Award

Ferguson honored for important
translational research in parasitology

He won the ASBMB's Alice and C.C. Wang Award in Molecular Parasitology
Caitlin Hanlon
By Caitlin Hanlon
March 1, 2016

Michael A. J. Ferguson, associate dean for research strategy for the School of Life Sciences at the University of Dundee in Scotland, is the 2016 awardee of the American Society for Biochemistry and Molecular Biology's  Alice and C.C. Wang Award in Molecular Parasitology. Ferguson’s discovery of glycosyl-phosphatidyl inositol, or GPI, anchors revolutionized the membrane protein field and biochemistry itself. Ferguson then transitioned his expertise in GPI biosynthesis to the parasitology field and the development of therapeutics targeting the parasitic GPI pathway.

Ferguson-Mike-235x293.jpg
“This prize is of particular significance to me. Alice and C.C. Wang are outstanding pioneers of molecular parasitology. It is a terrific honour to be selected by a distinguished panel of peers for an award bearing the names of, and endowed by, Alice and C.C. Wang. I am also extremely grateful to my co-workers, past and present, for making this possible.” — Michael A. J. Ferguson

The Wang Award recognizes scientists who make significant contributions to the field of molecular parasitology. “Michael Ferguson’s achievements place him in this topmost rank of scientists,” wrote George Cross of The Rockefeller University in his letter of support for Ferguson’s nomination. “He is the world leader in a field that has significance throughout the entire domain of eukaryotic membrane biology … and will continue to make unique contributions to understanding pathogenic mechanisms in parasitic protozoa.”

Ferguson’s first major contribution to the field was identifying how a surface protein without any discernible transmembrane domains remains attached to the outside of a cell. The agents of human African trypanosomiasis use their variant surface glycoproteins, or VSGs, to evade a host’s immune system. As a postdoc in Cross’ lab at The Rockefeller University, Ferguson identified the fatty acid components that anchor the trypanosome’s VSG to the plasma membrane. Now known as GPI anchors, Ferguson’s discovery of this glycolipid post-translational modification catalyzed the field, and soon many other labs were building on his finding. Ferguson went on to deduce the structure of an entire GPI anchor. As Cross wrote, this work was seminal: “Descriptions of GPI anchors are now a standard component of most biochemistry, cell biology and immunology textbooks.” These findings laid the groundwork for the establishment of Ferguson’s own laboratory, which went on to determine the structure and pathways of many complex glycoconjugates and the pathways.

Many parasites have very unusual glyoconjugates. Ferguson recognized that this unique feature could be “an Achilles’ heel for antimicrobial chemotherapy,” wrote Professor Keith Gull at Oxford University in his letter of support for Ferguson's nomination of the award. By developing drugs that inhibit the enzymatic pathways that create these unique lipid anchors, Ferguson and his laboratory are able specifically to target the parasites that cause devastating illnesses such as malaria and trypanosomiasis.

To further his translational research, Ferguson and his colleagues, with financial support from the Wellcome Trust, established the groundbreaking Drug Discovery Unit at the University of Dundee. He also has led two major expansions of the Dundee College of Life Sciences, which is one of the top three biological research schools in the U.K.

Awarded the Royal Medal by the Royal Society of Edinburgh, Ferguson is a fellow of the Royal Society. He is also a Regius professor of life sciences, an honor bestowed by the monarch just twice in the past century, and recently was appointed to the governing body of the Wellcome Trust.

Ferguson earned his bachelor’s degree from the University of Manchester, and a Ph.D. in biochemistry at the University of London. After his postdoctoral studies at The Rockefeller University, he continued his work at the University of Oxford before starting his own lab at the University of Dundee.

Watch Ferguson’s award lecture, “Translating the trypanosome surface,” below.

Caitlin Hanlon
Caitlin Hanlon

Caitlin Hanlon earned a BS from Ursinus College and a Ph.D. from the Department of Cell Biology at the Johns Hopkins School of Medicine.

Related articles

Reimagining STEM workforce development as a braided river
Rebecca L. Batchelor, Hendratta Ali, Kathryn G. Gardner-Vandy, Anne U. Gold, Jennifer A. MacKinnon & Pranoti M. Asher

Join the ASBMB Today mailing list

Sign up to get updates on articles, interviews and events.

Latest in People

People highlights or most popular articles

Samuel H. Wilson Jr. (1939–2021)
In Memoriam

Samuel H. Wilson Jr. (1939–2021)

June 14, 2021

He made seminal contributions to the field of DNA repair and served for decades as a leader at the National Institutes of Health.

Academy elects new members
Member News

Academy elects new members

June 7, 2021

Of the 120 new members elected to the National Academy of Sciences, nine are ASBMB members.

Can people vaccinated against COVID-19 still spread the coronavirus?
News

Can people vaccinated against COVID-19 still spread the coronavirus?

June 6, 2021

Preliminary evidence seems to suggest that someone who’s vaccinated is less likely transmit the virus, but the proof is not yet ironclad.

How an interest in circuits led to a career in medical devices
Jobs

How an interest in circuits led to a career in medical devices

June 4, 2021

Our industry careers columnist spoke with Damini Agarwal of Infinite Biomedical Technologies.

Exploring underappreciated molecules and new cities
Interview

Exploring underappreciated molecules and new cities

June 2, 2021

Neurochemist Xianlin Han has been an associate editor for the Journal of Lipid Research since 2019.

Goldwater scholars announced
Member News

Goldwater scholars announced

May 31, 2021

The recipients of these scholarships are second- and third-year undergraduates from across the United States. Eight are ASBMB student members.