New insights into how cells respond to altered gravity experienced in space
A new study has revealed insights into how cells sense and respond to the weightlessness experienced in space. The information could be useful for keeping astronauts healthy on future space missions.

The gravity conditions in space, known as microgravity, trigger a unique set of cellular stress responses. In the new work, researchers found that the protein modifier SUMO plays a key role in cellular adaptation to simulated microgravity.
“Under normal gravity conditions, SUMO is known to respond to stress and to play a critical role in many cellular processes, including DNA damage repair, cytoskeleton regulation, cellular division and protein turnover,” said research team leader Rita Miller, a professor of biochemistry and molecular biology at Oklahoma State University in Stillwater. “This is the first time that SUMO has been shown to have a role in the cell’s response to microgravity.”
Jeremy Sabo, a graduate student in Miller’s laboratory, will present the findings at Discover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology, March 25–28 in Seattle.
SUMO can interact with proteins via two types of chemical bonds: a covalent attachment to a target lysine or noncovalent interactions with a binding partner. The researchers looked at both types of interactions in yeast cells, a model organism commonly used to study cellular processes. They analyzed cells that had undergone six cellular divisions in either normal Earth gravity or microgravity simulated using a specialized cell culture vessel developed by NASA.

To understand which cellular processes were affected by the stress of microgravity, they began by comparing the levels of protein expression for cells that experienced each gravity condition. Then, to find out what was driving these protein changes, they looked more specifically at which of these proteins interacted with SUMO using mass spectroscopy.
In the cells experiencing microgravity, the researchers identified 37 proteins that physically interacted with SUMO and showed expression levels that differed from that of the Earth gravity cells by more than 50%. These 37 proteins included ones that are important for DNA damage repair, which is notable because radiation damage is a serious risk in space. Other proteins were involved in energy and protein production as well as maintaining cell shape, cell division and protein trafficking inside cells.
“Since SUMO can modify several transcription factors, our work may also lead to a better understanding of how it controls various signaling cascades in response to simulated microgravity,” said Miller.
Next, the researchers want to determine whether the absence of the SUMO modification on specific proteins is harmful to the cell when it is subjected to simulated microgravity.
Jeremy Sabo will present this research from 4–5:30 p.m. PDT on Tuesday, March 28, in Exhibit Hall 4AB of the Seattle Convention Center (Poster Board Number 330) (abstract). Contact the media team for more information or to obtain a free press pass to attend the meeting.
Enjoy reading ASBMB Today?
Become a member to receive the print edition four times a year and the digital edition monthly.
Learn moreGet the latest from ASBMB Today
Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.
Latest in Science
Science highlights or most popular articles

A biological camera: How AI is transforming retinal imaging
AI is helping clinicians see a more detailed view into the eye, allowing them to detect diabetic retinopathy earlier and expand access through tele-ophthalmology. These advances could help millions see a clearer future.

AI in the lab: The power of smarter questions
An assistant professor discusses AI's evolution from a buzzword to a trusted research partner. It helps streamline reviews, troubleshoot code, save time and spark ideas, but its success relies on combining AI with expertise and critical thinking.

Training AI to uncover novel antimicrobials
Antibiotic resistance kills millions, but César de la Fuente’s lab is fighting back. By pairing AI with human insight, researchers are uncovering hidden antimicrobial peptides across the tree of life with a 93% success rate against deadly pathogens.

AI-designed biomarker improves malaria diagnostics
Researchers from the University of Melbourne engineered Plasmodium vivax diagnostic protein with enhanced yield and stability while preserving antibody-binding, paving the way for more reliable malaria testing.

Matrix metalloproteinase inhibitor reduces cancer invasion
Scientists at the Mayo Clinic engineered a TIMP-1 protein variant that selectively inhibits MMP-9 and reduces invasion of triple-negative breast cancer cells, offering a promising tool for targeted cancer research.

Antibiotic sensor directly binds drug in resistant bacteria
Researchers at Drexel University uncover how the vancomycin-resistant bacterial sensor binds to the antibiotic, offering insights to guide inhibitor design that restores antibiotic effectiveness against hospital-acquired infections.