Journal News

MCP: When mitochondria make B cells go bad

John Arnst
Feb. 1, 2018

B-cell chronic lymphocytic leukemia, or B-CLL, is the most common type of leukemia in adults and primarily affects elderly patients. The disease results from a patient’s bone marrow overproducing immature lymphocytes, a form of white blood cells that fight infections less effectively than their healthy counterparts but survive longer, ultimately overwhelming them and spreading unchecked. Unlike acute leukemia, B-CLL can take several years to cause problems for a patient, but it is less responsive to chemotherapy.

When mitochondria, highlighted here in cow cells, suffer age-related oxidative damage, they can give rise to chronic lymphocytic leukemia.courtesy of Torsten Wittmann, University of California, San Francisco

While novel treatments have been developed in recent years, they only target the B cells once they’ve mutated to an immature, cancerous state. To develop treatments for B-CLL that might prevent B cells from becoming cancerous in the first place, researchers led by Christopher Gerner at the University of Vienna and Vienna Metabolomics Center have performed a comprehensive proteomics analysis of B-CLL cells and mature B cells in young and elderly patients. They described their work in a paper in the journal Molecular & Cellular Proteomics.

“It could be nice to not only target the cancer cells, but those cells prone to becoming cancer cells,” Gerner said. “What we actually saw when we compared the young and the elderly donors was a very clear signature of mitochondrial stress and metabolic stress.”

Gerner and colleagues found that B-CLL cells have an increased expression of stem cell-associated molecules and a reduced expression of tumor-suppressing molecules and stress-related serotonin transporters as well as an observed increase in glutamine consumption and beta-oxidation of fatty acid.

This indicated that reactive oxidative species, which are carcinogenic and cause damage to cells, were being upregulated, Gerner said, which would explain why the incidence of mutations that lead to B-CLL increases with age. The researchers hope that the alterations in regulation also may provide a proteomic signature for immunosenescence, the immune system’s natural weakening with age.

Gerner and his fellow researchers plan to continue this research by performing their proteomic analysis on blood samples taken from greater numbers of healthy elderly people and B-CLL patients to ultimatelybe able to test when mitochondria have become predisposed for the disease.

“The pressure on those cells was simply different … and this pressure is something I would like to detect and measure in patients,” Gerner said. “That would be the ultimate aim.”

John Arnst

John Arnst was a science writer for ASBMB Today.

Related articles

From the journals: MCP
Nuala Del Piccolo
From the journals: MCP
Nuala Del Piccolo & Laurel Oldach
From the journals: MCP
Kian Kamgar-Parsi
From the journals: MCP
Nivedita Uday Hegdekar

Join the ASBMB Today mailing list

Sign up to get updates on articles, interviews and events.

Latest in Science

Science highlights or most popular articles

The impacts of COVID-19 on women’s physical health
Health Observance

The impacts of COVID-19 on women’s physical health

May 11, 2021

Pregnancy, periods, long COVID and side effects: lots of questions remain unanswered.

An abundance of potential
Observance

An abundance of potential

May 10, 2021

For National Lipid Day, a new contributor offers a glance at what yeast might yield.

Astrocyte cells in the fruit fly brain are an on-off switch
News

Astrocyte cells in the fruit fly brain are an on-off switch

May 9, 2021

Adaptable neurons are tied to learning and memory but also to neurological disorders. By studying fruit flies, researchers found a mechanism that controls neuroplasticity.

Part 1: ‘Aha moments’ essay contest honorable mentions
Contest

Part 1: ‘Aha moments’ essay contest honorable mentions

May 6, 2021

To celebrate our three journals going open access, we invited readers to share their moments of discovery in science. Here are two honorable mentions.

From the journals: MCP
Journal News

From the journals: MCP

May 6, 2021

Using silver nanoparticles to target cancer. Glycosylation of SARS-CoV-2. Characterizing the glycan signature in tumor tissue. Read about recent papers in the journal Molecular & Cellular Proteomics.

Ceramides’ role in liver disease
Lipid News

Ceramides’ role in liver disease

May 5, 2021

These biologically active sphingolipids have roles in apoptosis, inflammation and insulin resistance, all critical factors in the pathogenesis of chronic liver disease.