My cat’s coat is mostly white with dark tabby patches. What’s going on?
Have you ever wondered why your cat’s coat looks the way it does? Wonder no longer! Earlier this month, Emily Summerbell, a PhD student at Emory University, tweeted a ‘tweetorial’ on cat coat genetics. I used it to figure out the underlying genetics for my own cat’s coat.
This is my cat ‘Little Excuse’ (because when he’s sleeping on your lap, you’ve got an excuse to not get up).
Excuse has a short coat, which is controlled by the FGF5 gene. Short hair (L) is the dominant trait, meaning that if one out of two copies, or alleles, of the gene encodes for short hair, the cat will end up with short hair. Excuse is either homozygous, meaning he has two short hair alleles (LL), or heterozygous, meaning he has one short hair, and one long hair allele (Ll).
Though Excuse is for the majority white (we’ll get back to that later), he generally has dark-colored fur. This is encoded by the TYRP1 gene, for which the black allele is dominant. If he would have the allele for orange hair, this would override the black color, so the lack of any orange means that he has the recessive allele for the orange gene.
Back to the white fur. White fur is caused by the KIT gene, but it is not all-or-nothing. As you can see, Excuse is more than 50% white, which indicates that he is probably homozygous for the dominant white gene (SS).
Lastly, although it’s not clearly visible in this picture, Excuse’s dark patches have a tabby pattern to them. This is caused by the agouti and tabby genes, where the agouti gene determines whether a cat has a solid color coat, and the tabby gene determines the exact pattern.
Emily goes into much more detail in her Twitter thread, explaining colorpoint coat patterns, cats with diluted colors and more. If you are wondering why your cat looks the way it does, this thread will tell you all you need to know.
But in the meantime, what colour is your cat’s coat — and do you know why?
Enjoy reading ASBMB Today?
Become a member to receive the print edition four times a year and the digital edition monthly.
Learn moreGet the latest from ASBMB Today
Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.
Latest in Science
Science highlights or most popular articles

Life in four dimensions: When biology outpaces the brain
Nobel laureate Eric Betzig will discuss his research on information transfer in biology from proteins to organisms at the 2026 ASBMB Annual Meeting.

Fasting, fat and the molecular switches that keep us alive
Nutritional biochemist and JLR AE Sander Kersten has spent decades uncovering how the body adapts to fasting. His discoveries on lipid metabolism and gene regulation reveal how our ancient survival mechanisms may hold keys to modern metabolic health.

Redefining excellence to drive equity and innovation
Donita Brady will receive the ASBMB Ruth Kirschstein Award for Maximizing Access in Science at the ASBMB Annual Meeting, March 7–10, just outside of Washington, D.C.

Mining microbes for rare earth solutions
Joseph Cotruvo, Jr., will receive the ASBMB Mildred Cohn Young Investigator Award at the ASBMB Annual Meeting, March 7–10, just outside of Washington, D.C.

Fueling healthier aging, connecting metabolism stress and time
Biochemist Melanie McReynolds investigates how metabolism and stress shape the aging process. Her research on NAD+, a molecule central to cellular energy, reveals how maintaining its balance could promote healthier, longer lives.

Mapping proteins, one side chain at a time
Roland Dunbrack Jr. will receive the ASBMB DeLano Award for Computational Biosciences at the ASBMB Annual Meeting, March 7–10, just outside of Washington, D.C.