Glutathione pathway implicated in rare disease
Methylmalonic aciduria, or MMA, is a rare inherited metabolic disorder in which the body cannot break down certain amino acids and lipids. This leads to a buildup of methylmalonic acid and other metabolites in tissues and body fluids, and is associated with conditions like oxidative stress and mitochondrial dysfunction. However, MMA’s complex underlying mechanisms of action remain unresolved.
Integrative multiomics has emerged as a tool to help better understand the underlying pathogenesis of the disease. Jianbo Fu, Sandra Goetze and a team of researchers in Switzerland provide an analysis framework to integrate complex data types. They published their framework in Molecular & Cellular Proteomics.
The team obtained DNA, RNA, protein and metabolite information from MMA patients. Using their multiomics framework, which links genetic variants to protein levels, they identified glutathione metabolism as a central pathway in MMA pathogenesis.
This study illustrates how multiomics approaches can reveal underlying mechanisms in complex diseases, highlighting potential targets for future therapeutic strategies.
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