Jura is inspired by her grandmother,
a ‘true pioneer’

ASBMB Early-Career Leadership Award
Kerri Beth  Boggs
May 21, 2020

When she was a child, Natalia Jura traveled from Krakow to northern Poland to spend the summer months with her grandmother. Her grandmother was a pharmacist, and she gave Jura small tasks to help serve her customers. Jura learned how to weigh and mix chemicals for her grandmother’s formulations. She became curious about how the medicines worked.

Natalia Jura

“I wondered, ‘How does she know what to mix so that people get better?’” Jura said.

Jura now considers her grandmother a true pioneer. After leaving university to have children, Jura’s grandmother returned to finish her degree and become a pharmacist. Her determination and ambition inspired Jura to take on new challenges.

“She would always tell me, ‘Your brain is your biggest asset,’” Jura said. “Growing up as a girl, that was an important message.”

Jura created a home laboratory. She tested acids and bases with pH indicators and observed the color changes. Her mind thrived on figuring out how things worked.

Jura’s scientific interests grew stronger throughout school, so she pursued a master’s in molecular biology from Jagiellonian University in Poland. Though the university had little funding, Jura’s professors carved out projects to give their students research experience. Jura learned that she could accomplish goals in science even when resources were sparse.

Jura earned her Ph.D. in molecular and cellular biology at Stony Brook University in New York. She then entered the world of structural biology as a postdoc at the University of California, Berkeley.

Now an associate professor at the University of California, San Francisco, Jura said she is grateful for the collaborations she has built since she started her lab in 2010.

“The ultimate beauty of science is when we team up and work together on something.”

Chasing structures of elusive cell receptors

Natalia Jura aims to understand how cells communicate with each other and the environment. Her lab addresses this question by studying the structure of single-pass transmembrane proteins, which serve as cell surface receptors. Receptor tyrosine kinases, or RTKs, represent leading clinical targets since they are often hijacked by cancers and viruses. The long-term goal of Jura’s lab is to develop therapeutic strategies to target these receptors in human diseases.

RTKs eluded structural investigation for many years because they are difficult to express and analyze via X-ray crystallography. Jura’s lab developed techniques to improve the purification of these receptors. They use cryo-electron microscopy to study different conformations of the proteins. One goal of Jura’s lab is to reconstruct the architecture of RTK signaling complexes to understand how they promote cell proliferation, division, movement and other crucial processes.

Jura’s lab also studies the molecular and structural mechanisms by which pseudokinases communicate signals. These highly conserved proteins evolved parallel to catalytic kinases, and they represent another important group of disease targets. Although pseudokinases are members of the protein kinase superfamily, they primarily utilize noncatalytic mechanisms for signaling. Jura hopes that understanding the structure and function of these proteins will open doors for development of inhibitors to target pseudokinases linked to disease.

ASBMB Early-Career Leadership Award

Natalia Jura is the inaugural recipient of the ASBMB Early-Career Leadership Award honoring an individual who is an associate professor, assistant professor or equivalent with a strong commitment to advancing the careers of women in biochemistry and molecular biology along with demonstrated excellence in research, discovery and/or service. Due to the cancellation of the 2020 ASBMB Annual Meeting, this award will be presented at the 2021 ASBMB Annual Meeting in Indianapolis.

Enjoy reading ASBMB Today?

Become a member to receive the print edition monthly and the digital edition weekly.

Learn more
Kerri Beth  Boggs

Kerri Beth Boggs is a graduate student in the biochemistry department at the University of Kentucky.

Related articles

COVID-19, preprints and journalists
Alice Fleerackers & Lauren A. Maggio
From the journals: MCP
Nivedita Uday Hegdekar
Fun in Seattle
Ann Stock

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in People

People highlights or most popular articles

ASBMB delegates leave their mark on policymaking

ASBMB delegates leave their mark on policymaking

Dec. 1, 2022

Advocacy Training Program participants use their new skills to improve their institutional environments, create new programs, draft policy recommendations, perform targeted outreach and more.

2022 Sewer scholarship winners announced
Society News

2022 Sewer scholarship winners announced

Nov. 28, 2022

The $2,000 award goes to undergraduates who demonstrate an interest in the fields of biochemistry and molecular biology and enhance the diversity of science.

Brought to you (mostly) by and for women
Annual Meeting

Brought to you (mostly) by and for women

Nov. 23, 2022

The ASBMB’s Women in Biochemistry and Molecular Biology Committee has big plans for Discover BMB 2023.

Dedicated to sharing science
Student Chapters

Dedicated to sharing science

Nov. 21, 2022

Introduced to scientific research through her Tufts University ASBMB Student Chapter, Lema Abuoqab works to make sure other students can have the same experience.

Tolbert named HHMI VP; new phase for Hannun
Member News

Tolbert named HHMI VP; new phase for Hannun

Nov. 21, 2022

Awards, promotions, milestones and more. Find out what's going on in the lives of ASBMB members.

What’s in the structural vaccine designer’s toolbox?

What’s in the structural vaccine designer’s toolbox?

Nov. 17, 2022

Structural biologist Jason McLellan, a researcher at UT Austin, has been recognized widely for his work on vaccine development. We asked him about the nuts and bolts of engineering the best antigen.