Cell biology
Glaucoma model links immune signaling to disease progression
Researchers at Duke University determine genetic variations that could increase the risk of developing glaucoma.
Uncovering the molecular roots of fatty liver disease
Physician–scientist Silvia Sookoian discusses her path from hepatitis C care to MASLD research, her use of multi-omics to study steatotic liver disease, and how lipid metabolism and genetics are reshaping understanding of MASH and liver health.
Mitochondria shape kidney cell function
Researchers at the University of Washington, Seattle present the first quantitative comparison of mitochondrial interactomes between two epithelial cell types in the kidney.
Building a better model for drug delivery across the blood–brain barrier
Industry and academic scientists collaborated to develop a rat with humanized iron-transport receptors, enabling research into iron homeostasis and drugs that cross the brain’s barrier.
Fat synthesis enzyme crucial for milk fat and newborn growth
Researchers found that a deficiency of the fatty acid synthesis enzyme stearoyl-CoA desaturase-1 reduced mammary gland function during lactation and caused low birth weight in newborns that were fed milk from enzyme-deficient glands.
How smelling death alters worm behavior
Researchers have found that the roundworm C. elegans can smell death, and it changes how the worms behave, reproduce and age.
Light-activated small molecule could transform eye infection treatment
Contact lenses raise the risk of infectious keratitis, a leading cause of blindness worldwide. A biotech company is commercializing a light-activated therapy using a ROS-generating molecule to rapidly kill microbes in the cornea to preserve vision.
The molecular orchestra of memory
Calcium, calmodulin and calcium/calmodulin-dependent kinase II form a molecular axis that turns fleeting neural activity into lasting memories. New research shows how memories are stabilized, and possibly even protected or repaired.
Differences in pili structure modulate bacterial behavior
Researchers demonstrate how small changes in the structure of hair-like protein appendages can affect the behavior of Acinetobacter bacteria.