
Journal News

JBC: What happens to plasmalogens, the phospholipids nobody likes to think about

11/1/2018
Alzheimer’s patients lose up to 60 percent of plasmalogens from the membranes of brain cells. These molecules are difficult to work with, but painstaking research has revealed the protein that catalyzes their breakdown.
Journal of Biological Chemistry celebrates Herb Tabor’s 100 years
Journal News

Journal of Biological Chemistry celebrates Herb Tabor’s 100 years

11/1/2018
The Maryland county that is home to the National Institutes of Health has declared a day to honor Tabor, who served as editor-in-chief of the Journal of Biological Chemistry for almost 40 years. JBC also has some big celebration plans.
From the journals: November 2018
Journal News

From the journals: November 2018

11/1/2018
Using mass spectrometry to learn how a flexible fish evolved. Finding the anti-addictive enzyme in an African shrub. Tracing how cholesterol contributes to macular degeneration. Read about this research and more in our roundup of recent papers fro…
JBC: Iron–sulfur cluster research offers new avenues for investigating disease
Journal News

JBC: Iron–sulfur cluster research offers new avenues for investigating disease

11/1/2018
Disruptions in the construction of these clusters can lead to buildup of fat droplets in certain cells, providing clues about the causes of nonalcoholic fatty liver disease and clear-cell renal carcinoma.
JBC: Scientists fill in a piece of the copper transport puzzle
Journal News

JBC: Scientists fill in a piece of the copper transport puzzle

10/1/2018
Mitochondria need copper to produce energy. Researchers in the U.S. and Canada report in the Journal of Biological Chemistry that they have identified the protein that performs the tricky task of carrying copper on the correct pathway.
JBC: What bacteria can teach us about combating atrazine contamination
Journal News

JBC: What bacteria can teach us about combating atrazine contamination

10/1/2018
Atrazine is a controversial pesticide. Researchers in Australia write in the Journal of Biological Chemistry that newly discovered proteins involved in its degradation may provide insights into how bacteria respond to chemicals synthesized by humans.
From the journals: October 2018
Journal News

From the journals: October 2018

10/1/2018
A gene that can both increase and decrease diabetes risk. A protein that makes tumor cells more aggressive. Citrus compounds that reverse obesity. Read about these topics and more in our roundup of recent papers from the Journal of Biological Che…
JBC: New insights into the molecular weapons of the plant microbiome
Journal News

JBC: New insights into the molecular weapons of the plant microbiome

9/1/2018
Researchers in Canada write in the Journal of Biological Chemistry about pinpointing a toxin injected by one soil-dwelling bacterium into another that protects plants from disease.
From the journals: September 2018
Journal News

From the journals: September 2018

9/1/2018
What’s the link between lipids and sleep apnea? How is obesity related to fertility? What’s the fastest way to screen heart drugs? Read about these topics and more in our roundup of recent papers from the Journal of Biological Chemistry, the Journa…
JBC: In reading histone modifications, an oncoprotein is modified in return
Journal News

JBC: In reading histone modifications, an oncoprotein is modified in return

9/1/2018
Researchers in Texas report in the Journal of Biological Chemistry that they’ve uncovered an unusual form of protein cross talk, suggesting new ways of inhibiting cancer metastasis.
From the journals: August 2018
Journal News

From the journals: August 2018

8/1/2018
Why are people with chronic kidney disease at high risk of heart failure? Can a pathogen avoid a host antibody by grabbing it? Why do some cancer cells love sugar and eschew fiber? Read about these topics and more in our roundup.
JBC: A shadowy organizational hub in cells
Journal News

JBC: A shadowy organizational hub in cells

8/1/2018
Researchers at Vanderbilt University report in the Journal of Biological Chemistry on their finding that this large enigmatic protein appears to form a bridge and recruit proteins involved in building microtubules in human cells.
JBC: A spring-loaded sensor for cholesterol in cells
Journal News

JBC: A spring-loaded sensor for cholesterol in cells

8/1/2018
Research from the University of New South Wales explains how an enzyme that helps the body make cholesterol acts as a thermostat that responds to and adjusts levels of cholesterol in the cell.
JBC: A phospholipid pathway from plants to parasites
Journal News

JBC: A phospholipid pathway from plants to parasites

6/1/2018
A study published in the Journal of Biological Chemistry looks at how inhibitors of an enzyme that produces a form of choline might be used to treat parasitic diseases, including malaria.
JBC: A sugar-attaching enzyme defines colon cancer
Journal News

JBC: A sugar-attaching enzyme defines colon cancer

6/1/2018
An enzyme that is not found in healthy colons appears to drive the conversion of colon tissue into cancer by attaching sugar molecules to certain proteins in the cell, researchers write in the Journal of Biological Chemistry.
From the journals: June/July 2018
Journal News

From the journals: June/July 2018

6/1/2018
What can proteomics teach us about dying cancer cells? Why do some bacteria survive contact with copper? What happens when brown fat cells turn white? Read about these topics and more.
From the journals: May 2018
Journal News

From the journals: May 2018

5/1/2018
Is there a way to kill fat cells to make weight loss last?  What’s the significance of cholesterol efflux capacity levels in octogenarians?  Read about these topics and more in our roundup of recent papers from the Journal of Biological Chemistry, t…
JBC: Antibiotic resistance in pandemic cholera
Journal News

JBC: Antibiotic resistance in pandemic cholera

5/1/2018
A research team at the University of Georgia reports in the Journal of Biological Chemistry on the unique role of a protein that allows cholera bacteria to resist antimicrobial peptides that are synthesized for use as last-line drugs.
JBC: Simulations might speed drug target discovery
Journal News

JBC: Simulations might speed drug target discovery

5/1/2018
Researchers at Caltech tackle the problem of producing sufficient membrane proteins in the lab for drug experiments by focusing on how efficiently a cell inserts a newly synthesized protein into the membrane.
From the journals: April 2018
Journal News

From the journals: April 2018

4/1/2018
Which fats make a healthier mouse? How can you ensure sperm have both heads and tails? Read about these topics and more in our roundup of recent papers from ASBMB journals.
Metal art, microbial culture
Art

Metal art, microbial culture

4/1/2018
Sasha Mushegian writes about researchers in Switzerland who are looking to bacteria and fungi to preserve everything from a modern bronze sculpture to a 17th-century wooden warship.
JBC: How an interest in bipolar disorder drugs led to a better understanding of leukemia
Journal News

JBC: How an interest in bipolar disorder drugs led to a better understanding of leukemia

4/1/2018
While investigating how lithium inhibits the enzyme GSK-3, researchers discovered that GSK-3 could affect RNA splicing — and aberrant splicing causes white blood cell proliferation in leukemia.
JBC: A molecular garbage disposal has a role in packing the genome
Journal News

JBC: A molecular garbage disposal has a role in packing the genome

4/1/2018
Using yeast cells, researchers found that the proteasome, which breaks down proteins, also can both induce and stop the spread of heterochromatin in the genome.
From the journals: March 2018
Journal News

From the journals: March 2018

3/1/2018
Eczema lotion inspired by babies’ skin. Steps toward accessible vaccines. How staph bacteria steals iron. Read about these topics and more.
JBC: When HIV drugs don’t cooperate
Journal News

JBC: When HIV drugs don’t cooperate

3/1/2018
A pair of second-line HIV drugs are expected to boost each other, but researchers write in the Journal of Biological Chemistry that co-receptor antagonists and fusion inhibitors don’t synergize as expected when certain viral proteins evolve to avoid…
JBC: A rare blood disease can teach us about clotting
Journal News

JBC: A rare blood disease can teach us about clotting

3/1/2018
A paper in the Journal of Biological Chemistry describes how mutations in antithrombin proteins occur in unexpected places, which could cause researchers to reconsider the best way to prevent obstructive blood clots.
JBC: Sugary secrets of a cancer-related protein
Journal News

JBC: Sugary secrets of a cancer-related protein

2/1/2018
A rare type of glycosylation profoundly affects the function of Notch, a protein that is important for human development and cancer progression.
JBC: Scientists find cellular backup plan for keeping iron levels just right
Journal News

JBC: Scientists find cellular backup plan for keeping iron levels just right

2/1/2018
Researchers have uncovered a connection in the network of checks and balances underlying cellular iron regulation.
From the journals: February 2018
Journal News

From the journals: February 2018

2/1/2018
How amino acids determine cells’ responses climate change. How genes cause bile acid diarrhea. And how trypsin trips up researchers studying alternative splicing. Read about these topics and more in our roundup of recent papers from the Journal of B…
JBC: Expanding the reach of therapeutic antibodies
Journal News

JBC: Expanding the reach of therapeutic antibodies

1/1/2018
Researchers describe a new approach to efficiently produce antibodies that can bind to two different target molecules simultaneously, a long-desired innovation in cancer immunotherapy.
From the journals: January 2018
Journal News

From the journals: January 2018

1/1/2018
Alcohol plus hepatitis B raises cholesterol. A chemical cocktail reprograms mouse cells. Prion protein does more than wreak havoc. Read about these topics and more in our roundup of recent papers from the Journal of Biological Chemistry, the Journa…
JBC: What makes organelles connect?
Journal News

JBC: What makes organelles connect?

12/1/2017
A Journal of Biological Chemistry paper describes how new technology helps researchers identify the proteins that allow the mitochondria and the endoplasmic reticulum to attach to each other.