Award

Taylor honored for work
on protein kinase A

She won the ASBMB's Earl and Thressa Stadtman Award
Dawn Hayward
April 1, 2017

Susan S. Taylor, professor of chemistry and biochemistry as well as pharmacology at the University of California, San Diego, has won the 2017 American Society for Biochemistry and Molecular Biology Earl and Thressa Stadtman Distinguished Scientist Award. Taylor has done pioneering structural studies of protein kinase A, revealing fundamental themes for all protein kinases.

Susan S. Taylor

“I was thrilled and deeply honored to receive the news from Natalie Ahn that I had been selected for the 2017 Earl and Thressa Stadtman Award. Although I have never worked in Dr. Earl Stadtman’s lab, I have always considered him to be a close friend and would visit with him every time that I came to NIH. Earl and Thressa are both role models for future generations.”

Susan S. Taylor

In 1991, the Taylor group solved the structure of the catalytic subunit of PKA, which proved to be a prototype for nearly all other protein kinases. Her structural analyses uncovered detailed insights into the mechanisms of ATP and peptide binding and phosphate transfer as well as the roles of autophosphorylation and open versus closed conformations. These studies were complemented by her structural analyses for the type 1α and type IIβ regulatory subunits of PKA, which revealed how cAMP is recognized by two tandem binding sites linked allosterically.

The Taylor group then solved the structures of PKA holoenzyme. This work showed how the regulatory subunit inhibits the catalytic subunit by forming an R2C2 holoenzyme complex where two regulatory subunits block the activity of each catalytic subunit. Sequential and allosteric binding of cAMP to the regulatory subunit initiates conformational changes that lead to the dissociation of the catalytic activity of the C-subunit, which can then bind its substrate. P. Boon Chock of the National Heart, Lung and Blood Institute states that this molecular switch is a fundamental regulator of many biological events and defines a mechanism that is adapted in different ways by protein kinases.

Next, the Taylor group began comparing kinases and found another unifying theme: the hydrophobic spine that is present in all active protein kinases. This feature has proven invaluable for inhibitor development. In addition, Taylor collaborated with the late Roger Tsien of UCSD to measure cAMP levels and PKA activity in living cells. From this, she discovered a nuclear export signal in the protein kinase inhibitor.

With the later discovery of proteins known as AKAPs and the mechanism of allosteric activation of the RAF kinase, the Taylor group solidified themselves as leaders in the field. “Her research provides fundamental breakthroughs in our understanding of the catalytic action and regulation of protein kinases,” states Chock.

The Stadtmans, for whom this award was named, exemplified scientific research, mentorship and science statesmanship. Mark A. Lemmon of the Yale University Cancer Biology Institute wrote in his letter of support for Taylor’s nomination, “Susan Taylor was a frequent visitor to the Stadtmans’ laboratories at (the National Institutes of Health), and indeed has described herself as ‘a surrogate member of Earl’s family.’”

Taylor received a bachelor’s degree in chemistry from the University of Wisconsin–Madison and a Ph.D. in physiological chemistry from the Johns Hopkins University. She then held two postdoctoral positions at the Medical Research Council Laboratory of Molecular Biology in the U.K. and UCSD.

Among other awards, Taylor has won the ASBMB William C. Rose Award, an American Association for the Advancement of Science fellowship and the Federation of American Societies for Experimental Biology Excellence in Science Award. She also served as president of the ASBMB.

She was elected into the National Academy of Sciences, the National Academy of Medicine, and the American Academy of Arts and Sciences and served on the fellowships advisory panel for the Packard Foundation and the General Motors Cancer Research Foundation Awards Assembly.

Enjoy reading ASBMB Today?

Become a member to receive the print edition monthly and the digital edition weekly.

Learn more
Dawn Hayward

Dawn Hayward earned a Ph.D. in biochemistry from the Johns Hopkins University School of Medicine

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in People

People highlights or most popular articles

ASBMB delegates leave their mark on policymaking
Feature

ASBMB delegates leave their mark on policymaking

Dec. 1, 2022

Advocacy Training Program participants use their new skills to improve their institutional environments, create new programs, draft policy recommendations, perform targeted outreach and more.

2022 Sewer scholarship winners announced
Society News

2022 Sewer scholarship winners announced

Nov. 28, 2022

The $2,000 award goes to undergraduates who demonstrate an interest in the fields of biochemistry and molecular biology and enhance the diversity of science.

Brought to you (mostly) by and for women
Annual Meeting

Brought to you (mostly) by and for women

Nov. 23, 2022

The ASBMB’s Women in Biochemistry and Molecular Biology Committee has big plans for Discover BMB 2023.

Dedicated to sharing science
Student Chapters

Dedicated to sharing science

Nov. 21, 2022

Introduced to scientific research through her Tufts University ASBMB Student Chapter, Lema Abuoqab works to make sure other students can have the same experience.

Tolbert named HHMI VP; new phase for Hannun
Member News

Tolbert named HHMI VP; new phase for Hannun

Nov. 21, 2022

Awards, promotions, milestones and more. Find out what's going on in the lives of ASBMB members.

What’s in the structural vaccine designer’s toolbox?
Interview

What’s in the structural vaccine designer’s toolbox?

Nov. 17, 2022

Structural biologist Jason McLellan, a researcher at UT Austin, has been recognized widely for his work on vaccine development. We asked him about the nuts and bolts of engineering the best antigen.