Award

Jura is inspired by her grandmother,
a ‘true pioneer’

ASBMB Early-Career Leadership Award
Kerri Beth  Boggs
May 21, 2020

When she was a child, Natalia Jura traveled from Krakow to northern Poland to spend the summer months with her grandmother. Her grandmother was a pharmacist, and she gave Jura small tasks to help serve her customers. Jura learned how to weigh and mix chemicals for her grandmother’s formulations. She became curious about how the medicines worked.

Jura-Natalia-400x448.jpg
Natalia Jura

“I wondered, ‘How does she know what to mix so that people get better?’” Jura said.

Jura now considers her grandmother a true pioneer. After leaving university to have children, Jura’s grandmother returned to finish her degree and become a pharmacist. Her determination and ambition inspired Jura to take on new challenges.

“She would always tell me, ‘Your brain is your biggest asset,’” Jura said. “Growing up as a girl, that was an important message.”

Jura created a home laboratory. She tested acids and bases with pH indicators and observed the color changes. Her mind thrived on figuring out how things worked.

Jura’s scientific interests grew stronger throughout school, so she pursued a master’s in molecular biology from Jagiellonian University in Poland. Though the university had little funding, Jura’s professors carved out projects to give their students research experience. Jura learned that she could accomplish goals in science even when resources were sparse.

Jura earned her Ph.D. in molecular and cellular biology at Stony Brook University in New York. She then entered the world of structural biology as a postdoc at the University of California, Berkeley.

Now an associate professor at the University of California, San Francisco, Jura said she is grateful for the collaborations she has built since she started her lab in 2010.

“The ultimate beauty of science is when we team up and work together on something.”

Chasing structures of elusive cell receptors

Natalia Jura aims to understand how cells communicate with each other and the environment. Her lab addresses this question by studying the structure of single-pass transmembrane proteins, which serve as cell surface receptors. Receptor tyrosine kinases, or RTKs, represent leading clinical targets since they are often hijacked by cancers and viruses. The long-term goal of Jura’s lab is to develop therapeutic strategies to target these receptors in human diseases.

RTKs eluded structural investigation for many years because they are difficult to express and analyze via X-ray crystallography. Jura’s lab developed techniques to improve the purification of these receptors. They use cryo-electron microscopy to study different conformations of the proteins. One goal of Jura’s lab is to reconstruct the architecture of RTK signaling complexes to understand how they promote cell proliferation, division, movement and other crucial processes.

Jura’s lab also studies the molecular and structural mechanisms by which pseudokinases communicate signals. These highly conserved proteins evolved parallel to catalytic kinases, and they represent another important group of disease targets. Although pseudokinases are members of the protein kinase superfamily, they primarily utilize noncatalytic mechanisms for signaling. Jura hopes that understanding the structure and function of these proteins will open doors for development of inhibitors to target pseudokinases linked to disease.

ASBMB Early-Career Leadership Award

Natalia Jura is the inaugural recipient of the ASBMB Early-Career Leadership Award honoring an individual who is an associate professor, assistant professor or equivalent with a strong commitment to advancing the careers of women in biochemistry and molecular biology along with demonstrated excellence in research, discovery and/or service. Due to the cancellation of the 2020 ASBMB Annual Meeting, this award will be presented at the 2021 ASBMB Annual Meeting in Indianapolis.
Kerri Beth  Boggs

Kerri Beth Boggs is a graduate student in the biochemistry department at the University of Kentucky.

Join the ASBMB Today mailing list

Sign up to get updates on articles, interviews and events.

Latest in People

People highlights or most popular articles

Nautilus founder unspirals a new approach to proteomics
Feature

Nautilus founder unspirals a new approach to proteomics

Sept. 21, 2021

Parag Mallick may be trying to launch a competing proteomics technique, but you won’t catch him badmouthing mass spectrometers.

In memoriam: Stephen Prescott
In Memoriam

In memoriam: Stephen Prescott

Sept. 20, 2021

A former JBC associate editor and president of the Oklahoma Medical Research Foundation, he wrote about his journey with cancer.

In memoriam: Teruko Tamura
In Memoriam

In memoriam: Teruko Tamura

Sept. 20, 2021

Trained as a verterinarian, Tamura made major contributions to cancer research focusing on the Src and FMS-like tyrosine kinases and signal transduction, gaining a worldwide reputation in the field.

Finding the right research path
Interview

Finding the right research path

Sept. 16, 2021

Karen Bornfeldt, an associate editor for the Journal of Lipid Research, investigates how diabetes increases cardiovascular disease risk.

Society news briefs: September 2021
Society News

Society news briefs: September 2021

Sept. 14, 2021

Find out everything that’s been going on lately with the American Society of Biochemistry and Molecular Biology.

Doing policy work at scientific societies
Jobs

Doing policy work at scientific societies

Sept. 14, 2021

This is the second part in a series about scientists who've launched and established careers at nonprofit professional-development organizations.