Tube worm slime displays long-lasting, self-powered glow
When threatened, the marine parchment tube worm secretes a sticky slime that emits a unique long-lasting blue light. New research into how the worm creates and sustains this light suggests that the process is self-powered.
“The light, or bioluminescence, produced by this worm does not appear as flashes, like in most luminous organisms, but as a long-lasting glow,” said Evelien De Meulenaere, a researcher in Dimitri Deheyn’s lab at the Scripps Institution of Oceanography. “Understanding the mechanisms of this bioluminescence process could inform the design of a light stick that works for several days or, with further optimization, environmentally friendly garden and street lighting.”
De Meulenaere was scheduled to present this research at the American Society for Biochemistry and Molecular Biology annual meeting in San Diego in April. Though the meeting, to be held in conjunction with the 2020 Experimental Biology conference, was canceled in response to the COVID-19 outbreak, the research team's abstract was published in The FASEB Journal.

After discovering that light production was not linked with any of the organism’s metabolic pathways, the researchers realized that sustaining light production for more than a few milliseconds would require the slime to contain its own energy source.
Further work revealed that the worm’s slime contains an iron storage protein called ferritin. Artificially adding iron to the mucus increased light production, which led the researchers to believe that ferritin acts as like a molecular battery that stores energy. More recently, they found that exposing ferritin to blue light makes more iron available and that exposing the slime to blue light induces bursts of light lasting several minutes.
“A light source based on this mechanism could be remotely triggered using blue light to initiate and amplify the process,” De Meulenaere said. “Once we understand exactly how light production happens in the natural system, that information could potentially be used to develop a long-lasting light that is also biodegradable and rechargeable.”
The tube worm’s bioluminescence could also be used to create biomedical reporter systems. Because it is sensitive to iron such a system could be used to test for iron deficiencies or toxicities. It could also be used as a light-emitting reporter that works for several days. This would allow experiments where various proteins or cells are tracked for much longer periods of time than possible with today’s fluorescent reporters.
Enjoy reading ASBMB Today?
Become a member to receive the print edition four times a year and the digital edition monthly.
Learn moreGet the latest from ASBMB Today
Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.
Latest in Science
Science highlights or most popular articles

Teaching AI to listen
A computational medicine graduate student reflects on building natural language processing tools that extract meaning from messy clinical notes — transforming how we identify genetic risk while redefining what it means to listen in science.

Early lipid changes drive retinal degeneration in Zellweger spectrum disorder
Lipid profiling in a rare disease mouse model reveals metabolic shifts and inflammation in the retinal pigment epithelium — offering promising biomarker leads to combat blindness.

How sugars shape Marfan syndrome
Research from the University of Georgia shows that Marfan syndrome–associated fibrillin-1 mutations disrupt O glycosylation, revealing unexpected changes that may alter the protein's function in the extracellular matrix.

What’s in a diagnosis?
When Jessica Foglio’s son Ben was first diagnosed with cerebral palsy, the label didn’t feel right. Whole exome sequencing revealed a rare disorder called Salla disease. Now Jessica is building community and driving research for answers.

Peer through a window to the future of science
Aaron Hoskins of the University of Wisconsin–Madison and Sandra Gabelli of Merck, co-chairs of the 2026 ASBMB annual meeting, to be held March 7–10, explain how this gathering will inspire new ideas and drive progress in molecular life sciences.

Glow-based assay sheds light on disease-causing mutations
University of Michigan researchers create a way to screen protein structure changes caused by mutations that may lead to new rare disease therapeutics.