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Folic Acid Awareness Week
The National Birth Defects Prevention Network and related organizations observed Folic Acid Awareness Week this week to educate the public, in particular mothers-to-be, about the role that folic acid plays in preventing congenital disabilities.
How to catch an HIF
The 1995 discovery of hypoxia-inducible factor by the lab of Gregg Semenza was a major milestone in figuring out how cells sense oxygen.
Holidays may break our resolve, but not our microbiomes
The connection between what we eat and which bacteria wind up dominating our gut is well established, but a few weeks of eating nonhabitual foods are unlikely to alter the composition of your gut bacteria significantly.
Flipping lipids to deform membranes
The plasma membrane changes shape during cell migration, cancer cell invasion, cell division, nutrient uptake and entry of pathogens into cells. Lipid-flipping activity may be involved in any or all of these processes.
From the journals: JBC
Articles in the Journal of Biological Chemistry investigate immune receptor binding; barrel-shaped organelles called vaults; de novo dNTP synthesis; and a specific SNARE inhibitor.
From the journals: MCP
Articles in the journal Molecular & Cellular Proteomics report peptide signatures for ID'g bacteria. the first evidence of phosphorylation in Francisella tularensis, how pathogenic phleboviruses bud and exit host cells, and more.
A new hotspot for cyclooxygenase inhibition
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Crystal building blocks of triglycerides
Using methods that include crystallography and cryo-electron microscopy, recent work in three labs has defined structures and mechanisms in triglycerides, Michael Airola writes.
Rounding out the year with nickel and zinc
Quira Zeidan ends her yearlong series marking the 150th anniversary of Dmitri Mendeleev’s periodic table with a look at the two metallic elements with chemical symbols Ni and Zn.
JBC: Tor comes to the fore in autophagy
Yoshinori Ohsumi, Takeshi Noda and colleagues at the National Institute for Basic Biology in Japan discovered that the Tor protein controls the breakdown process of autophagy in yeast cells. Martin Spiering writes about their classic paper.
JBC: Paving the way for disease-resistant rice
Scientists have found that a rice immune receptor triggers reactions in response to fungal proteins, a first step toward using gene editing to prevent the crop destruction caused by rice blast disease.
JLR: Secrets of fat and the lymph node
Some 20 years ago, Sander Kersten isolated a protein that acts as a control for how our bodies store or burn fat. Recently, he wrote in the Journal of Lipid Research about why loss of this protein can be fatal to mice.
MCP: When prions are personal
In a quest to cure the deadly protein folding disease that runs in his wife’s family, a researcher publishes a new assay for monitoring protein levels in the journal Molecular & Cellular Proteomics.
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