Award

Smith unravels secrets of nature’s catalysts

She has won the 2022 Mildred Cohn Award in Biological Chemistry
Arti Dumbrepatil
Dec. 17, 2021

When Janet Smith was an undergraduate at Indiana University of Pennsylvania, she attended a seminar on cytochrome c structure, sequence and phylogeny. “I thought proteins were just wonderful,” she said. “I was fascinated by the structural details and how the conservation of cytochrome c sequences mapped to the 3D structure, but didn’t have an opportunity to study protein structure until I was a postdoc. It’s the discovery … Sometimes you look at a new protein structure and immediately say, ‘Oh, wow. Now I get it.’ It’s a great thrill.”

Janet Smith

Some four decades later, Smith was still busy piecing together protein structural puzzles when she learned she had won the American Society for Biochemistry and Molecular Biology’s 2022 Mildred Cohn Award in Biological Chemistry.

“It was a complete surprise, a very pleasant surprise,” she said, describing the award as “a recognition of my service activities to help advance the structural biology field.”

In her lab at the University of Michigan, Smith and her team use X-ray crystallography, notably the multi-wavelength anomalous diffraction method and its single-wavelength counterpart, known as MAD and SAD, to solve structures of proteins such as biosynthetic enzymes for natural products and primary metabolites. As a new assistant professor, her first research projects required specialized synchrotron beamlines, leading to her effort to develop high-performance beamlines for macromolecular crystallography.

“One of the most satisfying aspects of my career has been to watch my field change from ‘protein crystallography’ to ‘structural biology,’” Smith said. “I have been fortunate to see protein structure become prospective in biochemistry and molecular biology, no longer retrospective.”

Smith lectures internationally on structural biology and synchrotron radiation and mentors young women in science and young crystallographers, even if they don’t work in her lab. Mentoring is her hardest job, she said. “Science changes … and it can be difficult to choose a path in research. I advise new students to choose any experimental area where they enjoy the work, and to consider what fields they think will be strong in 20 years. And then look at the intersection. And be fearless about changing course as science — and they — change.”

Deciphering structural puzzles

Janet Smith’s lab studies the biological function of proteins at the molecular level. They use X-ray crystallography to solve protein 3D structures and then aim to explain what the proteins do and how they do it.

“We try to explain the function of a protein in terms of the 3D structure, and then test ideas about mechanism with biochemical and other experiments,” Smith said. She has used this approach to understand the mechanism and regulation of several enzymes by solving their crystal structures.

In her award lecture, “Proteins in the Interplay of Viruses as Pathogens and Us as Hosts: ‘Us vs. Them,’” Smith will discuss her recent research, she said. Her lab’s study of viral proteins has revealed some unexpected mechanisms underlying host–virus interactions and subsequent immune response mechanisms.

“I will probably talk on one or two systems that we have investigated,” she said, “and highlight the structural features of proteins that humans make to fight RNA viruses.”

Enjoy reading ASBMB Today?

Become a member to receive the print edition monthly and the digital edition weekly.

Learn more
Arti Dumbrepatil

Arti Dumbrepatil is a freelance science writer and communicator. With her academic training plus expertise in science communication and writing, she demystifies and transforms complex, jargon-filled science into enjoyable and comprehensible content that resonates with a diverse audience.

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in People

People highlights or most popular articles

Daniel E. Atkinson (1921 – 2024)
Retrospective

Daniel E. Atkinson (1921 – 2024)

May 27, 2024

Friends remember an innovative metabolic biochemist who was an ASBMB member for more than six decades.

This MOSAIC scholar’s journey brought her home to share science
Profile

This MOSAIC scholar’s journey brought her home to share science

May 23, 2024

Melissa Ramirez uses computations and experiments to design new reactions and mentorship to grow the research community.

More than just omics
Interview

More than just omics

May 21, 2024

Meet the three co-organizers of an intimate meeting that focuses on transcription from all angles.

2024 Goldwater scholars announced
Award

2024 Goldwater scholars announced

May 20, 2024

Thirteen of the scholarship recipients are ASBMB student members.

In memoriam: Edith C. Wolff
In Memoriam

In memoriam: Edith C. Wolff

May 20, 2024

She was an enzyme biochemist at the National Institutes of Health and a former assistant to the editor of the Journal of Biological Chemistry.

This MOSAIC scholar believes in the power of perseverance
Diversity

This MOSAIC scholar believes in the power of perseverance

May 16, 2024

Wagner Silva Dantas aims to develop new approaches to reducing fat mass while preserving muscle mass by studying a crucial regulator for maintaining redox balance.