
Mining millets
Millets are ancient grains and cereals with origins in Africa, the Middle East and Asian countries including China and India, where they are food staples. In addition to growing in harsh environments and enduring drought or attacks by pests, millets are often less processed and yield higher nutritional benefits than grains such as corn, rice and wheat.

Those conventional grains of the Western diet are well studied, but scientists know little about the bioactive food species in major and minor millets, including the distribution of lipids, or fat-soluble compounds; the composition of fatty acids, or lipid building blocks; and the presence of nutraceuticals, or substances in millets and food that benefit physiological health.
Sugasini Dhavamani, a research assistant professor at the University of Illinois at Chicago, and her team have studied the nutri-lipidomic profiles of major and minor millet seeds and oils.
“I am passionate about lipid research,” Dhavamani said, “I love working at the University of Illinois because we have amazing equipment and facilities, and great means for collaboration.”
The oils of grains are not commercially available, so the researchers first extracted lipids from the millets, then analyzed samples using high-performance liquid chromatography and gas chromatography-mass spectrometry.
“The oil extraction takes time,” Dhavamani said, adding that the researchers face other challenges. “After extraction we often get a low quantity of lipids, which can also cause difficulty. Stability is a concern because the lipids are easily oxidized.”

After profiling sorghum millet, little millet, finger millet, proso millet, kodo millet, pearl millet and foxtail millet, Dhavamani and colleagues found that oleic acid, linoleic acid and alpha-linoleic acid, or omega-9,-6 and -3, are the three major fatty acid species present in millets and seed oils.
“Most of the millets evaluated contained omega-9 and omega-6 and a small amount of omega-3 fatty acids, which help to lower cholesterol and blood pressure levels, and can benefit chronic disease,” Dhavamani said. “Millets also have nutraceuticals, which are helpful for lowering inflammation.”
In the future, the researchers want to expand this work into animal models, where Dhavamani can assess the health benefits of millet consumption, followed by examining proteomics and metabolomics of millets; however, experiments of this scale require increased funding.
Details
Sugasini Dhavamani will present this research from 5:30 to 6:30 p.m. CDT on Sunday, March 24, at Discover BMB 2024, the American Society for Biochemistry and Molecular Biology annual meeting in San Antonio. Her poster will be at board 326.
Abstract title: Nutri-lipidomics, bioactive lipids and antioxidant potential of major and minor millet seed and oil — a novel approach
Enjoy reading ASBMB Today?
Become a member to receive the print edition four times a year and the digital edition monthly.
Learn moreGet the latest from ASBMB Today
Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.
Latest in Science
Science highlights or most popular articles

How signals shape DNA via gene regulation
A new chromatin isolation technique reveals how signaling pathways reshape DNA-bound proteins, offering insight into potential targets for precision therapies. Read more about this recent MCP paper.

A game changer in cancer kinase target profiling
A new phosphonate-tagging method improves kinase inhibitor profiling, revealing off-target effects and paving the way for safer, more precise cancer therapies tailored to individual patients. Read more about this recent MCP paper.

How scientists identified a new neuromuscular disease
NIH researchers discover Morimoto–Ryu–Malicdan syndrome, after finding shared symptoms and RFC4 gene variants in nine patients, offering hope for faster diagnosis and future treatments.

Unraveling cancer’s spaghetti proteins
MOSAIC scholar Katie Dunleavy investigates how Aurora kinase A shields oncogene c-MYC from degradation, using cutting-edge techniques to uncover new strategies targeting “undruggable” molecules.

How HCMV hijacks host cells — and beyond
Ileana Cristea, an ASBMB Breakthroughs webinar speaker, presented her research on how viruses reprogram cell structure and metabolism to enhance infection and how these mechanisms might link viral infections to cancer and other diseases.

Understanding the lipid link to gene expression in the nucleus
Ray Blind, an ASBMB Breakthroughs speaker, presented his research on how lipids and sugars in the cell nucleus are involved in signaling and gene expression and how these pathways could be targeted to identify therapeutics for diseases like cancer.