Sharpee sees many ways of looking at a tree
You might not think a book called “Einstein Gravity in a Nutshell” would offer much insight into how the brain works. Tatyana Sharpee would disagree.

“For many years, this was my Saturday reading,” Sharpee said, smiling, after she pulled the book from her home office bookshelf during an interview. Nothing but the title suggests a nutshell-sized quantity of information; the tome is several inches thick and almost 900 pages long.
In a letter nominating Sharpee for the American Society for Biochemistry and Molecular Biology’s 2022 Delano Award for Computational Biosciences, fellow Salk professor Tony Hunter describes her studies as developing “a cohesive description of how biological systems strive for efficiency in information transmission at both local and network-wide scales.” A second letter from Duke neuroscientist Nicolas Brunel called her “one of the leading computational neuroscientists of her generation.”
Computational neuroscience is a fair distance from where Sharpee started. “I grew up wanting to be a physicist — that was the only option,” she said.
Her parents in Ukraine both were physicists, and her grandparents were mathematicians. She earned a Ph.D. in theoretical physics at Michigan State University before beginning a postdoc in computational neuroscience.
“The transition from physics to biology was not an easy one,” she said — not because the subject was more challenging but because stepping away from her lifelong intention to be a physicist provoked self-doubt and what she called “some kind of existential crisis.”
These days, however, she sees the switch as an opportunity to bring lessons learned in physics into a new field. “I think that’s the wonderful part about science; that you can start in one area, and then diffuse to other disciplines.”
Sharpee also derives insight from working with colleagues, whose diverse perspectives she values. “Because each one of us has a different trajectory in science, our approaches to the same problem will be different,” Sharpee said. “I hear, for example, that if you ask two photographers to photograph the same tree, the two photographs will come out very different. The same thing with scientists.”
Applying geometry to biology
Tatyana Sharpee, a professor at the Salk Institute who trained as a physicist before transitioning into computational neurosciences, uses many concepts drawn from physics and mathematics to explain biological phenomena.
One area she has found fruitful is applying hyperbolic geometry to biological questions. Hyperbolic geometry rests on parameters far removed from the Euclidean geometry most of us learn in high school. For starters, whereas in Euclidean geometry just one straight line can pass through any given point without crossing a second straight line, in hyperbolic space, infinitely many can do so.
Sharpee applies this conceptual framework to biological problems that involve compressing multidimensional information into relatively fewer dimensions — such as neural encoding of sensory input or visualizing the relationship between a disease and transcription of thousands of genes.
Receiving the DeLano award is gratifying, Sharpee said, in part because it recognizes her more recent forays from computational neuroscience into cellular and molecular biology questions.
2022 ASBMB award winners
Lea Michel, ASBMB Early Career Leadership Award
Marlene Belfort, ASBMB Mid-Career Leadership Award
Michael Airola, Walter A. Shaw Young Investigator Award in Lipid Research
Alex Toker, Avanti Award in Lipids
Tracy Johnson, Ruth Kisrchstein Diversity in Science Award
Martin Bollinger, William C. Rose Award
Joe Provost, ASBMB Award for Exemplary Contributions to Education
Walther and Robert Farese Jr., ASBMB–Merck Award
Greg Wang, ASBMB Young Investigator Award
Janet Smith, Mildred Cohn Award
Kathleen Collins, Earl and Thressa Stadtman Distinguished Scientist Award
Elaine Fuchs, Bert and Natalie Vallee Award in Biomedical Science
Susan Taylor, Herbert Tabor Research Award
John Boothroyd, Alice and C.C. Wang Award in Molecular Parasitology
Enjoy reading ASBMB Today?
Become a member to receive the print edition four times a year and the digital edition monthly.
Learn moreGet the latest from ASBMB Today
Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.
Latest in People
People highlights or most popular articles

How undergrad research catalyzes scientific careers
Undergraduate research doesn’t just teach lab skills, it transforms scientists. For Antonio Rivera and Julissa Cruz–Bautista, joining a lab became a turning point, fostering critical thinking, persistence and research identity.

Simcox and Gisriel receive mentoring award
They were honored for contributing their time, knowledge, energy and enthusiasm to mentoring postdocs in their labs.

ASBMB names 2025 Marion B. Sewer scholarship recipients
Ten undergraduates interested in biochemistry and molecular biology will each receive $2,000 toward their tuition and related educational costs.

Attie named honorary professor
This award includes $100,000 of research funding and recognizes faculty who have made major contributions to the advancement of knowledge through their research, teaching and service activities.

Meet the 2025 SOC grant awardees
Five science outreach and communication projects received up to $1,000 from ASBMB to promote the understanding of molecular life science.

Unraveling cancer’s spaghetti proteins
MOSAIC scholar Katie Dunleavy investigates how Aurora kinase A shields oncogene c-MYC from degradation, using cutting-edge techniques to uncover new strategies targeting “undruggable” molecules.