Annual Meeting

MCSs stick the landing

Learn about the Discover BMB 2024 symposium on membrane contact sites
Christopher Beh Jen Liou
By Christopher Beh and Jen Liou
Sept. 15, 2023

Membrane contact sites, or MCSs, represent the ultimate intracellular duct tape — binding organelles together within eukaryotic cells to promote growth. Enabled by tethering proteins, MCSs are a coordinating nexus that fosters intermembrane exchange and signaling.

“The cell, too, has a geography, and its reactions occur in colloidal apparatus, of which the form, and the catalytic activity of its manifold surfaces, must efficiently contribute to the due guidance of chemical reactions.”  — Sir Frederick Gowland Hopkins (Nobel Prize in Physiology or Medicine, 1929)

As conduits for lipid and small metabolite transfer between organelle membranes, MCSs are key regulators of metabolism. As structural elements linking intracellular membranes, MCSs control membrane organization and protect against membrane stresses. As platforms for important signaling receptors, MCSs initiate cellular responses to regulatory or environmental cues.

The recognition of MCSs as key regulators of cell growth is underscored by new discoveries of MCS function in cellular disease and infection.

Keywords: Membrane contact sites, membrane stress, mitochondrial regulation, nonvesicular transport, lipid transport, membrane structure, lipid metabolism, lipid regulation.

Who should attend: Molecular cell biologists and membrane biochemists who marvel at how membrane dynamics regulates metabolic function and organelle organization.

Theme song: Dave Fenley cover of “Stuck on You” by Lionel Richie

This session is powered by the unsung heroes of membrane and lipid research.

Submit an abstract

Abstract submission begins Sept. 14. If you submit by Oct. 12, you'll get a decision by Nov. 1. The regular submission deadline is Nov. 30. See the categories.

Membrane contact sites

Regulation of lipid transfer and metabolism at membrane contact sites

 

Hongyuan YangUniversity of Texas Health Science Center at Houston

Jen Liou (chair), University of Texas Southwestern Medical Center

Alexandre ToulmayUniversity of Texas Southwestern Medical Center

Arash BashirullahUniversity of Wisconsin–Madison

Membrane signaling at membrane contact sites

Thomas Simmen (chair), University of Alberta

Jay TanUniversity of Pittsburgh

Alissa WeaverVanderbilt University

Chi-Lun ChangSt. Jude Children's Research Hospital

Specialized membrane contact site functions

Isabelle DerréUniversity of Virginia

Aaron NeimanStony Brook University

Christopher T. Beh (chair), Simon Fraser University

Enjoy reading ASBMB Today?

Become a member to receive the print edition monthly and the digital edition weekly.

Learn more
Christopher Beh
Christopher Beh

Christopher Beh is a professor of molecular genetics and cell biology at Simon Fraser University, Burnaby, Canada.

Jen Liou
Jen Liou

Jen Liou is a scholar in medical research at the University of Texas Southwestern Medical Center, Dallas, Texas.

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in Science

Science highlights or most popular articles

Cows offer clues to treat human infertility
Journal News

Cows offer clues to treat human infertility

April 23, 2024

Decoding the bovine reproductive cycle may help increase the success of human IVF treatments.

Immune cells can adapt to invading pathogens
News

Immune cells can adapt to invading pathogens

April 20, 2024

A team of bioengineers studies how T cells decide whether to fight now or prepare for the next battle.

Hinton lab maps structure of mitochondria at different life stages
Member News

Hinton lab maps structure of mitochondria at different life stages

April 20, 2024

An international team determines the differences in the 3D morphology of mitochondria and cristae, their inner membrane folds, in brown adipose tissue.

National Academies propose initiative to sequence all RNA molecules
News

National Academies propose initiative to sequence all RNA molecules

April 19, 2024

Unlocking the epitranscriptome could transform health, medicine, agriculture, energy and national security.

From the journals: JLR
Journal News

From the journals: JLR

April 19, 2024

What can you do with artificial lipoproteins? A new key to angiogenesis. Flavonoids counteract oxidative stress. Read about recent papers on these topics.

Iron could be key to treating a global parasitic disease
Journal News

Iron could be key to treating a global parasitic disease

April 16, 2024

A study has found that leishmaniasis causes body-wide changes in iron balance, leading to red blood cell damage.