Cell biology
The data that did not fit
Brent Stockwell’s perseverance and work on the small molecule erastin led to the identification of ferroptosis, a regulated form of cell death with implications for cancer, neurodegeneration and infection.
Ragweed compound thwarts aggressive bladder and breast cancers
Scientists from the University of Michigan reveal the mechanism of action of ambrosin, a compound from ragweed, selectively attacks advanced bladder and breast cancer cells in cell-based models, highlighting its potential to treat advanced tumors.
Key regulator of cholesterol protects against Alzheimer’s disease
A new study identifies oxysterol-binding protein-related protein 6 as a central controller of brain cholesterol balance, with protective effects against Alzheimer’s-related neurodegeneration.
From humble beginnings to unlocking lysosomal secrets
Monther Abu–Remaileh will receive the ASBMB’s 2026 Walter A. Shaw Young Investigator Award in Lipid Research at the ASBMB Annual Meeting, March 7-10 in Washington, D.C.
Missing lipid shrinks heart and lowers exercise capacity
Researchers uncovered the essential role of PLAAT1 in maintaining heart cardiolipin, mitochondrial function and energy metabolism, linking this enzyme to exercise capacity and potential cardiovascular disease pathways.
Decoding how bacteria flip host’s molecular switches
Kim Orth will receive the Earl and Thressa Stadtman Distinguished Scientists Award at the ASBMB Annual Meeting, March 7–10, just outside of Washington, D.C.
Defining JNKs: Targets for drug discovery
Roger Davis will receive the Bert and Natalie Vallee Award in Biomedical Science at the ASBMB Annual Meeting, March 7–10, just outside of Washington, D.C.
Building better tools to decipher the lipidome
Chemical engineer–turned–biophysicist Matthew Mitsche uses curiosity, coding and creativity to tackle lipid biology, uncovering PNPLA3’s role in fatty liver disease and advancing mass spectrometry tools for studying complex lipid systems.
Redefining lipid biology from droplets to ferroptosis
James Olzmann will receive the ASBMB Avanti Award in Lipids at the ASBMB Annual Meeting, March 7–10, just outside of Washington, D.C.