Science
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We are family: Tracing the evolution of animals
To understand the origins of muticelled life, researchers are studying a motley assortment of simpler animal relatives. The commonalities they’re unearthing offer a trove of clues about our mutual past.
3D shapes of viral proteins point to previously unknown roles
A research team led by Jennifer Doudna has harnessed computational and deep-learning tools to predict the shapes of nearly 4,500 species that infect animals and humans.
From the journals: MCP
Microglia EVs as biomarkers for neuronal diseases. Automated workflow for single-cell proteomics. Circadian rhythmic protein analysis in tissues. Read about these recent MCP papers.
Bridging the gap – enhancing and unifying bone RNA-seq data
Researchers aimed to increase the number of osteoblasts and osteocytes collected and combine their data with other studies to help standardize nomenclature.
What I’ve learned about water, aging and protein quality control
Alice Liu thought an increase in heat shock protein chaperones would prevent misfolding in Huntington’s disease proteins. The results surprised her, and water was the key.
Helping mitochondria run smoothly may protect against Parkinson’s disease
As the powerhouse of the cell, mitochondria lie at the intersection of many essential biochemical pathways. When they go awry, neurodegenerative diseases can result.
Bacteria encode hidden genes outside their genome — do we?
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Nobel for ‘breakthrough in biochemistry’
David Baker, Demis Hassabis and John M. Jumper received the chemistry prize for computational protein design and structure prediction.
Nobel honors discovery of microRNAs
Ambros and Ruvkun win prize for medicine or physiology “for the discovery of microRNA and its role in post-transcriptional gene regulation.”
Keeping skin healthy: New method provides molecular portrait of sebum production
In a recent JBC paper, researchers at Leipzig University report that they have spatially mapped changes in gene expression in sebaceous glands for the first time.
From the journals: JLR
Restricting chromatin access improves liver health. Ion channels and tumor aggressiveness. Sphingolipid mutations drive cognitive impairments. Read about recent articles on these topics.
The molecular biology behind exercise
Researchers in Beijing use proteomic analysis to understand the muscular adaptations made during concentric and eccentric movements.
A common parasite could one day deliver drugs to the brain
Bill Sullivan explains how scientists are turning Toxoplasma gondii, often found in contaminated food or cat feces, from foe into friend.
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