Postdoc wins Tabor award for lipid membrane research
Lipid membranes surround and protect each of our cells. They serve as a first line of defense, allow for intracellular signaling and keep subcellular compartments separate. The lipid composition must therefore be diverse and distinctive enough to keep a cell running smoothly. Figuring out which lipids are needed where and when can be challenging, however. Itay Budin, a postdoctoral fellow at the University of California, Berkeley, studies lipid properties and why certain ones belong in specific cell membranes. For his research, Budin received a 2017 Journal of Biological Chemistry/Herbert Tabor Young Investigator Award.
![](http://www.asbmb.org/imagearchive/75773/Itay-Budin-web.jpg)
Budin investigates how lipid composition affects membrane properties and the consequences of altering particular lipids in model organisms. Lipids make up cellular and subcellular membranes and help maintain integrity and compartmentalization. However, manipulation of these lipids to understand their roles has been done primarily in vitro, and tools to recapitulate findings within living organisms are difficult to develop. Budin uses metabolic engineering to explore lipid composition and functionality. He explained that he does this by altering the genes that give rise to particular lipids. He is then able to “rewire” these pathways within the organism to understand which lipids are necessary for a particular membrane and why. Budin and colleagues have learned that a cell’s membrane can act as an environmental sensor, and a particular set of proteins then responds to maintain homeostasis. This work was published in May 2017 in the journal Metabolic Engineering.
JBC Associate Editor Dennis Voelker presented the award to Budin in August at the 2017 Gordon Research Conference on Molecular and Cell Biology of Lipids. Receiving the award was a “great honor and real thrill,” Budin said, and receiving it from Voelker, a lipid biologist, reinforced the importance of his work. The award committee thought Budin’s work was instrumental in “assigning a crucial mechanistic role for unsaturated lipids in serving as molecular signals that liberate transcription factors from the endoplasmic reticulum in response to a variety of stimuli,” they wrote with input from Voelker.
Budin earned his Ph.D. in biochemistry and physical biology from Harvard University in the laboratory of Jack W. Szostak investigating the changes in lipid composition throughout evolution. He then came to the University of California, Berkeley, on a Miller Institute Junior Fellowship. He works with Jay Keasling at the Joint BioEnergy Institute, a research center in Berkeley focused on synthetic biology and metabolic engineering.
Enjoy reading ASBMB Today?
Become a member to receive the print edition monthly and the digital edition weekly.
Learn moreGet the latest from ASBMB Today
Enter your email address, and we’ll send you a weekly email with recent articles, interviews and more.
Latest in People
People highlights or most popular articles
![Making cancer fight itself: The promise of PROTACs](/getmedia/dc084a9c-e9af-4508-9e73-2811cd8b0ad1/Zhang-thumb.jpg?width=480&height=270&ext=.jpg)
Making cancer fight itself: The promise of PROTACs
Jianchao Zhang received a JBC/Tabor award for his paper about designing a proteolysis-targeting chimera that inhibited tumor growth.
![The visa voyage](/getattachment/3c24e64f-1d8f-41ac-a081-9b9aead13daa/Immigrant-scientist-thumb-490-x-270-px.jpg?lang=en-US&width=490&height=270&ext=.jpg)
The visa voyage
International scientists fight through red tape and regulations for a chance to train and work in the U.S.
![AAAS names fellows](/getmedia/e8a15fdf-dc92-44c8-af30-cc33f22bfb7a/AAAS-fellows-thumb.jpg?width=480&height=270&ext=.jpg)
AAAS names fellows
Sixteen ASBMB members are among the scientists honored by the American Association for the Advancement of Science.
![The best of both worlds](/getmedia/6f48cc06-0c78-488d-8cb8-3efbd3d9df9d/Warner-thumb.jpg?width=480&height=270&ext=.jpg)
The best of both worlds
Blake Warner is chief of the Salivary Disorders Unit and the Sjögren's disease clinic at the NIH.
![In memoriam: Maxine Singer](/getmedia/32d42ded-d7d7-4503-93f4-e921a4245b0c/Maxine-Singer-thumb.jpg?width=480&height=270&ext=.jpg)
In memoriam: Maxine Singer
She was a revolutionary molecular biologist, National Medal of Science recipient, federal health official and inclusion advocate.
!['Challenging membrane' researcher wins Tabor award](/getmedia/4bc987cc-63e2-4703-a2f2-80de5b9a6fcf/Tabor-award-Kondolf-480x270.jpg?width=480&height=270&ext=.jpg)
'Challenging membrane' researcher wins Tabor award
Hannah Kondolf and her colleagues developed a system that activates gasdermin proteins in an efficient and equivalent manner and showed differences in two gasdermins.