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Blood glycome possibly predicts lifespan
Researchers at the University of Santiago de Compostela show that total serum N-glycome can predict mortality independent of traditional risk factors.
Building a better model for drug delivery across the blood–brain barrier
Industry and academic scientists collaborated to develop a rat with humanized iron-transport receptors, enabling research into iron homeostasis and drugs that cross the brain’s barrier.
Fat synthesis enzyme crucial for milk fat and newborn growth
Researchers found that a deficiency of the fatty acid synthesis enzyme stearoyl-CoA desaturase-1 reduced mammary gland function during lactation and caused low birth weight in newborns that were fed milk from enzyme-deficient glands.
Flipping lipids and slime molds
A dull first job nearly pushed JBC associate editor Todd Graham out of science. Then a slime mold project changed his path. Now, he studies membrane biology and reflects on discovery, persistence and mentoring through uncertainty.
How smelling death alters worm behavior
Researchers have found that the roundworm C. elegans can smell death, and it changes how the worms behave, reproduce and age.
A chance encounter with the lab
Payton Stevens never planned to become a pancreatic cancer researcher. A temporary job set him on a path from rural Kentucky to leading research on Wnt signaling and metastasis, where he now pairs discovery with mentorship and science advocacy.
Light-activated small molecule could transform eye infection treatment
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The molecular orchestra of memory
Calcium, calmodulin and calcium/calmodulin-dependent kinase II form a molecular axis that turns fleeting neural activity into lasting memories. New research shows how memories are stabilized, and possibly even protected or repaired.
Differences in pili structure modulate bacterial behavior
Researchers demonstrate how small changes in the structure of hair-like protein appendages can affect the behavior of Acinetobacter bacteria.
Cholesterol regulatory genes predict liver transplant outcomes
Researchers identify a link between cholesterol-regulating genes and liver transplant success, which could improve donor screening and patient outcomes.
Lipid signatures for a rare neurological disorder
Researchers find distinct lipid patterns linked to a rare autoimmune neurological disorder, offering hope for effective targeted therapies for patients.
Disease-linked mutations disrupt protein phase behavior
Researchers find that pathogenic missense mutations are enriched threefold in phrase-separating intrinsically disordered regions of proteins.
The dual role of asprosin in chronic fatty liver disease
Researchers uncover a hormone called asprosin that may serve as a potential biomarker for the diagnosis of chronic fatty liver disease and monitoring disease progression.
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