Cell biology
Parsing plant pigment pathways
Erich Grotewold of Michigan State University, an ASBMB Breakthroughs speaker, discusses his work on the genetic regulation of flavonoid biosynthesis.
Calcium channel linked to cancer drug resistance
Researchers discover a protein associated with carboplatin-resistant retinoblastoma, suggesting this protein could be a promising therapeutic target. Read more about this recent Journal of Biological Chemistry paper.
Host fatty acids enhance dengue virus infectivity
Researchers in Germany find that viral replication depends on host enzymes that synthesize lipids, revealing potential metabolic targets for antiviral intervention. Read more about this recent Journal of Biological Chemistry paper.
Antibodies inhibit hyperactive protein disposal
Researchers at the University of California, San Francisco, identify an enzyme inhibitor, offering new tools to study diseases like cystic fibrosis, neurodegeneration and cancer. Read more about this recent Journal of Biological Chemistry paper.
Computational tool helps scientists create novel bug sprays
Rapid discovery of mosquito repellent compounds is enabled through a novel screening platform that combines both computational modeling and functional screening.
Influenza gets help from gum disease bacteria
Scientists discover that a protease from Porphyromonas gingivalis enhances viral spread. Read more about this recent Journal of Biological Chemistry paper.
How bacteria fight back against promising antimicrobial peptide
Researchers find a mutation in E. coli that reduces its susceptibility to a potential novel antibiotic. Read more about this recent Journal of Biological Chemistry paper.
New clues reveal how cells respond to stress
Redox signaling protein may help regulate inflammasome and innate immune activation. Read more about this recent Journal of Biological Chemistry paper.
Innovative platform empowers scientists to transform venoms into therapeutics
Scientists combine phage display and a “metavenome” library to discover new drugs that bind clinically relevant human cell receptors. Read about this recent Molecular & Cellular Proteomics paper.