Proteins and proteomics
Glaucoma model links immune signaling to disease progression
Researchers at Duke University determine genetic variations that could increase the risk of developing glaucoma.
Uncovering the molecular roots of fatty liver disease
Physician–scientist Silvia Sookoian discusses her path from hepatitis C care to MASLD research, her use of multi-omics to study steatotic liver disease, and how lipid metabolism and genetics are reshaping understanding of MASH and liver health.
Mitochondria shape kidney cell function
Researchers at the University of Washington, Seattle present the first quantitative comparison of mitochondrial interactomes between two epithelial cell types in the kidney.
Glycosylation patterns across antibody isotypes distinguish tuberculosis states
Researchers at Taipei Medical University present the first site-specific glycosylation analysis of immunoglobulins in elderly tuberculosis patients.
Blood glycome possibly predicts lifespan
Researchers at the University of Santiago de Compostela show that total serum N-glycome can predict mortality independent of traditional risk factors.
Building a better model for drug delivery across the blood–brain barrier
Industry and academic scientists collaborated to develop a rat with humanized iron-transport receptors, enabling research into iron homeostasis and drugs that cross the brain’s barrier.
Fat synthesis enzyme crucial for milk fat and newborn growth
Researchers found that a deficiency of the fatty acid synthesis enzyme stearoyl-CoA desaturase-1 reduced mammary gland function during lactation and caused low birth weight in newborns that were fed milk from enzyme-deficient glands.
Flipping lipids and slime molds
A dull first job nearly pushed JBC associate editor Todd Graham out of science. Then a slime mold project changed his path. Now, he studies membrane biology and reflects on discovery, persistence and mentoring through uncertainty.
The molecular orchestra of memory
Calcium, calmodulin and calcium/calmodulin-dependent kinase II form a molecular axis that turns fleeting neural activity into lasting memories. New research shows how memories are stabilized, and possibly even protected or repaired.