Award

Farese and Walther find depth in a droplet

They have won the 2022 ASBMB–Merck Award
Renae   Crossing
Dec. 15, 2021

“Tobi was a very rare type of person. … When you do a sabbatical many people in the lab ignore you, but Tobi ... without hesitation, said, ‘I’ll help you. Let’s go.’”

Robert Farese Jr.

In this way, Tobias Walther’s simple question (“What are you working on?”) to Robert Farese Jr. started a long-term collaboration that has become the forefront research group in a new field of biology: how and why our cells make little droplets, called lipid droplets, and why that matters.

In the early 1990s, Farese had been studying enzymes that make oils. In his science, as in his photography, Farese looks deeply at everyday things others pass over. Lipid droplets had been observed under microscopes since the 1800s, but Farese said, “When I went to the textbooks and tried to learn about them as organelles, I couldn’t find anything.”

Tobias Walther

Farese and Walther converged from complementary paths: one a U.S. lipid biologist with an M.D., the other a German chemist and biochemist who was a postdoc at the time. Additionally pooling structural biology, biophysics, proteomics, enzymology and physiology, over time they created excellent science.

“We stand on the shoulders of some amazing scientists,” Walther said, “but they didn’t have the tools that we have.”

For what they’ve done with these tools, Walther and Farese, now running a joint lab at Harvard University and both associate members of the Broad Institute, have won the 2022 American Society for Biochemistry and Molecular Biology’s ASBMB–Merck Award.

Droplets by nature are isolated, but good science isn’t. For Walther, “It’s about the work and not (the two of us) … many people in our lab have contributed.” Farese attributes asking good questions to their “constant creative dialogue … ping ponging” ideas for experiments. Both buck egomania in science, appreciating a congratulatory note from mentors over a press release.

Feedback on the science itself, says Walther, is what shows “we’re on the right track.” That track increasingly has shown that there’s depth in a droplet, and there’s yet more to be found.

Two make one

Two enzymes inside us, DGAT1 and DGAT2, like Tobias Walther and Robert Farese Jr., converge with their distinct pathways to work on a common process: encasing energy-rich molecules safely in lipid droplets. (And one of them is shaped like a butterfly.) Lipids left alone to accumulate can be toxic, so it’s safer to bundle them together.

Inside lipid droplets are fats, or triacylglycerides: esters of fatty acids and glycerol. Their presence makes cells an emulsion, Farese explains, and while we know in terms of physics how emulsions form, in biochemistry, questions arise about “how nature evolved proteins and lipids to govern that process in a regulated way.”

Knowing how fats are metabolized has consequences: mutated versions of DGAT1 cause congenital diarrhea syndrome, and physicians may soon block DGAT2 to treat nonalcoholic fatty liver disease; the latter is in clinical trials. Overactive versions of DGAT enzymes will have plants and microbes producing oils for food or fuel for us.

And regarding obesity and conditions where people are underweight, Walther wants people to know, “We’re making a lot of progress, and there’s a lot of hope.”

Enjoy reading ASBMB Today?

Become a member to receive the print edition monthly and the digital edition weekly.

Learn more
Renae   Crossing

Renae Crossing is a writer and former teacher. She holds a first-class master’s degree in life science from the Hong Kong University of Science and Technology and a first-class master’s in teaching from the University of Melbourne.

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in People

People highlights or most popular articles

ASBMB delegates leave their mark on policymaking
Feature

ASBMB delegates leave their mark on policymaking

Dec. 1, 2022

Advocacy Training Program participants use their new skills to improve their institutional environments, create new programs, draft policy recommendations, perform targeted outreach and more.

2022 Sewer scholarship winners announced
Society News

2022 Sewer scholarship winners announced

Nov. 28, 2022

The $2,000 award goes to undergraduates who demonstrate an interest in the fields of biochemistry and molecular biology and enhance the diversity of science.

Brought to you (mostly) by and for women
Annual Meeting

Brought to you (mostly) by and for women

Nov. 23, 2022

The ASBMB’s Women in Biochemistry and Molecular Biology Committee has big plans for Discover BMB 2023.

Dedicated to sharing science
Student Chapters

Dedicated to sharing science

Nov. 21, 2022

Introduced to scientific research through her Tufts University ASBMB Student Chapter, Lema Abuoqab works to make sure other students can have the same experience.

Tolbert named HHMI VP; new phase for Hannun
Member News

Tolbert named HHMI VP; new phase for Hannun

Nov. 21, 2022

Awards, promotions, milestones and more. Find out what's going on in the lives of ASBMB members.

What’s in the structural vaccine designer’s toolbox?
Interview

What’s in the structural vaccine designer’s toolbox?

Nov. 17, 2022

Structural biologist Jason McLellan, a researcher at UT Austin, has been recognized widely for his work on vaccine development. We asked him about the nuts and bolts of engineering the best antigen.