Cells beat stress — so can you!
Organisms can’t avoid stress, so it is not surprising that numerous cellular mechanisms have evolved to temper any toxic effects of stress. Stress responses are triggered within every cellular compartment to activate downstream signaling pathways. Distinct stress responses can lead to production of protective molecular chaperones, alter post-translational modifications and protein trafficking, activate pathways that degrade macromolecules, and change cellular and organellar function and architecture. Together, these responses maintain organelle and cellular homeostasis and, more specifically, protein homeostasis, also known as proteostasis.
Studies in model systems have uncovered the circuits that control these varied responses, the components that mediate cellular protection, and how disruption or changes in the efficacy of these responses can be linked to specific diseases. Speakers will describe, at the molecular level, how cellular and organelle homeostasis is maintained under normal conditions and when cells and organisms encounter stress.
Keywords: protein quality control, organelles, stress responses, heat shock proteins, endoplasmic reticulum–associated degradation, autophagy, unfolded protein response
Who should attend: everyone interested in the diverse mechanisms by which cells cope with stress related to environmental or disease insults, including how different cellular compartments signal stress or respond to restore cellular homeostasis
Theme song: “Under pressure” by David Bowie and Queen
This session is powered by stressed-out cells and organelles.
Talks
- The degradation of misfolded proteins in the ER — Jeffrey Brodsky, University of Pittsburgh
- Post-translational control of HMG CoA reductase, the rate-limiting enzyme of cholesterol synthesis— Russell DeBose–Boyd, University of Texas Southwest Medical Center
- Signaling principles, signal decoding and integration revealed by stress — Diego Acosta-Alver, University of California, Santa Barbara
- The role of rhomboid pseudoproteases in ERADicating misfolded membrane substrates — Sonya Neal, University of California, San Diego
- Mechanisms of membrane protein sorting — Sichen (Susan) Shao, Harvard Medical School
- Peroxisomal quality control in Arabidopsis — Bonnie Bartel, Rice University
- Mitochondrial-derived compartments protect cells from nutrient stress — Adam Hughes, University of Utah
- Regulation of mitochondrial genome synthesis in animal cells — Samantha Lewis, University of California, Berkeley
- Mechanisms of stress granule regulation by ribosome-associated quality control factors — Stephanie Moon, University of Michigan
- Control of translation by ubiquitin during oxidative stress — Gustavo Silva, Duke University
- Proteins directing lipid fluxes at the ER–lipid droplet continuum — Elina Ikonen, University of Helsinki
- The interconnected dynamics of ribonucleoprotein condensates and the endoplasmic reticulum — Jason Lee, Baylor College of Medicine
Learn more
Check out all ten thematic symposia planned for the 2022 ASBMB annual meeting:
Enjoy reading ASBMB Today?
Become a member to receive the print edition monthly and the digital edition weekly.
Learn moreFeatured jobs
from the ASBMB career center
Get the latest from ASBMB Today
Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.
Latest in Science
Science highlights or most popular articles

FDA approves CRISPR–Cas9 therapy for sickle cell disease
The gene editing treatment from Vertex Pharmaceuticals and CRISPR Therapeutics is the first of its kind

From the journals: MCP
Metals contaminate protein samples. Lipid droplets go haywire in Huntington’s. Nerve cells respond to stimulation. Read about these recent papers.

The perfect storm
The world has 2023 Nobel laureates Katalin Karikó, Drew Weissman and others to thank for laying a foundation for the COVID-19 vaccine decades before the pandemic.

Throw your hat in the ring!
Apply to speak at Discover BMB in Chicago in 2025.

How bacteria inhibit gene expression
Researchers show how altering activity of the transcription factor CarD can cause downregulation and upregulation of some genes.

Where the heck did all those structures inside complex cells come from?
Scientists agree that eons ago, a bacterium took up residence inside another cell and became its powerhouse, the mitochondrion. But there are competing theories about the birth of other organelles such as the nucleus and endoplasmic reticulum.