Cancer

Scientists track 'doubling' in origin of cancer cells

Researchers at Johns Hopkins say they have charted a molecular pathway that can lure cells down a hazardous path of duplicating their genome too many times.

'Protein sandwich' could transform cancer drug discovery

A team led by Alessio Ciulli has defined a new class of so-called “intramolecular bivalent glue,” which binds proteins that would otherwise stay apart.

Focusing on a pivotal axis in chemoresistance

Answers may lie in microRNA changes at the intersection of a cell cycle–regulating protein and a transcription factor that plays various roles in cancer.

A focus on histone modifications in development and disease

Three researchers will present the Soshev group’s work at Discover BMB.

Researchers get to the bottom of noninvasive gut tests

Mucus contains vital data to help address diseases such as inflammatory bowel disease and colon cancer.

AI harnesses tumor genetics to predict treatment response

Many paths lead to cancer resistance; artificial intelligence can decode them all simultaneously.

Immune cells become exhausted within hours of encountering tumors

New research might explain why many immunotherapy patients don’t see long-term remission.

Exploring glycosylation patterns in oral cancer

Mass spectrometry–based glycomics and glycoproteomics help identify and characterize proteins in tumor tissues, offering insights into patient prognosis.

Improvements in genome databases promising for cancer research

Scientists expand the use of ribosome profiling, also known as Ribo-seq, to understand protein production in cells.