Award

Thompson honored as ‘exemplary scientist’ in cancer biology

He won ASBMB's Vallee Award in Biomedical Science
Isha Dey
April 1, 2019

Craig B. Thompson, president and CEO of Memorial Sloan Kettering Cancer Center, is the recipient of the American Society for Biochemistry and Molecular Biology’s 2019 Bert and Natalie Vallee Award in Biomedical Science. The award honors an established scientist for outstanding accomplishments in basic biomedical research. Thompson’s lab studies cancer cell metabolism.

Craig Thompson
“I am honored to receive this recognition from the American Society for Biochemistry and Molecular Biology and to be recognized among those who have previously won this award. I wish to thank the Vallee Foundation for their commitment to championing basic biomedical science, and the Society for recognizing my lab’s work on cancer metabolism.”

— Craig Thompson

Thompson is a pioneer in the field of cancer biology. His findings have challenged existing notions about mammalian cell metabolism and its regulation. Contrary to earlier findings that mammalian cells take up nutrients autonomously, Thompson demonstrated that growth factor signaling is essential for glucose and amino acid uptake by cells for ATP synthesis. Without growth factors and hormones, cells ultimately undergo apoptosis. However, oncogenic transformation of mammalian cells alters the regulation of cellular metabolism. Due to activation of the oncogene Myc, cancer cells switch to using glutamine instead of glucose as an energy source. This allows glucose metabolites to be directed to nucleotide synthesis, which aids in uncontrolled cell proliferation.

Thompson’s group showed how mutations in genes coding for metabolic enzymes lead to several forms of cancer. Over the years, his work has established beautifully how cellular metabolism regulates signal transduction and gene expression and how oncogenic transformation alters these mechanisms. He also has contributed to the development of treatment for autoimmune diseases.

Joan Massagué, director of the Sloan Kettering Institute, nominated Thompson for the award. “Dr. Thompson’s research elucidating cancer cell metabolism is pioneering, visionary and of outstanding quality,” Massagué wrote in his nomination letter. “He has established a reputation as one of the most thoughtful and accomplished investigators in the field of cancer research.”

Thompson received his undergraduate degree in biochemistry from Dartmouth College in 1974, followed by a medical degree at the University of Pennsylvania in 1977. He served as medical officer at the Naval Blood Research Institute and National Naval Medical Center before being appointed an assistant professor of medicine and microbiology and immunology at the University of Michigan. He went on to become a professor in the departments of medicine and molecular genetics and cell biology at the University of Chicago, an investigator at the Howard Hughes Medical Institute, and then a professor and chair of the department of cancer biology at the University of Pennsylvania. In 2010, he was appointed president and CEO of Memorial Sloan Kettering Cancer Center.

Thompson has co-authored more than 400 peer-reviewed articles, has been cited more than 93,000 times and holds 30 patents. He also serves in leadership positions at various scientific organizations.

As the Vallee award recognizes outstanding achievements in sciences basic to medicine, Thompson fits the bill as a “champion of cancer research,” Massagué wrote in his nomination letter.

Enjoy reading ASBMB Today?

Become a member to receive the print edition monthly and the digital edition weekly.

Learn more
Isha Dey

Isha Dey is a scientist at Thermo Fisher Scientific.

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in People

People highlights or most popular articles

How to run an ASBMB Student Chapter
Interview

How to run an ASBMB Student Chapter

Sept. 27, 2023

A conversation with John Tansey, a professor at Otterbein University and adviser to the winner of the 2023 ASBMB Outstanding Chapter Award.

Top reviewers at ASBMB journals
Observance

Top reviewers at ASBMB journals

Sept. 26, 2023

Editors recognize the heavy-lifters and rising stars during Peer Review Week.

NAS elects new members
Member News

NAS elects new members

Sept. 25, 2023

The National Academy of Sciences recognized these ASBMB members for their distinguished and continued achievements in original scientific research.

In memoriam: Tadashi Inagami
In Memoriam

In memoriam: Tadashi Inagami

Sept. 25, 2023

He was an emeritus professor at Vanderbilt University known for his pioneering research into the causes of hypertension, heart failure and vascular disease.

Meet Sarah O’Connor
Interview

Meet Sarah O’Connor

Sept. 21, 2023

This JBC associate editor scouts the plant kingdom for intriguing pathways and hits the hiking trails in Germany.

Shedding light on Usher syndrome
Health Observance

Shedding light on Usher syndrome

Sept. 16, 2023

On this awareness day, learn about the most common cause of genetic deaf–blindness and those it affects.