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Training AI to uncover novel antimicrobials

News and Ideas

AI-designed biomarker improves malaria diagnostics
Researchers from the University of Melbourne engineered Plasmodium vivax diagnostic protein with enhanced yield and stability while preserving antibody-binding, paving the way for more reliable malaria testing.

Matrix metalloproteinase inhibitor reduces cancer invasion
Scientists at the Mayo Clinic engineered a TIMP-1 protein variant that selectively inhibits MMP-9 and reduces invasion of triple-negative breast cancer cells, offering a promising tool for targeted cancer research.

Antibiotic sensor directly binds drug in resistant bacteria
Researchers at Drexel University uncover how the vancomycin-resistant bacterial sensor binds to the antibiotic, offering insights to guide inhibitor design that restores antibiotic effectiveness against hospital-acquired infections.

Bioart for fall: From order to disorder
The cover of the fall issue of ASBMB Today was created by ASBMB member, Soutick Saha, a bioinformatics developer at Wolfram Alpha LLC.

Doudna wins Priestley Medal
She will receive a $20,000 research grant and will formally accept the honor at the ACS Spring 2026 conference.

Upcoming opportunities
The Lipid Research Division Seminar Series returns Oct. 15 with talks on recent advances in triglyceride cycling in adipocytes.

Writing with AI turns chaos into clarity
Associate professor shares how generative AI, used as a creative whiteboard, helps scientists refine ideas, structure complexity and sharpen clarity — transforming the messy process of discovery into compelling science writing.

ApoA1 reduce atherosclerotic plaques via cell death pathway
Researchers show that ApoA1, a key HDL protein, helps reduce plaque and necrotic core formation in atherosclerosis by modulating Bim-driven macrophage death. The findings reveal new insights into how ApoA1 protects against heart disease.

Omega-3 lowers inflammation, blood pressure in obese adults
A randomized study shows omega-3 supplements reduce proinflammatory chemokines and lower blood pressure in obese adults, furthering the understanding of how to modulate cardiovascular disease risk.
Meet Our Contributors

Courtney Chandler

Jessica Desamero

Jay Thakkar

Poornima Sankar
Who decides when a grad student graduates?
Courtney Chandler
Careers Columnist
Ph.D. programs often don’t have a set timeline. Students continue with their research until their thesis is done, which is where variability comes into play. Read More
Beyond the bench: On a mission to build an inclusive scientific community
Benjamin Garcia will receive the ASBMB Ruth Kirschstein Diversity in Science Award at the ASBMB Annual meeting, April 12–15 in Chicago. Read More
Computational biosciences illuminate how molecular condensates form
Rohit Pappu will receive the 2025 DeLano Award for Computational Biosciences at the ASBMB Annual Meeting, April 12-15 in Chicago. Read More
Quantifying how proteins in microbe and host interact
“To develop better vaccines, we need new methods and a better understanding of the antibody responses that develop in immune individuals,” author Johan Malmström said. Read More
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