Cells beat stress — so can you!
Organisms can’t avoid stress, so it is not surprising that numerous cellular mechanisms have evolved to temper any toxic effects of stress. Stress responses are triggered within every cellular compartment to activate downstream signaling pathways. Distinct stress responses can lead to production of protective molecular chaperones, alter post-translational modifications and protein trafficking, activate pathways that degrade macromolecules, and change cellular and organellar function and architecture. Together, these responses maintain organelle and cellular homeostasis and, more specifically, protein homeostasis, also known as proteostasis.
Studies in model systems have uncovered the circuits that control these varied responses, the components that mediate cellular protection, and how disruption or changes in the efficacy of these responses can be linked to specific diseases. Speakers will describe, at the molecular level, how cellular and organelle homeostasis is maintained under normal conditions and when cells and organisms encounter stress.
Keywords: protein quality control, organelles, stress responses, heat shock proteins, endoplasmic reticulum–associated degradation, autophagy, unfolded protein response
Who should attend: everyone interested in the diverse mechanisms by which cells cope with stress related to environmental or disease insults, including how different cellular compartments signal stress or respond to restore cellular homeostasis
Theme song: “Under pressure” by David Bowie and Queen
This session is powered by stressed-out cells and organelles.
Talks
- The degradation of misfolded proteins in the ER — Jeffrey Brodsky, University of Pittsburgh
- Post-translational control of HMG CoA reductase, the rate-limiting enzyme of cholesterol synthesis— Russell DeBose–Boyd, University of Texas Southwest Medical Center
- Signaling principles, signal decoding and integration revealed by stress — Diego Acosta-Alver, University of California, Santa Barbara
- The role of rhomboid pseudoproteases in ERADicating misfolded membrane substrates — Sonya Neal, University of California, San Diego
- Mechanisms of membrane protein sorting — Sichen (Susan) Shao, Harvard Medical School
- Peroxisomal quality control in Arabidopsis — Bonnie Bartel, Rice University
- Mitochondrial-derived compartments protect cells from nutrient stress — Adam Hughes, University of Utah
- Regulation of mitochondrial genome synthesis in animal cells — Samantha Lewis, University of California, Berkeley
- Mechanisms of stress granule regulation by ribosome-associated quality control factors — Stephanie Moon, University of Michigan
- Control of translation by ubiquitin during oxidative stress — Gustavo Silva, Duke University
- Proteins directing lipid fluxes at the ER–lipid droplet continuum — Elina Ikonen, University of Helsinki
- The interconnected dynamics of ribonucleoprotein condensates and the endoplasmic reticulum — Jason Lee, Baylor College of Medicine
Learn more
Check out all ten thematic symposia planned for the 2022 ASBMB annual meeting:
Enjoy reading ASBMB Today?
Become a member to receive the print edition four times a year and the digital edition weekly.
Learn moreFeatured jobs
from the ASBMB career center
Get the latest from ASBMB Today
Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.
Latest in Science
Science highlights or most popular articles
Does a protein hold the key to Alzheimer’s?
Researchers in Maryland and Massachusetts team up to study how SORL1 promotes tau trafficking and seeding in cells that leads to the neurodegenerative disorder.
Cracking the recipe for perfect plant-based eggs
It involves finding just the right proteins. With new ingredients and processes, the next generation of substitutes will be not just more egg-like, but potentially more nutritious.
MSU researchers leverage cryo-EM for decades-in-the-making breakthrough
Lee Kroos and Ben Orlando have reported the first high-resolution experimentally determined structures of the intramembrane protease SpolVFB.
From the Journals: MCP
Rapid and precise SARS-CoV-2 detection using mass spec. Mapping brain changes from drug addiction. Decoding plant osmotic stress response. Read about recent MCP papers on these topics.
What seems dead may not be dead
Vincent Tagliabracci will receive the Earl and Thressa Stadtman Distinguished Scientist Award at the ASBMB Annual Meeting, April 12–15 in Chicago.
'You can't afford to be 15 years behind the parasite'
David Fidock will receive the Alice and C.C. Wang Award in Molecular Parasitology at the 2025 ASBMB Annual Meeting, April 12–15 in Chicago.