Metabolism
Building better tools to decipher the lipidome
Chemical engineer–turned–biophysicist Matthew Mitsche uses curiosity, coding and creativity to tackle lipid biology, uncovering PNPLA3’s role in fatty liver disease and advancing mass spectrometry tools for studying complex lipid systems.
Fasting, fat and the molecular switches that keep us alive
Nutritional biochemist and JLR AE Sander Kersten has spent decades uncovering how the body adapts to fasting. His discoveries on lipid metabolism and gene regulation reveal how our ancient survival mechanisms may hold keys to modern metabolic health.
Exploring the link between lipids and longevity
Meng Wang will present her work on metabolism and aging at the ASBMB Annual Meeting, March 7-10, just outside of Washington, D.C.
Defining a ‘crucial gatekeeper’ of lipid metabolism
George Carman receives the Herbert Tabor Research Award at the ASBMB Annual Meeting, March 7–10, just outside of Washington, D.C.
The science of staying strong
Muscles power every movement, but they also tell the story of aging itself. Scientists are uncovering how strength fades, why some species resist it and what lifestyle and molecular clues could help preserve muscle health for life.
Gut microbes hijack cancer pathway in high-fat diets
Researchers at the Feinstein Institutes for Medical Research found that a high-fat diet increases ammonia-producing bacteria in the gut microbiome of mice, which in turn disrupts TGF-β signaling and promotes colorectal cancer.
Cholesterol as a novel biomarker for Fragile X syndrome
Researchers in Quebec identified lower levels of a brain cholesterol metabolite, 24-hydroxycholesterol, in patients with fragile X syndrome, a finding that could provide a simple blood-based biomarker for understanding and managing the condition.
How lipid metabolism shapes sperm development
Researchers at Hokkaido University identify the enzyme behind a key lipid in sperm development. The findings reveal how seminolipids shape sperm formation and may inform future diagnostics and treatments for male infertility.
Proteomics reveals protein shifts in diabetic eye disease
Using proteomics, researchers identified protein changes in eye fluid that mark diabetic retinopathy progression and may serve as biomarkers for vision-threatening complications. Read more about this recent MCP paper.