Computational and structural biology
New class of antimicrobials discovered in soil bacteria
Scientists have mined Streptomyces for antibiotics for nearly a century, but the newly identified umbrella toxin escaped notice.
Hinton lab maps structure of mitochondria at different life stages
An international team determines the differences in the 3D morphology of mitochondria and cristae, their inner membrane folds, in brown adipose tissue.
AI harnesses tumor genetics to predict treatment response
Many paths lead to cancer resistance; artificial intelligence can decode them all simultaneously.
AI generates proteins with exceptional binding strength
The advance could allow scientists to develop cheaper alternatives to antibodies for disease detection and treatment.
Molecular origins of function revealed for a key drug target
Scientists show how G protein-coupled receptors decode critical properties of their ligands.
Receptor regulation clues may scratch an itch
Thomas Sakmar’s lab found that a GPCR associated with a liver disease symptom is regulated in previously unknown ways, possibly leading to new therapies.
How DNA structure controls CRISPR
Montana State scientists publish research on CRISPR DNA bending.
Building the first cryo-EM facility in South Texas
In 2022, Lijia Jia assembled a $3 million microscope with a field engineer from Thermo Fisher and set up its computing infrastructure.
JBC editors weigh in on AI in science publishing
In an editorial, they say they’ll allow its use in manuscript preparation but not during the review process.