In Memoriam

In memoriam: Guido Guidotti

ASBMB Today Staff
Aug. 16, 2021

Guido Guidotti, a professor of biochemistry at Harvard University who studied the functions of proteins within membranes in transport and signal processing, died April 5 in Newton, Massachusetts. He was 87.

Guido Guidotti

Born Nov. 3, 1933, in Florence, Italy, Guidotti spent most of his early life in Naples. After World War II, he visited Illinois as an American Field Service student. He returned to do premedical studies at Milliken College, then earned an M.D. at the Washington University School of Medicine in St. Louis. He was an intern and resident at Barnes Hospital before earning a Ph.D. in biochemistry from Rockefeller University. He took a position at Harvard in 1963 and remained there until his death.

In his early research, Guidotti used his own blood to determine the sequence and biochemical properties of hemoglobin before moving on to the study of membrane proteins. He identified structures and topologies of numerous proteins and enzymes as well as studying hormone regulation of membrane protein activity. He discovered that the protein CD39, in the cell membrane, hydrolyzes extracellular adenosine triphosphate, ensuring that this extracellular ATP is present at an appropriate concentration.

A member of the American Society for Biochemistry and Molecular Biology since 1968, Guidotti served on the editorial board of the Journal of Biological Chemistry from 1971 to 1976 and published 120 papers in the JBC. He also served on the editorial boards of the Journal of Membrane Biology and Molecular Biology of the Cell.

Nancy Kleckner, Guidotti's wife and a Harvard colleague, wrote in a remembrance, “From the perspective of the outside world, Guido's scientific work was seminally important in many respects … Guido's research was motivated only by his intellectual curiosity, his delight in figuring out how life works, and his joy in enabling the work and lives of the people he trained and with whom he worked. Scientific credit was not a priority.”

Enjoy reading ASBMB Today?

Become a member to receive the print edition monthly and the digital edition weekly.

Learn more
ASBMB Today Staff

This article was written by a member or members of the ASBMB Today staff.

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in People

People highlights or most popular articles

Rossjohn named fellow; Decker joins science board; Gillaspy appointed dean
Member News

Rossjohn named fellow; Decker joins science board; Gillaspy appointed dean

Aug. 1, 2022

Awards, promotions, milestones and more. Find out what's going on in the lives of ASBMB members.

In memoriam: Mark Kester
In Memoriam

In memoriam: Mark Kester

Aug. 1, 2022

He was a cancer researcher and biochemist who was well known in the lipid and sphingolipid fields.

Always in a hurry
BMB in Africa

Always in a hurry

July 28, 2022

ASBMB member René Fuanta writes about his science education in the U.S and in Cameroon.

BMB stories from Africa
BMB in Africa

BMB stories from Africa

July 28, 2022

How the June/July issue of ASBMB Today came to be.

600 flavors of home
BMB in Africa

600 flavors of home

July 27, 2022

Former molecular biologist Tapiwa Guzha sells bespoke ice creams with a mission at a café in Cape Town.

A science journey from beer to TB
BMB in Africa

A science journey from beer to TB

July 26, 2022

ASBMB member Colin Kenyon researches drug target identification, enzyme reaction mechanisms and rational drug design for tuberculosis at Stellenbosch University.