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Uncovering the molecular roots of fatty liver disease
Physician–scientist Silvia Sookoian discusses her path from hepatitis C care to MASLD research, her use of multi-omics to study steatotic liver disease, and how lipid metabolism and genetics are reshaping understanding of MASH and liver health.
Mitochondria shape kidney cell function
Researchers at the University of Washington, Seattle present the first quantitative comparison of mitochondrial interactomes between two epithelial cell types in the kidney.
Long-chain polyunsaturated fatty acids linked to postoperative delirium risk
Researchers show that altered lipid metabolism may contribute to postoperative delirium, a condition linked to increased risk for long-term cognitive decline. The study explores potential disease mechanisms, which have yet to be understood.
Glycosylation patterns across antibody isotypes distinguish tuberculosis states
Researchers at Taipei Medical University present the first site-specific glycosylation analysis of immunoglobulins in elderly tuberculosis patients.
Blood glycome possibly predicts lifespan
Researchers at the University of Santiago de Compostela show that total serum N-glycome can predict mortality independent of traditional risk factors.
Building a better model for drug delivery across the blood–brain barrier
Industry and academic scientists collaborated to develop a rat with humanized iron-transport receptors, enabling research into iron homeostasis and drugs that cross the brain’s barrier.
Fat synthesis enzyme crucial for milk fat and newborn growth
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Flipping lipids and slime molds
A dull first job nearly pushed JBC associate editor Todd Graham out of science. Then a slime mold project changed his path. Now, he studies membrane biology and reflects on discovery, persistence and mentoring through uncertainty.
How smelling death alters worm behavior
Researchers have found that the roundworm C. elegans can smell death, and it changes how the worms behave, reproduce and age.
A chance encounter with the lab
Payton Stevens never planned to become a pancreatic cancer researcher. A temporary job set him on a path from rural Kentucky to leading research on Wnt signaling and metastasis, where he now pairs discovery with mentorship and science advocacy.
Light-activated small molecule could transform eye infection treatment
Contact lenses raise the risk of infectious keratitis, a leading cause of blindness worldwide. A biotech company is commercializing a light-activated therapy using a ROS-generating molecule to rapidly kill microbes in the cornea to preserve vision.
The molecular orchestra of memory
Calcium, calmodulin and calcium/calmodulin-dependent kinase II form a molecular axis that turns fleeting neural activity into lasting memories. New research shows how memories are stabilized, and possibly even protected or repaired.
Differences in pili structure modulate bacterial behavior
Researchers demonstrate how small changes in the structure of hair-like protein appendages can affect the behavior of Acinetobacter bacteria.
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