News

Eye-opening origin story

Scientists trace key innovation in our camera-like vision to bacteria
Mario Aguilera
By Mario Aguilera
June 29, 2023

Humans and other organisms with backbones come equipped with an evolutionary marvel: eyes that function like cameras to provide a finely tuned visual system. Due to its complexity, Charles Darwin described the eye as one of the greatest potential challenges to his theory of natural selection through incremental evolutionary steps.

Jenessa Daugherty

A notable difference between vertebrate and invertebrate vision is rooted in a unique protein responsible for the specialization of cells that are critical for vision. Mutations in the protein, called the interphotoreceptor retinoid-binding protein, or IRBP, have been known to cause a variety of diseases such as retinitis pigmentosa, but its evolutionary origin has remained elusive with no obvious genetic precursor.

Scientists in the University of California San Diego School of Biological Sciences, publishing in the Proceedings of the National Academy of Sciences, have now traced the 500-million-year-old origin of vertebrate IRBP to a bacterial source. Their discovery, using phylogenetic reconstruction methods, was made possible because of the growing number of fully detailed genomes now available. Their analysis of more than 900 genomes across the tree of life revealed that the IRBP integration in vertebrate eyes was not the result of traditional vertical gene transfer, in which an evolutionary advancement is adapted, or “tinkered with” using available genetic material. Rather, the IRBP was acquired, duplicated and integrated through horizontal gene transfer from foreign bacterial genes.

Researchers compared the structure of vertebrate IRBP (blue) with a predicted structure of a similar gene in bacteria.
Researchers compared the structure of vertebrate IRBP (blue) with a predicted structure of a similar gene in bacteria.

“It’s a massive shift because this is an entirely new piece of genetic material that’s been introduced from bacteria,” said Associate Professor Matt Daugherty, the paper’s senior author. Former UC San Diego undergraduate student Chinmay Kalluraya led the study, and UC San Diego graduate students Alexander Weitzel and Brian Tsu contributed computational expertise. “This study shows that a major innovation that distinguishes vertebrate eyes from all the rest of the eyes out there wasn’t done by molecular tinkering but rather a big leap of genetic innovation.”

Once the key gene that eventually became IRBP was acquired from bacteria, a new door opened in vertebrates that allowed retinoids, molecules in the eye that directly sense light, to be shuttled between cell types to efficiently recycle it for further light sensing. This separation of photoreception, or light sensing, and retinoid recycling provides unique functionality to vertebrates and the way they can see.

A schematic of the vertebrate visual cycle highlighting the physical separation of light sensing.
A schematic of the vertebrate visual cycle highlighting the physical separation of light sensing.

“In order to see in different wavelengths, there needs to be enough light around and that’s one of the arguments for why we can see in the dark really well—we have this enzymatic recycling system that many invertebrates don’t seem to have,” said Daugherty, a researcher in the molecular biology department. “Eyes are diverse and complicated, and we’ve gone down this path because of this system.”

With more genomes from more organisms becoming available, the researchers believe that other critical functions and systems will similarly trace their roots to bacteria.

“This reshapes the way that we think about evolution and the way we think about complex structures that seem like they’ve emerged out of nowhere,” said Daugherty.

This article first appeared in UC San Diego Today. Read the original.

Enjoy reading ASBMB Today?

Become a member to receive the print edition monthly and the digital edition weekly.

Learn more
Mario Aguilera
Mario Aguilera

Mario Aguilera is the director of communications for UC San Diego’s School of Biological Sciences. In this role, he coordinates communication strategies and publicizes research and other features through news releases, articles, interviews, videos and social media. He also serves as co-leader of the campus' Research Communications Program, which trains scientists to clearly and effectively communicate their research to public audiences.

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in Science

Science highlights or most popular articles

Universal tool for tracking cell-to-cell interactions
News

Universal tool for tracking cell-to-cell interactions

May 19, 2024

A team of researchers has developed LIPSTIC, which can lay the groundwork for a dynamic map tracking physical interactions between different cells — the elusive cellular interactome.

Weedy rice gets competitive boost from its wild neighbors
News

Weedy rice gets competitive boost from its wild neighbors

May 18, 2024

Rice feeds the world. But researchers have found that a look-alike weed has many ways of getting ahead.

From the journals: JLR
Journal News

From the journals: JLR

May 17, 2024

A “T” makes a difference in blood clotting. High cholesterol: two screens are better than one. Biomarkers for cardiovascular risk. Statin-induced changes to the HDL lipidome. Read about recent papers on these topics.

Decoding microglial language
Journal News

Decoding microglial language

May 14, 2024

Emory University scientists characterize extracellular vesicles that facilitate intercellular communication.

What is metabolism?
News

What is metabolism?

May 12, 2024

A biochemist explains how different people convert energy differently – and why that matters for your health.

What’s next in the Ozempic era?
News

What’s next in the Ozempic era?

May 11, 2024

Diabetes, weight loss and now heart health: A new family of drugs is changing the way scientists are thinking about obesity — and more uses are on the horizon.