Disease discoveries in three realms of the RNA world
The RNA world is key to understanding gene expression in eukaryotes. This track will include three sessions describing exciting discoveries in RNA and disease: small noncoding RNAs, RNA modifications and RNA binding proteins.
The session on small noncoding RNAs will focus on discoveries in model systems and humans regarding transfer RNAs, tRNA fragments and Piwi-interacting RNAs regarding their biogenesis, functions, and roles in development and disease.
After transcription, nearly every type of RNA becomes decorated with nucleoside modifications; the RNA modification session will describe novel roles these modifications play in decoding, RNA stability and RNA regulation and activities. It also will describe how these modifications function in normal and aberrant biological states.
RNA functions rely on interactions with RNA binding proteins; the session on RNA binding proteins will describe how RNA-protein interactions regulate chromatin structure, transcription and splicing and how the interactions are involved in development and disease.
Keywords: small noncoding RNAs, RNA modification, RNA binding proteins, tRNA, piRNA, miRNA, tRNA fragments, gene expression, stem cells, muscle cells, development, cancer.
Who should attend: everyone who wants to learn how the RNA world impinges on gene expression in health and disease.
Theme song: “Hello, Goodbye” by the Beatles, because the song reminds us of the life of RNAs in a cell.
This track is powered by different kinds of RNAs — obviously.
Talks
- tRNA: Splicing and subcellular dynamics — Anita Hopper, Ohio State University
- The role of 3’tsRNAs in gene regulation — Mark Kay, Stanford University
- The Piwi-piRNA pathway: A new paradigm in gene regulation — Haifan Lin, Yale University
- piRNA biogenesis and function in Drosophila — Mikiko Siomi, University of Tokyo
- RNA modification in cancer — Jianjun Chen, Beckman Research Institute of City of Hope
- RNA modifications in health and disease — Tsutomu Suzuki, University of Tokyo
- Acetylation of cytidine in messenger RNA regulates translation — Shalini Oberdoerffer, National Cancer Institute
- tRNA quality control: Mechanisms, evolution, and implications for human disease — Eric Phizicky,University of Rochester Medical Center
- RNA binding proteins in stem cells and cancer — Takahiro Ito, University of Georgia
- The RNA exosome and genetic disease — Anita Corbett, Emory University
- RNA, chromatin, and the coordinated control of gene expression — Tracy Johnson, University of California, Los Angeles
- How mRNP composition determines mRNA fate — Guramrit Singh, Ohio State University
Enjoy reading ASBMB Today?
Become a member to receive the print edition four times a year and the digital edition weekly.
Learn moreFeatured jobs
from the ASBMB career center
Get the latest from ASBMB Today
Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.
Latest in Careers
Careers highlights or most popular articles
Upcoming opportunities
Register for the 2025 ASBMB Annual Meeting in Chicago by Feb. 18 to save on costs!
Facing the challenges of an M.D./Ph.D.
Grad school and med school are very different in their structures and priorities. So what’s the best strategy for doing both at the same time?
Upcoming opportunities
Save the date for ASBMB's meeting on transforming undergraduate education! Reminder: Submit your #ASBMB25 abstract by Dec. 9.
Upcoming opportunities
Friendly reminder: Book a recruiter table at ASBMB's career and education fair by Nov. 30 to secure early-bird pricing! Just added: Applications are being accepted for a post-bac at Dartmouth Cancer Center.
Upcoming opportunities
Just added: Register for ASBMB's virtual session on thriving in challenging academic or work environments.
Who decides when a grad student graduates?
Ph.D. programs often don’t have a set timeline. Students continue with their research until their thesis is done, which is where variability comes into play.