Metabolism

Lipid-lowering therapies could help treat IBD

Genetic evidence shows that drugs that reduce cholesterol or triglyceride levels can either raise or lower inflammatory bowel disease risk by altering gut microbes and immune signaling.

Missing lipid shrinks heart and lowers exercise capacity

Researchers uncovered the essential role of PLAAT1 in maintaining heart cardiolipin, mitochondrial function and energy metabolism, linking this enzyme to exercise capacity and potential cardiovascular disease pathways.

Decoding how bacteria flip host’s molecular switches

Kim Orth will receive the Earl and Thressa Stadtman Distinguished Scientists Award at the ASBMB Annual Meeting, March 7–10, just outside of Washington, D.C.

Building better tools to decipher the lipidome

Chemical engineer–turned–biophysicist Matthew Mitsche uses curiosity, coding and creativity to tackle lipid biology, uncovering PNPLA3’s role in fatty liver disease and advancing mass spectrometry tools for studying complex lipid systems.

Fasting, fat and the molecular switches that keep us alive

Nutritional biochemist and JLR AE Sander Kersten has spent decades uncovering how the body adapts to fasting. His discoveries on lipid metabolism and gene regulation reveal how our ancient survival mechanisms may hold keys to modern metabolic health.

Exploring the link between lipids and longevity

Meng Wang will present her work on metabolism and aging at the ASBMB Annual Meeting, March 7-10, just outside of Washington, D.C.

Defining a ‘crucial gatekeeper’ of lipid metabolism

George Carman receives the Herbert Tabor Research Award at the ASBMB Annual Meeting, March 7–10, just outside of Washington, D.C.

The science of staying strong

Muscles power every movement, but they also tell the story of aging itself. Scientists are uncovering how strength fades, why some species resist it and what lifestyle and molecular clues could help preserve muscle health for life.

Gut microbes hijack cancer pathway in high-fat diets

Researchers at the Feinstein Institutes for Medical Research found that a high-fat diet increases ammonia-producing bacteria in the gut microbiome of mice, which in turn disrupts TGF-β signaling and promotes colorectal cancer.