Annual Meeting

Outside-in biology and disease

Glycosylation and extracellular matrix in development and disease: 2020 annual meeting track
Jamey David Marth Joanne Murphy–Ullrich
By Jamey David Marth and Joanne Murphy–Ullrich
Sept. 1, 2019

For life to exist, cells need to be able to sense and respond to their environment. To do so, cells of multicellular organisms produce highly specialized networks of proteins and glycans that include the extracellular matrix, or ECM. Glycans and ECM both provide and recognize extracellular signals and translate them into biological information. In turn, cells alter their phenotype in this bidirectional life process, which combines intrinsic template-dependent biology (nucleic acids and proteins) with template-independent metabolism (glycans and lipids). Glycosylation and the ECM are critical features of this bidirectional control of cell biology and disease. Glycans, produced by the enzymatic process of glycosylation, are an abundant and diverse repertoire of glycosidic linkages. The ECM is a complex network of secreted glycoproteins, proteoglycans and glycosaminoglycans that interact with cell receptors, ECM molecules, growth factors and enzymes.

This track will explore the activities and mechanisms by which these cell-derived components govern health and disease, emphasizing emerging links with cancer, immunity, inflammation and metabolism and including infectious and neurological diseases.

Keywords: glycosylation, ECM, cancer, inflammation, development, fibrosis, immunity, infection, neurobiology

Who should attend: anyone who is interested in understanding how cells function and respond to the environment through componentry that includes glycans and the ECM in the regulation of development, metabolism, inflammation and immunity and in the pathogenesis of multiple diseases

Theme song: “Built to Last” by the Grateful Dead.

This track is powered by proteins and sugars.

Talks

  • Role of O-linked fucose-glucose disaccharide modification of thrombospondin type I repeats during protein folding and embryo development — Bernadette Holdener, Stony Brook University
  • Fibrillin-Notch interactions in development and disease — Lynn Sakai, Oregon Health & Science University
  • A genetic approach to glycomics in cancer — Henrik Clausen, University of Copenhagen
  • TGF-beta regulation by the matricellular protein thrombospondin 1 — Joanne Murphy–Ullrich, University of Alabama at Birmingham
  • Quieting mast cells for treatment of allergies — James Paulson, Scripps Research
  • Decoding inflammatory signals from ECM glycans for the development of new immunotherapies — Kim Midwood, University of Oxford
  • Glycosylation in a common pathogenic mechanism of colitis and sepsis — Jamey Marth, University of California, Santa Barbara and the SBP Discovery Discovery Institute, LaJolla
  • Genomewide analysis of heparan sulfate assembly — Jeffrey Esko, University of California, San Diego
  • Protective roles of O-GlcNAc in neurodegenerative diseases — David Vocadlo, Simon Frasier University
  • The role of the O-GlcNAc transferase interactome in X-linked intellectual disability — Lance Wells, University of Georgia
  • Role of ECM in the brain-gut connection — Fernando Gomez-Pinilla, University of California, Los Angeles
  • The role of metabolism in modulating radiation fibrosis — Fei-Fei Liu, Princess Margaret Cancer Centre, Toronto

Enjoy reading ASBMB Today?

Become a member to receive the print edition monthly and the digital edition weekly.

Learn more
Jamey David Marth
Jamey David Marth

Jamey David Marth is director of the center for nanomedicine, Carbon professor of biochemistry and molecular biology, and Mellichamp professor of systems biology at the University of California, Santa Barbara and the Sanford Burnham Prebys Medical Discovery Institute in La Jolla.

Joanne Murphy–Ullrich
Joanne Murphy–Ullrich

Joanne Murphy–Ullrich is a professor of pathology, ophthalmology, and cell developmental and integrative biology at the University of Alabama at Birmingham.

Featured jobs

from the ASBMB career center

Get the latest from ASBMB Today

Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.

Latest in Careers

Careers highlights or most popular articles

Calendar of events, awards and opportunities
Announcement

Calendar of events, awards and opportunities

Jan. 23, 2022

Just added: Free ASBMB webinar for educators on creating inclusive classrooms and free FASEB conference on soil and water quality.

What is it like to work at the EPA?
Jobs

What is it like to work at the EPA?

Jan. 22, 2022

Muna Nahar has worked as a toxicologist at the EPA through three presidencies.

Severe staffing shortages in medical laboratories
Jobs

Severe staffing shortages in medical laboratories

Jan. 22, 2022

The omicron variant of COVID-19 is making the problem worse across the U.S.

Pubs workshop to cover images, words and reach
Annual Meeting

Pubs workshop to cover images, words and reach

Jan. 19, 2022

At the ASBMB Annual meeting, experts will offer insights into the publication pipeline and provide tips on presenting data, writing well and sharing.

Career-development programming at the annual meeting
Annual Meeting

Career-development programming at the annual meeting

Jan. 18, 2022

The 2022 ASBMB Annual Meeting in April offers a collection of programming to meet a variety of needs for members of all career stages and interests.

Tips for mentors headed to the undergrad poster competition
Annual Meeting

Tips for mentors headed to the undergrad poster competition

Jan. 17, 2022

Here is some advice to build your confidence and help you set up your students for success at this special event at the ASBMB annual meeting.