Computational and structural biology

Mining microbes for rare earth solutions

Joseph Cotruvo, Jr., will receive the ASBMB Mildred Cohn Young Investigator Award at the ASBMB Annual Meeting, March 7–10, just outside of Washington, D.C.

Mapping proteins, one side chain at a time

Roland Dunbrack Jr. will receive the ASBMB DeLano Award for Computational Biosciences at the ASBMB Annual Meeting, March 7–10, just outside of Washington, D.C.

Building the blueprint to block HIV

Wesley Sundquist will present his work on the HIV capsid and revolutionary drug, Lenacapavir, at the ASBMB Annual Meeting, March 7–10, in Maryland.

Designing life’s building blocks with AI

Tanja Kortemme, a professor at the University of California, San Francisco, will discuss her research using computational biology to engineer proteins at the 2026 ASBMB Annual Meeting.

Mass spec method captures proteins in native membranes

Yale scientists developed a mass spec protocol that keeps proteins in their native environment, detects intact protein complexes and tracks drug binding, offering a clearer view of membrane biology.

Laser-assisted cryoEM method preserves protein structure

University of Wisconsin–Madison researchers devised a method that prevents protein compaction during cryoEM prep, restoring natural structure for mass spec studies. The approach could expand high-resolution imaging to more complex protein systems.

Method sharpens proteome-wide view of structural changes

Researchers developed a method that improves limited proteolysis coupled with mass spectrometry, separating true changes from abundance or splicing effects.

New chemical strategy boosts accuracy in proteomics

Researchers develop a methylamine-based method that nearly eliminates peptide overlabeling in proteomics, improving accuracy in protein identification and quantitation.

Spider-like proteins spin defenses to control immunity

Researchers from Utrecht University discovered two distinct binding modes of a spider-shaped immune inhibitor found in serum.