A Year of (Bio)chemical Elements

For April, it’s copper — atomic No. 29

Quira Zeidan
April 1, 2019

Oxygen-bound copper, represented by the two orange spheres in the center of the structure of the protein hemocyanin, gives arthropod hemolymph a blue color. Jawahar Swaminathan & MSD staff / European Bioinformatics Institute 2019 marks the 150th anniversary of the first publication of Dimitri Mendeleev’s periodic table of chemical elements. To honor the occasion, each month we are focusing on elements important in biochemistry. In January and February, we featured hydrogen and iron, respectively, and in March, we tripled down with sodium, potassium and chlorine.

Copper

For April, we have selected copper, a transition metal with chemical symbol Cu and atomic number 29. Copper participates in chemical reactions via a wide range of oxidation numbers from -2 to +4 but most commonly is found in organic cuprous and cupric complexes with oxidation states of +1 and +2, respectively.

Ancient civilizations used copper extensively in the manufacture of ornaments, weapons and tools, and the late fifth millennium BC is the archeological period known as the Copper Age.

Copper most likely forms during the expansion of supergiant stars and makes up about 0.0068 percent of the Earth’s crust. In nature, it occurs in its pure metallic form as native copper or in combination with other elements in minerals containing copper oxides, copper sulfides or copper carbonates. These minerals form when volcanic activity separates copper from magma and the copper reacts explosively with ascending sulfurous gases, precipitating beneath the surface as copper-rich ores.

After iron and zinc, copper is the third most abundant metallic element in biological systems. Copper is indispensable for most living organisms in trace amounts, but it can produce highly reactive toxic species when found in excess inside cells. Microorganisms can mobilize solid copper by incorporating it into cyanide compounds, and copper-binding proteins in the periplasmic space allow bacteria to trap copper to avoid intracellular toxicity. In yeast, cell surface metalloreductases render copper available to high-affinity transporter proteins by reducing Cu+2 to Cu+1. Fungi that colonize the roots of host plants protect them from toxicity by trapping soiled or soluble copper in compounds with other metals.

Once in cells, copper binds to proteins that participate in electron transfer reactions or oxygen transportation. In the mitochondrial respiratory chain, a binuclear copper center in cytochrome c oxidase transfers electrons from cytochrome c to molecular oxygen in the final redox step of the oxidative phosphorylation pathway. Similarly, a copper-containing protein called plastocyanin in the thylakoid lumen of chloroplasts carries electrons between two membrane-bound proteins — cytochrome f and P700+ — during photosynthesis.

Like hemoglobin in vertebrates, a copper-containing protein called hemocyanin transports oxygen in the hemolymph of invertebrates, such as mollusks and some arthropods. When a molecule of oxygen binds two copper atoms in hemocyanin, copper is oxidized from Cu+1 to Cu+2, and the energy associated with this electron transfer changes the light-absorbing properties of copper. This causes oxygen-rich hemolymph in these animals to appear blue in contrast to the bright red color of oxygen-bound iron in hemoglobin.

In eukaryotes, the antioxidant enzyme superoxide dismutase uses copper to catalyze the decomposition of the superoxide radical into molecular oxygen and hydrogen peroxide, which are less toxic to the cell.

Thus, from the heart of volcanoes to the relay of electrons inside cells, copper is critical to the survival of all aerobic organisms.

Enjoy reading ASBMB Today?

Become a member to receive the print edition four times a year and the digital edition monthly.

Learn more
Quira Zeidan

Quira Zeidan is the ASBMB’s education and public outreach coordinator.

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in Science

Science highlights or most popular articles

Receptor antagonist reduces age-related bone loss in mice
Journal News

Receptor antagonist reduces age-related bone loss in mice

Aug. 6, 2025

Receptor antagonist reduces bone loss and promotes osteoblast activity in aging mice, highlighting its potential to treat osteoporosis. Read more about this recent JBC paper.

Engineered fusion protein targets kiwifruit pathogen
Journal News

Engineered fusion protein targets kiwifruit pathogen

Aug. 6, 2025

Synthetic protein selectively kills kiwifruit pathogen, offering a promising biocontrol strategy for agriculture. Read more about this recent JBC paper.

Pathogen-derived enzyme engineered for antibiotic design
Journal News

Pathogen-derived enzyme engineered for antibiotic design

Aug. 6, 2025

Engineered variants of a bacterial enzyme developed at the University at Buffalo accept larger substrates, paving the way for new acinetobactin-based antimicrobials. Read more about this recent JBC paper.

Omega-3 fats linked to healthy aging and improved heart metabolism
Journal News

Omega-3 fats linked to healthy aging and improved heart metabolism

Aug. 1, 2025

Scientists from the University of Iowa find that a diet high in polyunsaturated fatty acids from fish oil increases cardiac triglyceride uptake and improves insulin sensitivity. Read more about this recent JLR study.

RA patient blood reveals joint innerworkings
Journal News

RA patient blood reveals joint innerworkings

July 25, 2025

Researchers in the Netherlands use mass spectrometry to compare the proteome of plasma and synovial fluid in rheumatoid arthritis patients and find a correlation. Read more about this recent paper in Molecular & Cellular Proteomics.

Hope for a cure hangs on research
Essay

Hope for a cure hangs on research

July 17, 2025

Amid drastic proposed cuts to biomedical research, rare disease families like Hailey Adkisson’s fight for survival and hope. Without funding, science can’t “catch up” to help the patients who need it most.