Retrospective

Richard J. Havel (1925 – 2016)

ASBMB Today Staff
By ASBMB Today Staff
Aug. 1, 2016

Richard “Dick” J. Havel, former director of the Cardiovascular Research Institute at the University of California, San Francisco, died in April in Greenbrae, Calif. He was 91.

Havel contributed to the emergence of the field of lipid metabolism both as an institute director and head of the Specialized Center for Research in Arteriosclerosis, a National Institutes of Health-supported group of laboratories that brought an array of technical approaches to lipid research.

Richard J. Havel

Born in Seattle, Wash., Havel attended Reed College and went on to obtain his M.S. and M.D. from the University of Oregon Medical School in 1949. He completed his residency in medicine at Cornell University, serving as chief resident from 1952 to 1953. He then worked at the National Institutes of Health until 1956 before moving to UCSF to join the founding faculty of the Cardiovascular Research Institute.

While at the NIH, Havel developed the technique of quantitative ultracentrifugation, which remains a standard technique in the field to this day. It allowed the discrimination of clinical phenotypes and provided a basis for understanding lipid transport in health and disease. As a result of this work, Havel became the first to define the genetic disorder of lipoprotein lipase deficiency.

Havel succeeded Julius Comroe as director of the Cardiovascular Research Institute and later become interim director until his retirement in 1996. From 1971 until 1996, he also served as director of the NIH’s Specialized Center for Research in Arteriosclerosis, or SCOR.

Under his direction, SCOR investigators created a large body of integrated discovery on lipoprotein biology and its clinical significance, including the multistaged formation of triglyceride-rich lipoproteins, cholesterol efflux, structural and functional studies of HDL, and one of the first demonstrations that reducing the levels of atherogenic lipoproteins would result in diminution of the volume of arterial plaques.

Havel was elected to the National Academy of Sciences in 1983 and the Institute of Medicine in 1989. He won the Bristol Myers Squibb/Mead Johnson Award for Distinguished Achievement in Nutrition Research and a Distinguished Achievement Award from the American Heart Association Council on Arteriosclerosis. He served as editor-in-chief of the Journal of Lipid Research from 1972 to 1975 and as chair of its advisory board from 1982 to 1992.

Part of Havel’s legacy will be the careers of a large number of investigators who trained in his laboratory and with the SCOR group, who are now distinguished academicians in many countries. Havel leaves behind his wife, four children and three grandchildren.

This is a condensed version of an obituary that first appeared in the Journal of Lipid Research. It was written by John P. Kane and Mary J. Malloy at the University of California, San Francisco.

ASBMB Today Staff
ASBMB Today Staff

This article was written by a member or members of the ASBMB Today staff.

Related articles

Robert L. Post (1920 – 2021)
Jack H. Kaplan, Paul J. DeWeer & Joseph F. Hoffman
Herbert Tabor 1918 – 2020
F. Peter Guengerich
Sydney Brenner (1927 – 2019)
Terrence Sejnowski
Roberta F. Colman (1938 – 2019)
Harold B. White & Judith G. Voet

Join the ASBMB Today mailing list

Sign up to get updates on articles, interviews and events.

Latest in People

People highlights or most popular articles

Part 1: ‘Aha moments’ essay contest honorable mentions
Contest

Part 1: ‘Aha moments’ essay contest honorable mentions

May 6, 2021

To celebrate our three journals going open access, we invited readers to share their moments of discovery in science. Here are two honorable mentions.

Share your aha moments!
Editor's Note

Share your aha moments!

May 4, 2021

How a brainstorming session produced two videos, an essay contest and gratitude.

Winners of the ‘aha moments’ essay contest
Contest

Winners of the ‘aha moments’ essay contest

May 4, 2021

To celebrate our three journals going open access, we invited readers to share their moments of discovery in science. Here are the first, second and third place winners.

Stoddard wins mentoring award; Do honored as scholar–athlete
Member News

Stoddard wins mentoring award; Do honored as scholar–athlete

May 3, 2021

Awards, promotions, milestones and more. Find out what's going on in the lives of ASBMB members.

ASBMB welcomes new members
Member News

ASBMB welcomes new members

May 3, 2021

The American Society for Biochemistry and Molecular Biology welcomed more than 340 new members in January.

The 17th-century cloth merchant who discovered the vast realm of tiny microbes
News

The 17th-century cloth merchant who discovered the vast realm of tiny microbes

May 2, 2021

Although untrained in science, Antonie van Leeuwenhoek became the greatest lens-maker of his day, discovered microscopic life forms and is known today as the “father of microbiology.”