Our internal ecology
According to a recent estimate, if you sample enough humans’ intestines, almost 40,000 types of microbe can be found. Any individual may have 100 trillion individual micro-organisms in one or two thousand taxonomic groups. How does the microbiome maintain such diversity?
One model to explain the enormous variety borrows from studies of larger ecosystems. A well-known theory in ecology, nonequilibrium coexistence of competitors, suggests that as an environment fluctuates, different species gain an edge over neighbors — but their ascendance rarely lasts long.
Intestinal nutrients fluctuate as the human host eats and excretes, in time with the physiology of sleep–wake cycles, and along the length of the gut. A layer of mucus that protects host cells from commensal microbes introduces new oligosaccharides as a fuel source and also separates microbial communities into mucosal and luminal niches. As conditions change, species in the microbiome shift in abundance and jockey for survival, and the constantly changing competitive edge keeps the ecosystem diverse.
According to University of Ottawa postdoctoral fellow Leyuan Li, the time is ripe for microbiome studies to apply population modeling and systems dynamics from macroecology to this more intimate ecosystem.
“Most of the time we study the gut microbiome as a whole: We sequence one sample as if it were representative of our whole gut,” said Li. “The gut is actually a heterogeneous system … so we need to start thinking about the gut microbiome like a rainforest.”
Li, who conducted her Ph.D. studies building artificial ecosystems, now studies gut microbiome dynamics in health and diseases such as inflammatory bowel disease in the lab of Ottawa professor Daniel Figeys. In a recent review in the journal Molecular & Cellular Proteomics, the pair offer an introduction to microbiome ecology.
The review highlights the potential for metaproteomics, which characterizes the proteins of whole communities of microbes, to describe microbial function. Most microbiome studies use metagenomics, ribosomal RNA sequencing of the mixed population of a microbial community, to identify the bacteria, fungi and archaea that are present. Li thinks metaproteomics also may help researchers road-test increasingly popular ex vivo experimental models of the microbiome to make sure they match up to the real thing.
“Using metagenomics, you know who are there and what they can do,” Li said. “With metaproteomics you know who are there and what they are doing.”
Enjoy reading ASBMB Today?
Become a member to receive the print edition four times a year and the digital edition weekly.
Learn moreGet the latest from ASBMB Today
Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.
Latest in Science
Science highlights or most popular articles
Cracking the recipe for perfect plant-based eggs
It involves finding just the right proteins. With new ingredients and processes, the next generation of substitutes will be not just more egg-like, but potentially more nutritious.
MSU researchers leverage cryo-EM for decades-in-the-making breakthrough
Lee Kroos and Ben Orlando have reported the first high-resolution experimentally determined structures of the intramembrane protease SpolVFB.
From the Journals: MCP
Rapid and precise SARS-CoV-2 detection using mass spec. Mapping brain changes from drug addiction. Decoding plant osmotic stress response. Read about recent MCP papers on these topics.
What seems dead may not be dead
Vincent Tagliabracci will receive the Earl and Thressa Stadtman Distinguished Scientist Award at the ASBMB Annual Meeting, April 12–15 in Chicago.
'You can't afford to be 15 years behind the parasite'
David Fidock will receive the Alice and C.C. Wang Award in Molecular Parasitology at the 2025 ASBMB Annual Meeting, April 12–15 in Chicago.
Elucidating how chemotherapy induces neurotoxicity
Andre Nussenzweig will receive the Bert and Natalie Vallee Award at the 2025 ASBMB Annual Meeting, April 12–15 in Chicago.