Neurobiology
Glaucoma model links immune signaling to disease progression
Researchers at Duke University determine genetic variations that could increase the risk of developing glaucoma.
Long-chain polyunsaturated fatty acids linked to postoperative delirium risk
Researchers show that altered lipid metabolism may contribute to postoperative delirium, a condition linked to increased risk for long-term cognitive decline. The study explores potential disease mechanisms, which have yet to be understood.
Building a better model for drug delivery across the blood–brain barrier
Industry and academic scientists collaborated to develop a rat with humanized iron-transport receptors, enabling research into iron homeostasis and drugs that cross the brain’s barrier.
How smelling death alters worm behavior
Researchers have found that the roundworm C. elegans can smell death, and it changes how the worms behave, reproduce and age.
Light-activated small molecule could transform eye infection treatment
Contact lenses raise the risk of infectious keratitis, a leading cause of blindness worldwide. A biotech company is commercializing a light-activated therapy using a ROS-generating molecule to rapidly kill microbes in the cornea to preserve vision.
The molecular orchestra of memory
Calcium, calmodulin and calcium/calmodulin-dependent kinase II form a molecular axis that turns fleeting neural activity into lasting memories. New research shows how memories are stabilized, and possibly even protected or repaired.
Lipid signatures for a rare neurological disorder
Researchers find distinct lipid patterns linked to a rare autoimmune neurological disorder, offering hope for effective targeted therapies for patients.
Catching tau in the act
Using a new proximity-labeling approach, researchers reveal how tangles of the brain-associated protein tau may disrupt RNA biology long before neurons die.
Uncovering the mechanisms of a glycosylation disorder
Mutations in OGT, an enzyme that adds sugars to proteins, cause a rare neurological disorder. Using proteomics, researchers reveal how OGT interactions with TET proteins may trigger epigenetic changes and early neural defects.