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From the JBC archives: Madness, indoles and mercury-based cathartics
A 1907 paper sought to resolve an ongoing question of whether indole, a bacterial molecule in the gut, could cause insanity if overproduced.

From the journals: JBC
Linking modified cysteines to cell migration. Recognizing protein tags for degradation. Disrupting C. difficile toxin production. Read about recent JBC papers on these topics.

Becoming a scientific honey bee
At the World Science Forum, a speaker’s call for scientists to go out and “make honey” felt like the answer to a question Katy Brewer had been considering for a long time.

Mutant RNA exosome protein linked to neurodevelopmental defects
Researchers at Emory University find that a missense mutation impairs RNA exosome assembly and translation and causes neurological disease.

Study sheds light on treatment for rare genetic disorder
Aaron Hoskins’ lab partnered with a drug company to understand how RNA-targeting drugs work on spinal muscular atrophy, a disorder resulting from errors in production of a protein related to muscle movement.

Examining mechanisms of protein complex at a basic cell biological level
Mary Munson is co-corresponding author on a study revealing functions and mechanisms of the exocyst that are essential to how molecules move across a membrane through vesicles in a cell.
Breaking through limits in kinase inhibition

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How opposing metabolic pathways regulate inflammation
Researchers use cybernetics to understand what happens when two acids produced by macrophages compete for binding sites on the enzyme that converts them to active products.

We are all mosaics
Your body is a collection of cells carrying thousands of genetic mistakes accrued over a lifetime — many harmless, some bad, and at least a few that may be good for you.

From the journals: MCP
Finding biomarkers for preeclampsia. Early diagnostic biomarkers of pancreatic cancer. Better tools to identify tumor-specific peptides. Read about these recent MCP papers.

RNA binding proteins with benefits
Blanton Tolbert studies the biochemical mechanisms of RNA virus replication while working to make science more accessible, and more interesting, for all people.

A proteomic hunt for phosphosites in the aging brain
In older mice, researchers found more enzymes that phosphorylate other proteins and changes in phosphorylation levels in proteins associated with neurodegeneration.

What if a virus could reverse antibiotic resistance?
In promising experiments, phage therapy forces bacteria into a no-win dilemma that lowers their defenses against drugs they’d evolved to withstand.
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