ASBMB Annual Meeting virtual posters

Though the 2020 ASBMB Annual Meeting has been canceled, we can still come together virtually to share our research.

Those who were programmed for a poster presentation at the 2020 ASBMB Annual Meeting can participate in the ASBMB's virtual poster presentations on YouTube.

Record a video of you presenting your research, upload it to YouTube and then submit your virtual poster presentation to us.

2020 Annual Meeting

The 2020 ASBMB Annual Meeting is canceled

After thoughtful deliberations, the leaders of the Experimental Biology host societies have made the difficult but necessary decision to cancel Experimental Biology (EB) 2020 set to take place April 4–7 in San Diego, California. We know how much EB means to everyone, and we did not make this decision in haste. The health and safety of our members, attendees, their students, our staff, partners and our communities are our top priority.

As we have previously communicated via email, on experimentalbiology.org and elsewhere, EB leadership has been closely monitoring the spread of COVID-19 (coronavirus disease). Based on the latest guidance from public health officials, the travel bans implemented by different institutions and the state of emergency declared in California less than 48 hours ago, it became clear to us that canceling was the right course of action.

We thank you and the entire EB community for understanding the extreme difficulty of this decision and for your commitment to the success of this conference — from the thousands of attendees to the presenters, exhibitors and sponsors who shared their time, expertise, collaboration and leadership. We deeply appreciate your contributions to this community.

What happens next?

Everyone who has registered to attend the meeting will receive a full registration refund within the next 45 days. Once your registration cancellation is processed, you will receive confirmation in a separate email. You do not need to contact anyone at EB or your host society to initiate the process. Despite the cancellation of the meeting, we are pleased to tell you that we will publish abstracts in the April 2020 issue of the FASEB Journal as originally planned. Please remember to cancel any personal arrangements you’ve made, such as travel and housing reservations.

We ask for patience as we evaluate our next steps, and we will alert you as additional information becomes available.

Learn more

Registration

Registration Type Early Registration
(on/before Feb. 5)
Advance Registration
(on/before Mar. 13)
Full-Price Registration
(Mar. 14–Apr. 7)
Members Nonmembers Members Nonmembers Members Nonmembers
Regular $430 $630 $570 $760 $595 $785
Retired $150 $185 $170 $205 $195 $230
Graduate student $95 $135 $105 $145 $130 $170
Undergraduate student $25 $40 $35 $50 $50 $60
Postdoctoral trainee $335 $435 $435 $535 $460 $560
One-day $285 $385 $295 $385 $310 $410
High school students and teachers Free

Program schedule

Please note that the meeting has been canceled.

Saturday April 4
Sunday April 5
Monday April 6
Tuesday April 7

Saturday agenda

8:50 AM - 4:25 PM

2020 Travel Awardee career development program

Open to selected travel awardees only

11:30 AM - 5:45 PM

Undergraduate student research poster competition events

Open to selected candidates only

11:30 a.m. – 12:30 p.m.
ASBMB Annual Meeting orientation for undergraduate students

11:30 a.m. – 6:00 p.m.
ASBMB undergraduate poster competition judges' orientation

1–4:30 p.m.
ASBMB undergraduate student research poster competition

4:45–5:45 p.m.
ASBMB undergraduate student research workshop: Exploring careers speed networking

1:00 PM - 5:00 PM

ASBMB Lab Management Course

Are you a new faculty member or PI? Are you a postdoctoral fellow or senior graduate student that is interested in starting your own lab? How do you go about setting up your lab? How will you manage an initial budget to get off to a great start? Who will you hire? What criteria will you use to select your staff and how will you mentor your trainees successfully? Will you be able to communicate effectively with your staff, and how will you handle any conflicts when they arise? If you have considered any of these questions, then sign up for this free interactive session. 

5:00 PM - 6:00 PM

CREST pre-conversations: Connecting researchers, educators and students

Organized by the MSOE Center for BioMolecular Modeling

Undergraduate CREST (Connecting Researchers, Educators and Students) teams will meet to discuss their shared research interests. This year teams have explored the research of Dr. Celia Schiffer, focusing on designing antiviral drugs that avoid resistance.

6:00 PM - 7:00 PM

Tang Prize award lecture

Tyrosine phosphorylation — From discovery to drug development and beyond
Tony Hunter, Salk Institute for Biological Studies
7:00 PM - 8:30 PM

EB welcome reception

Including:

EB Scientific Highlights
Highlighting 50 of the over 6,000 scientific posters to be presented later in the conference.

EB Scientific Outreach Activity Poster Session
Science outreach programs from around the country will have their activities on display which are certain to spark interest, ideas, networks and great conversation.

Sunday agenda

8:00 AM - 8:15 AM

ASBMB business meeting

8:15 AM - 8:45 AM

Herbert Tabor Research Award lecture

Structural basis of dystroglycan function and the pathogenesis of muscular dystrophy
Kevin Campbell, University of Iowa
8:30 AM - 11:30 AM

Mirage or metabolic crossroads? Metabolomics as a primary tool for hypothesis generation

Organized by the Society for Experimental Biology and Medicine
David Boothman, IU Simon Comprehensive Cancer Center Chair
8:45 AM - 9:15 AM

ASBMB–Merck Award lecture

Cellular machineries devoted to rubisco — the most abundant enzyme
Manajit Hayer-Hartl, Max Planck Institute of Biochemistry
9:15 AM - 11:15 AM

Molecular machines: New paradigms in structure, function and engineering

Chair: Stefanie Redemann, University of Virginia

Activation of the exocyst tethering complex for SNARE complex regulation and membrane fusion
Mary Munson, University of Massachusetts Medical School
Sugary coats: Synthesis and secretion of extracellular polysaccharides
Jochen Zimmer, University of Virginia School of Medicine
The ESCRT membrane scission machine
James Hurley, University of California, Berkeley
HiFi molecular transmission via crisscross cooperativity
William Shih, Harvard University
9:30 AM - 11:30 AM

Novel roles of lipids in health and disease

Chair: Steven Claypool, Johns Hopkins School of Medicine

BSCL2/Seipin in lipid catabolism and lipodystrophy
Weiqin Chen, Medical College of Georgia at Augusta University
The role of organelle contact during chlamydia developmental cycle
Isabelle Derré, University of Virginia
Tissue-specific roles of cardiolipin in the control of systemic energy homeostasis
Zachary Gerhart-Hines, University of Copenhagen
SPTLC1 mutations associated with early onset amyotrophic lateral sclerosis
Teresa Dunn, Uniformed Services University
9:30 AM - 11:30 AM

Glycosylation and extracellular matrix in development, repair and cancer

TGF-beta regulation by the matricellular protein thrombospondin 1
Joanne Murphy-Ullrich, University of Alabama at Birmingham Chair
Role of O-linked fucose-glucose disaccharide modification of thrombospondin type I repeats during protein folding and embryo development
Bernadette Holdener, Stony Brook University
Fibrillin-notch interactions in development and disease
Lynn Sakai, Oregon Health and Science University
A genetic approach to glycomics in cancer
Henrik Clausen, University of Copenhagen
9:30 AM - 11:30 AM

Mechanosignaling

Piezo1 activation gains traction
Medha Pathak, University of California, Irvine
Mechanotransduction through integrin-mediated adhesions
Martin Schwartz, Yale University
Mechanical force and notch signaling
Wendy Gordon, University of Minnesota Chair
Mechanisms linking mechanotransduction and cell metabolism
Kris DeMali, University of Iowa
9:30 AM - 11:30 AM

NAD synthesis, salvage and sirtuins in tissue healh

Chair: Anne Murphy, Cytokinetics, Inc.

A conserved role of CBP/p300 in mitochondrial stress response and longevity
Johan Auwerx, Ecole Polytechnique Fédérale de Lausanne
Mitochondrial NAD transport
Joseph A. Baur, University of Pennsylvania
Chromatin regulation and genome maintenance by mammalian SIRT6 and SIRT7
Katrin F. Chua, Stanford University and VA Palo Alto Health Care System
Metabolic competition in the tumor microenvironment
Marcia Haigis, Harvard Medical School
9:30 AM - 11:30 AM

Noncoding RNAs and disease

tRNA: Splicing and intron turnover
Anita Hopper, Ohio State University Chair
The role of tRNA derived small RNAs in gene regulation in normal tissues and cancer
Mark Kay, Stanford University
The Piwi-piRNA pathway: A new paradigm in gene regulation
Haifan Lin, Yale University
piRNA biogenesis and function in drosophila
Mikiko Siomi, University of Tokyo
9:30 AM - 11:30 AM

Who we are: Creating a culture of wellness in science

Chair: Daniel Dries, Juniata College

Preventing and overcoming harassment
Alex Helman, National Academies of Sciences, Engineering and Medicine
Promoting STEM identity: A vision for building tomorrow’s STEM leaders
Sarah Rodriguez, Texas A&M University – Commerce
Promoting mental well-being
Nathan Vanderford, University of Kentucky
Mentorship best practices
Joanne Kamens, Addgene
9:30 AM - 11:30 AM

Cell decision making

Lifelong analysis of key aging genes as determinants of lifespan in C. elegans
Adriana San Miguel, North Carolina State University
Nuclear mechanics in migrating cells
Tanmay Lele, University of Florida Chair
Clocks, hourglasses and history-dependent clocks
Arvind Murugan, University of Chicago
10:30 AM - 11:00 AM

Sci Comm by the Bumbling Biochemist

Micro-learning Hub
Bri Bibel, Watson School of Biological Sciences
11:45 AM - 1:00 PM

Meet the speakers

12:15 PM - 1:45 PM

ASBMB advocacy town hall meeting

Increasingly, policies developed and enacted in Washington are having an impact on how your science is funded, how your grants are reviewed and how reliable the future workforce of the research community will be. Serving the ASBMB membership proudly, the Public Affairs Advisory Committee and Office of Public Affairs regularly engages on your behalf with the Administration, the Congress and the individual funding agencies.

This Advocacy Town Hall is an opportunity to share your stories, and to tell the PAAC what policy areas you want to see the ASBMB taking a leadership role in. Hosted by Public Affairs Director Benjamin Corb, and PAAC Chair Terri Kinzy, the Advocacy Town Hall will allow you to engage in a conversation with our policy leaders, to hear about the critical policy issues facing the community, and ask questions.

12:30 PM - 1:00 PM

A word of advice: Crafting compelling article titles

Micro-learning Hub
Catherine Goodman, ASBMB
12:45 PM - 2:00 PM

Poster sessions

1:05 PM - 3:00 PM

Recent Developments and Implementation of Nanobodies

Organized by the Society for Experimental Biology and Medicine
1:30 PM - 3:00 PM

Changing research practice: How can I make my research more reproducible?

Co-sponsored by the American Physiological Society

This session will focus on concrete steps that biomedical researchers can take to implement more reproducible research practices in their laboratories. These include using RRIDs to identify key reagents, creating and sharing reproducible protocols that can be used by others, and using guidelines to enhance experimental rigor and improve reporting. Attendees will learn to recognize and fix common errors in data visualization and statistical reporting. Presenters will highlight tools and resources designed to assist researchers in implementing better practices. After attending the symposium, researchers should have a clear understanding of steps that they can immediately take to improve transparency and rigor in their next grant, research project, or paper.

2:15 PM - 2:45 PM

Earl and Thressa Stadtman Young Scholar Award lecture

Wiring the powerhouse: Systems-to-structure approaches for defining mitochondrial protein function
David Pagliarini, Morgridge Institute for Research
2:45 PM - 3:15 PM

Avanti Award in Lipids lecture

Death by lipids: Role of non-coding RNAs in metabolic stress
Jean Schaffer, Joslin Diabetes Center at Harvard University
3:00 PM - 4:00 PM

Award for Exemplary Contributions to Education lecture

A revolution in biochemistry education informed by basic research to meet the demands of 21st century career paths
Paul Black, University of Nebraska–Lincoln
3:00 PM - 5:00 PM

Proliferation and protection: Harnessing the beta-cell for novel diabetes therapies

Organized by the Society for Experimental Biology and Medicine

Chair: Rachel Fenske, University of Wisconsin-Madison

Dawn B. Davis, University of Wisconsin
Anath Shalev, University of Alabama–Birmingham
Debbie Thurmond, Beckman Research Institute of City of Hope
3:15 PM - 4:30 PM

JBC Herbert Tabor Early Career Investigator Awards

The Journal of Biological Chemistry honors first authors

Chair: George DeMartino, University of Texas Southwestern Medical Center

A low-potential terminal oxidase associated with the iron-only nitrogenase from the nitrogen-fixing bacterium Azotobacter vinelandii
Febin Varghese, Imperial College London
De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium
Kirstine Lavrsen, University of Copenhagen
Phosphorylation of HSP90 by protein kinase A is essential for the nuclear translocation of androgen receptor
Manisha Dagar, Amity Institute of Biotechnology
Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations
Wenchao Zhao, University of Bonn
Dihydronicotinamide riboside is a potent NAD+ concentration enhancer in vitro and in vivo
Yue Yang, Weill Cornell Medicine
3:30 PM - 5:30 PM

Regulation of protein function by shape shifting

Delano Award for Computational Biosciences lecture
Towards the solution of the protein structure prediction problem
Yang Zhang, University of Michigan
Multimeric proteins that can come apart, change shape, and reassemble differently with functional consequences — morpheeins
Eileen Jaffe, Fox Chase Cancer Center Chair
Moonlighting proteins where changing shape promotes changing function
Constance Jeffery, University of Illinois at Chicago
Filament formation induces a shape change and activation of the nuclease SgrAI
Nancy Horton, University of Arizona
Fold-switching sets the stage for cooperativity and competition in the cyanobacterial circadian clock
Carrie Partch, University of California, Santa Cruz
Dynamic oligomerization in burkholderia cenocepacia HMG-CoA reductase
Jeff Watson, Gonzaga University
Amino acid substitution at Phe80 of mammalian phenylalanine hydroxylase destabilizes both resting-state and activated conformations increasing the population of intermediates
Emilia Arturo, La Jolla Institute for Immunology
3:30 PM - 4:30 PM

Chromatin, structure and transcription

Glucocorticoids ameliorate arthritis through epigenetic regulation of CCL17 production
Adrian Achuthan, University of Melbourne Chair
Role of nuclear receptor condensates in ligand induced co-operative gene regulation
Sreejith Nair, University of California San Diego
Cryo-EM structure of CtBP2 confirms tetrameric architecture
Anne Jecrois, University of Massachusetts Medical School
Activation of ALC1 (CHD1L) nucleosome remodeling by PARP1-dependent poly(ADP-ribosyl)ation
Soon-Keat Ooi, Stowers Institute for Medical Research
3:30 PM - 4:30 PM

Emerging signaling pathways

Crosstalk between mTOR and estrogen signaling
Marina Holz, New York Medical College Chair
WNT receptor requirements for dishevelled phosphorylation
Katie Hollis, Van Andel Institute
A structural framework for the G protein selectivity of muscarinic acetylcholine GPCRs
Ravinder Abrol, California State University, Northridge
Uncovering the unique functions and regulation of the palmitoylated calcineurin isoform, CNβ1
Idil Ulengin-Talkish, Stanford University
3:30 PM - 4:30 PM

Glycosylation and extracellular matrix in development, repair and cancer

Pax2a regulates endothelial cell invasion into the optic fissure resulting in degradation of the basement membrane by mmp2
Megan Weaver, University of Kentucky
Reductions in complex and hybrid N-glycosylation are sufficient to cause dilated cardiomyopathy that deteriorates into heart failure through acute and chronic mechanisms
Eric Bennett, Wright State University
How do O-fucose glycans stabilize thrombospondin type 1 repeats?
Steven Berardinelli, University of Georgia Chair
Molecular interaction of neuropilin-1 and 3-O-sulfated heparan sulfate modulates angiogenesis-dependent tumor growth
Chelsea Painter, University of California, San Diego
3:30 PM - 4:30 PM

Lipids and eicosanoid signaling

L-lactate dehydrogenase A selectively interacts with phosphatidic acid species containing stearic acid at the sn-1 position
Fumi Hoshino, Chiba University
Functional relationship between sphingomyelin synthase-related protein and diacylglycerol kinase δ
Chiaki Murakami, Chiba University
Unique substrate specificity of human phospholipase A2s
Daiki Hayashi, University of California, San Diego Chair
The study of sphingolipids metabolism and its effect on brain disorders
Ricardo Hernandez, Presbyterian College
3:30 PM - 4:30 PM

Lipids and membranes

Membrane phospholipid composition governs Pah1 phosphatidate phosphatase activity
Joanna Kwiatek, Rutgers University Chair
Rapid formation of ER-PM contacts during early stages of phagocytosis
Minhyoung Lee, University of Toronto
Unique aspects of lipid metabolism in the human gut microbiome
Christopher Radka, St. Jude Children's Research Hospital
Development and application of a new platform for measuring phospholipase A2 activity in cells using mass spectrometry
Joseph Argus, University of California, San Diego
3:30 PM - 4:30 PM

New insights into fatty acid biology

Human keratinocytes synthesize ultra long-chain sphingoid bases (up to C28) that are abundant in skin stratum corneum
Evgeny Berdyshev, National Jewish Health
Role of AIG1 and ADTRP in endogenous FAHFA regulation
Meric Erikci Ertunc, Salk Institute for Biological Studies
The dynamic proteome and lipidome of plastoglobule lipid droplets of plant plastids
Peter Lundquist, Michigan State University Chair
Saturated fatty acid-enriched diet exacerbate hepatic mitochondrial dysfunction in rats subjected to maternal protein restriction
Aiany Simões-Alves, Federal University of Pernambuco
3:30 PM - 4:30 PM

Noncoding RNAs — Structure, biogenesis and function

HIV-1 matrix protein interactions with cellular tRNAs
Jason Ejimogu, University of Maryland, Baltimore County
Mechanisms of phosphorylation-mediated regulation of the RNAi effector protein argonaute 2
Brianna Bibel, Watson School of Biological Sciences
Long non-coding RNAs regulate NF-κB activation, inflammation and glucose metabolism
Subhrangsu Mandal, University of Texas at Arlington Chair
Analysis of long-noncoding RNA structure-function relationship in prostate cancer
Emily McFadden, Duke University
4:30 PM - 6:30 PM

CREST conversations: Connecting researchers, educators and students

Organized by the MSOE Center for BioMolecular Modeling

Dr. Celia Schiffer and colleagues from her lab will meet with undergraduate CREST (Connecting Researchers, Educators and Students) teams to discuss Dr. Schiffer’s research. 3D printed models of proteins studied in Dr. Schiffer’s lab, designed by CREST teams, will serve as shared mental models to facilitate discussion.

4:45 PM - 5:45 PM

Discoveries in membrane biology

Defining how viruses manipulate lipid phosphoinositides through activation of PI4P kinases to mediate viral replication
John Burke, University of Victoria Chair
Evidence for a novel interaction between key enzymes in the lipid biosynthesis pathway in S. cerevisiae
Brianna Greenwood, University of Alberta
4:45 PM - 5:45 PM

Enzyme structure and dynamics

Crystallographic snapshots of TsrM, a radical S-adenosylmethionine enzyme whose reaction is not so radical
Hayley Knox, Pennsylvania State University Chair
The role of the flexible loop in substrate recognition and catalysis in malate dehydrogenase
Alexandra Roessling, University of San Diego
Structural and functional characterization of fumarase C from Salmonella enterica
Ryan Maki, University of Wisconsin, La Crosse
Dynamic formation of the malate dehydrogenase/citrate synthase multienzyme complex
Toshihiro Obata, University of Nebraska-Lincoln
4:45 PM - 5:45 PM

Glycomics

Multi-omics studies reveal altered hippocampal N-glycosylation in high fat diet-induced obese mice
Mariana Barboza, University of California, Davis Chair
4:45 PM - 5:45 PM

Glycosyltransferase and glycan biosynthesis

Analyzing the effects of peters plus syndrome mutations on human β1,3-glucosyltransferase
Ao Zhang, University of Georgia
Novel insights into the fucose metabolism — challenging the old dogma
Paulina Sosicka, Sanford-Burnham-Prebys Medical Discovery Institute Chair
Protein structure, a new constraint for glycosyltransferase specificity: Template-like association between the glycoprotein surface on glycan structure
Benjamin Kellman, University of California San Diego
The structurally unusual retaining β-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step
Matthew Kimber, University of Guelph
4:45 PM - 5:45 PM

G-proteins mechanisms and catalysis

Interaction between Ras and the two Ras-binding domains of Raf kinase
Trinity Cookis, Northeastern University
Radil is a KRas-interacting protein involved in regulating cell adhesion and migration
Byeong Hyeok Choi, New York Uuniversity School of Medicine Chair
A mitochondrial recruitment assay to characterize a family of DENN-domain proteins, Rab GDP/GTP exchange factors
Rahul Kumar, Montreal Neurological Institute, McGill University
Lysophosphatidic acid promotes lung carcinoma cell migration via ARHGEF17, a RhoGEF directly controlled by Gβγ
Irving García, Cinvestav
4:45 PM - 5:45 PM

Metabolism and bioenergetics

Illuminating spatiotemporal regulation of AMPK with a genetically encoded excitation-ratiometric biosensor for AMPK
Danielle Schmitt, University of California, San Diego Chair
Characterization of clinically identified mutations in peripheral arm subunits NDUFV1, and NDUFS1 of respiratory complex I, using an E. coli model system
Hind Alkhaldi, Southern Methodist University
The role of ceramide synthases response to the heavy metal cadmium chloride
Margaret Peck, Juniata College
Analysis of assembly of complex I and characterization of clinically identified mutations in membrane subunits ND2, ND4, and ND5, using an E. coli model system
Fang Zhang, Southern Methodist University
4:45 PM - 5:45 PM

Regulation of lipid metabolism

Spatio-nutritional regulation of intestinal desaturases
Natalie Burchat, Rutgers University
Squalene monooxygenase at the nexus between cholesterol homeostasis and proteostasis
Ngee Kiat Chua, University of New South Wales, Sydney
SREBPs in the control of intestinal homeostasis and tumorigenesis
Luke Engelking, University of Texas, Southwestern
Alternate fatty acid synthesis initiation in Escherichia coli
Sarah Whaley, St. Jude Children's Research Hospital Chair
6:00 PM - 7:30 PM

Mentoring from both sides: How to find, be and utilize a great mentor

Mentoring should not be a scary or imposing concept — it's really just about getting and giving advice, support and encouragement for ongoing learning. This workshop is intended for everyone: trainees and faculty ready to learn practical tactics in identifying mentors, making the "ask" for mentoring support and how to take the best advantage of mentoring relationships — from both sides.

6:00 PM - 7:30 PM

Storytelling and the art of giving a great presentation

What’s in a story? The opportunity to form a compelling connection between science and its audience. Storytelling has long been used by journalists and artists to help explain complex ideas to broad audiences. Similarly, forming a narrative about your research will make it more accessible. This interactive session, based on a module from ASBMB’s training course, “The Art of Science Communication”, will offer participants training to better communicate their work.
6:00 PM - 7:30 PM

Organizing a successful ASBMB Student Chapter

6:00 PM - 7:30 PM

Emerging technologies in the glycosciences

In this workshop our goal is to promote the study of glycans, enabling participants to develop a more comprehensive understanding of the roles that glycans play in physiology and disease. Join us to meet colleagues, learn about innovative solutions to glycoscience problems, interact with vendors and participate in round table discussions focused on addressing glycoscience challenges. This workshop is ideal for both experts, researchers new to the field, and trainees. Presenters include Richard Drake, Kamil Godula, Catherine Grimes, Matt Pratt, Ajit Varki, Lance Wells and Natasha Zachara. Topics covered include approaches for glycoprotein engineering, glycomic and glycoproteomic approaches, the detection and analysis of sialic acids, modulation and detection of O-GlcNAc, tools for studying the bacterial cell wall, synthetic glycoconjugates for fine-tuning cell fate and educational opportunities.

Download a flyer

6:00 PM - 7:30 PM

Women Scientists Mentoring and Networking Event

ASBMB Leadership Awards will be presented to Natalia Jura and Anita Corbett.

Becoming a Resilient Scientist
Sharon Milgram, National Institutes of Health
6:00 PM - 7:30 PM

Forecasting the future: Setting yourself up with trustworthy data

Are you sure that the data you’re collecting today is as solid and secure as you’ll need it to be next week, month or year? Join ASBMB Data Integrity Manager Kaoru Sakabe and JBC Scientific Editor Catherine Goodman as they lead a panel discussion with researchers on good data stewardship. Learn how to avoid common mistakes, discuss habits and workflows, and get your questions answered to ensure you are doing all you can to generate enduring and reproducible research for the scientific community.

7:00 PM - 9:00 PM

ASBMB welcome reception

Sponsored by the Minority Affairs Committee

Monday agenda

8:00 AM - 8:30 AM

William C. Rose Award lecture

Constraining evolution → avoiding drug resistance: Lessons from viruses
Celia Schiffer, University of Massachusetts Medical School
8:30 AM - 9:00 AM

Mildred Cohn Award in Biological Chemistry lecture

Toolbox to evaluate biological function of histone deacetylases
Carol Fierke, Texas A&M University
9:00 AM - 11:00 AM

Antibiotic resistance: How to beat the bugs

Organized by the Society for Experimental Biology and Medicine

Co-Chairs: Peter Stambrook, University of Cincinnati Cancer Institute, and Warren Zimmer, Texas A&M College of Medicine

Jason Gill, Texas A&M University
Prashant Nagpal, University of Colorado
Rebekah Dedrick, University of Pittsburgh
9:15 AM - 11:15 AM

How lipids impact the structure and function of membrane proteins

Membrane proteins — the lipid connection
Carol Robinson, University of Oxford
Structural basis of lipid scrambling and ion conduction by TMEM16 scramblases
Alessio Accardi, Weill Cornell Medical College
Structural insights into TRPV channel gating
Vera Moiseenkova-Bell, University of Pennsylvania
Cardiolipin-dependent carriers
Steven Claypool, Johns Hopkins School of Medicine Chair
9:15 AM - 11:15 AM

Glycosylation and extracellular matrix in immunologic, inflammatory and infectious disease

Decoding inflammatory signals from the extracellular matrix for the development of new immunotherapies
Kim S. Midwood, University of Oxford Chair
Glycosylation in a common mechanism of colitis and sepsis
Jamey Marth, Sanford Burnham Prebys Medical Discovery Institute
Genome wide analysis of heparan sulfate assembly
Jeffrey D. Esko, University of California, San Diego
PAMPs, DAMPs and SAMPs. Host glycans are self-associated molecular patterns, but subject to microbial molecular mimicry
Ajit Varki, University of California, San Diego
9:15 AM - 11:15 AM

Post-translational modifications/signaling

Getting hedgehogs where they need to go
Stacey Ogden, St. Jude Children’s Research Hospital
Rhomboid proteins in cell signaling
Matthew Freeman, University of Oxford
Lipids and hedgehogs
Adrian Salic, Harvard University Medical School Chair
Role of notch glycoslation in signaling
Pamela Stanley, Albert Einstein College of Medicine
9:15 AM - 11:15 AM

Control of cell fate by metabolic intermediates

Chair: Carla Koehler, University of California, Los Angeles
Microbiome catabolites as novel modulators of cellular glucose and energy metabolism
Gary Williamson, Monash University
Metabolic modulation of cardiac health: The role of glucose and amino acids
Rong Tian, University of Washington
Control of macrophage activation by coenzyme A
Ajit Divakaruni, University of California, Los Angeles
A quantitative tissue-specific landscape of protein redox regulation during aging
Edward Chouchani, Harvard University
9:15 AM - 11:15 AM

Molecular motors

Chair: Nathan Adler, University of Connecticut

Integrated 3D tomography and computational modeling to study forces in metaphase spindles
Stefanie Redemann, University of Virginia School of Medicine
Single molecule biophysics
Carlos Bustamante, University of California, Berkeley
Myosin: Structure, function, regulation and disease
Michelle Peckham, University of Leeds
Watching a fine-tuned molecular machine at work: Structural and functional studies of the 26S proteasome
Andreas Martin, University of California, Berkeley
9:15 AM - 11:15 AM

RNA modifications and disease

RNA modification in cancer
Jianjun Chen, Beckman Research Institute of City of Hope
RNA modifications in health and disease
Tsutomu Suzuki, University of Tokyo
Acetylation of cytidine in messenger RNA regulates translation
Shalini Oberdoerffer, National Cancer Institute
tRNA quality control: Mechanisms, evolution and implications for human disease
Eric Phizicky, University of Rochester Medical Center Chair
9:15 AM - 11:15 AM

Computational approaches to regulation of gene expression

Leveraging microfluidics for high-throughput studies of transcription factor/DNA binding
Polly Fordyce, Stanford University Chair
Synthetic NF-kB: A building approach to study complex signaling behaviors
Ping Wei, Peking University Center for Quantitative Biology
Accurate annotation of protein-coding small open reading frames in the human genome
Thomas Martinez, Salk Institute for Biological Studies
Slow molecular recognition by RNA
Raghuvir Sengupta, Stanford University
9:15 AM - 11:15 AM

What we do: Choosing pedagogy over content

Chair: Nathan Vanderford, University of Kentucky

Teaching biochemistry in context
Daniel Dries, Juniata College
Using narrative in STEM education
Reneta Lansiquot, New York City College of Technology
Reimagining STEM education to help underrepresented students thrive in the classroom
Shannon Z. Jones, University of Richmond
11:30 AM - 12:45 PM

Meet the speakers

12:30 PM - 1:45 PM

Poster sessions

12:30 PM - 1:00 PM

What you can do with a Ph.D. in biology

Micro-learning Hub
Dorit Zuk, National Institute of General Medical Sciences
1:00 PM - 3:00 PM

Role of R-loop formation in human disease

Organized by the Society for Experimental Biology and Medicine

Chair: Edward Motea, Indiana University Simon Comprehensive Cancer Center

James Manley, Columbia University
Julio C. Morales, University of Oklahoma Health Sciences Center
1:30 PM - 2:00 PM

Picture perfect: How to present an image for scientific publication

Micro-learning Hub
Kaoru Sakabe, ASBMB
2:00 PM - 2:30 PM

Ruth Kirschstein Diversity in Science Award lecture

Getting there: Thyroid hormone receptor intracellular trafficking
Lizabeth Allison, College of William & Mary
2:30 PM - 3:00 PM

Walter A. Shaw Young Investigator Award in Lipid Research lecture

Shedding light on phosphatidic acid signaling with chemical tools
Jeremy Baskin, Cornell University
3:00 PM - 5:00 PM

Synthetic biology

Organized by the Society for Experimental Biology and Medicine
3:15 PM - 5:00 PM

Alice and C.C. Wang Award in Molecular Parasitology symposium

Host parasite interactions between the sexually-transmitted parasite trichomonas vaginalis and its human host
Patricia Johnson, University of California, Los Angeles
Chi-Min Ho, Columbia University Irving Medical Center
Interaction of the microbiome, the mucosal immune system and the parasite
William Petri, University of Virginia
Stephen Beverley, Washington University in St. Louis
3:15 PM - 4:15 PM

Exciting biological insights revealed by proteomics: A Molecular & Cellular Proteomics presentation

Chair: Al Burlingame, University of California, San Francisco

Ultra-high throughput analysis of histone modifications for cancer epigenetics
Benjamin Garcia, University of Pennsylvania
Proximity dependent BioID sensors define a role for HOPS in macropinocytosis-dependent control of cell growth
Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute
3:15 PM - 5:30 PM

Enzyme regulation by filamentation and other alternate and emerging mechanisms

Exploring structural determinants and functional aspects of micron-scale protein assemblies in living cells
Tal Levin, Weizmann Institute of Science
Filament formation enables highly cooperative regulation of human CTP synthase 2
Eric Lynch, University of Washington
The filament forming mechanism of SgrAI endonuclease-structural and kinetic analysis
Nancy Horton, University of Arizona Chair
Enzyme polymerization in nucleotide biosynthesis
Jeff Peterson, Fox Chase Cancer Center
Identification of an actin fold containing metabolic enzyme that undergoes regulated polymerization
Jim Wilhelm, University of California, San Diego
Regulating ER protein homeostasis by differentially processing mRNAs
Weihan Li, Albert Einstein College of Medicine
The oligomerization status of IRE1α kinase/RNase determines its signaling outputs under endoplasmic reticulum stress
Scott Oakes, University of Chicago
Filament assembly by the liver phosphofructokinase-1, the “gatekeeper” of glycolysis
Bradley Webb, West Virginia University
3:15 PM - 4:15 PM

Constructing authentic learning experiences

Too many carrots: Are we preparing our students effectively for life-long learning?
Orla Hart, Purdue University Chair
Learning focus: Scaffolded primary literature curriculum for improved student skills
Keith Miller, University of Mount Union
CUREing ocean plastic microbes: Positive experience of engaging non-traditional undergraduate students in a Hispanic-serving institution
Ana Maria Barral, National University
An invitation to modeling
Kam Dahlquist, Loyola Marymount University
3:15 PM - 4:15 PM

DNA repair

Exo1-independent MMR at euchromatin is error-prone and involves Pol ζ and Rev1
Vaibhavi Gujar, Southern Illinois University, Carbondale
DNA clamp loader subunit DnaX gamma plays a role in the response to DNA damage
Tommy Tashjian, University of Massachusetts, Amherst
Small but greedy: A minimal rDNA array outcompetes the genome for replication initiation
Elizabeth Kwan, University of Washington
The herpes simplex viruses utilize a recombination-dependent replication mechanism to replicate viral genomes
Savithri Weerasooriya, University of Connecticut Health Chair
3:15 PM - 4:15 PM

Glycosylation and extracellular matrix in immunologic, inflammatory and infectious disease

Designing 3D synthetic matrices for studying interactions between bacterial peptidoglycan and macrophages in the context of immune misrecognition diseases
Kimberly Wodzanowski, University of Delaware
A tool to predict affinity and specificity of GAG binding to proteins
Umesh Desai, Virginia Commonwealth University
Natural and synthetic glycan arrays for probing interactions of the innate and adaptive immune system with zwitterionic oligosaccharides
Iain Wilson, University of Natural Resources and Life Sciences, Vienna
Inhibition of Clostridium difficile TcdB toxin with transition state analogues
Ashleigh Paparella, Albert Einstein College of Medicine Chair
3:15 PM - 4:15 PM

Lipid–protein interactions

Them1 binds to free fatty acids and is allosterically regulated by lysophosphatidylcholine to control fatty Acyl-CoA hydrolysis in brown adipose tissue
Matthew Tillman, Emory University
Redefining the specificity of phosphoinositide binding by human PH domain-containing proteins
Nilmani Singh, University of Illinois at Urbana-Champaign
Structural basis for the utilization of host fatty acids by bacterial fatty acid binding proteins
Jessica Gullett, St. Jude Children's Research Hospital
Crystal structure of the human phospholipase D1 catalytic domain provides insight into activation by PI(4,5)P2 and RhoA
Michael Airola, Stony Brook University Chair
3:15 PM - 4:15 PM

Lipids in inflammation

Pentalinonsterol exhibits the immunomodulatory action in macrophages through activation of Phospholipase A2
Sanjay Varikuti, Ohio State University
In vivo metabolomic and lipidomic response of healthy humans to intravenous lipopolysaccharide challenge
William Bresette, University of Arizona
Modulation of airway remodeling by PF543, a sphingosine kinase 1 inhibitor, in a mouse model of bronchopulmonary dysplasia
Tara Sudhadevi, University of Illinois at Chicago Chair
Nogo-B deficiency inhibits high-fat diet-induced obesity by reducing NF-κ B-mediated inflammation
Xiaolin Wang, Nankai University
3:15 PM - 4:15 PM

Methods and mechanobiology

A MAP kinase-driven mechanical stress response mediates the hypertrophic response in skeletal muscle
Cathrine Nordgaard, University of Copenhagen
Cell-cell and cell-extracellular matrix communication pathways identified in the polarized surface proteome of retinal pigment epithelial cells
Paulo Caceres, Weill Cornell Medicine Chair
Optogenetic control of the Sphingosine-1-phosphate receptor 1 enables light-mediated regulation of endothelial permeability and angiogenesis
Hojin Kang, University of Illinois at Chicago
Ligand binding induces conformational flexibility transitions of the epidermal growth factor receptor dimer
Ei-ichiro Saita, Okinawa Institute of Science and Technology Graduate University
3:15 PM - 4:15 PM

Microbe/parasite host interactions

Wnt5A signaling mediated cytoskeletal actin modulations shape the outcome of host-bacteria interactions
Suborno Jati, CSIR - Indian Institute of Chemical Biology
NEIL2 plays a critical role in limiting inflammation and preserving genomic integrity in H. pylori-infected gastric epithelial cells
Ibrahim Sayed, University of California San Diego Chair
Deciphering the role of a unique methyltransferase in mycobacterial infection
Anshu Rani, Indian Institute of Technology, Delhi
Determining the effects of legionella pneumophila side effector proteins on host vesicular trafficking
Michelle Favichia, University of Delaware
3:15 PM - 4:15 PM

NAD synthesis, salvage and sirtuins in tissue health

NAD redox imbalance drives diabetic cardiomyopathy: Roles of oxidative stress and post-translational modifications
Chi Fung Lee, Oklahoma Medical Research Foundation
A click chemistry approach to reveal the chromatin-dependent histone H3 K36 deacetylase nature of SIRT7
Wenshe Liu, Texas A&M Univeristy
Particulate matter activates SIRT1-SREBP1-PIR pathway to promote pulmonary fibroblast inflammation and enhance lung fibrosis
Chia-Ping Tien, Academia Sinica Genomics Research Center Chair
Ageing signalling pathways: Quantifying the effects of protein interactions
Mehrshad Sadria, University of Waterloo
3:15 PM - 4:15 PM

RNA structure and RNA binding proteins

Small molecule inhibits enterovirus 71 replication by targeting the IRES domain
Jesse Davila-Calderon, Case Western Reserve University
Broken heart: disruption of the RNA binding protein rbm24a alters heart morphogenesis and leads to cardiomyopathy
Lindy Brastrom, University of Iowa
The phases that separate RNA and transcription
Jacob Schwartz, University of Arizona Chair
RNA binding protein FXR1-miR301a-3p axis contributes to p21WAF1 degradation in oral cancer
Mrinmoyee Majumder, Medical University of South Carolina
3:15 PM - 4:15 PM

Steps toward equity in STEM

An anti-racist classroom in the natural sciences
Neena Grover, Colorado College
Women in STEM — Intrinsic and extrinsic factors that impact retention and yield
Marilee Benore, University of Michigan–Dearborn Chair
Best practices for inclusion of deaf and hard-of-hearing scientists at conferences
Paul Craig, Rochester Institute of Technology
Science advocacy serves communities and scientists
Shannon Kozlovich, University of California, San Francisco
4:30 PM - 5:30 PM

Cancer biology and biochemistry

The F-box protein FBXL16 upregulates the stability of c-myc oncoprotein by antagonizing FBW7 function
Marion Morel, Wright State University
EGFR signaling in breast cancer requires licensing from separate membrane nanodomains
Michael Sugiyama, Ryerson University Chair
Epigenetic reprogramming driven by metabolic alterations as a mechanism of EGFR — Tyrosine kinase inhibitor resistance in human lung adenocarcinoma
Abhilash Venugopalan, National Cancer Institute
TIFA-NF-κB axis modulates inflammatory microenvironment to offset sorafenib cytotoxicity in hepatocellular carcinoma
Tong-You Wade Wei, Academia Sinica
4:30 PM - 5:30 PM

Enzyme catalysis and mechanism

Revealing the function of a linker in the multi-functional regulatory protein — proline utilization A from Escherichia coli
Yizi Mao, University of Nebraska, Lincoln
The mechanism of activating mutations of the protein tyrosine phosphatase SHP2
Ingrid Marko, Brandeis University Chair
Determining the activation energy of photoassembly of the oxygen-evolving complex using an alternative redox mediator
Ethan Napier, Marshall University
A proposed proton relay mechanism in methylenetetrahydrofolate reductase
Yuwei Pan, Grinnell College
4:30 PM - 5:30 PM

Glycomics and glycoinformatics

GlyGen — Computational resources for glycoscience
Michael Tiemeyer, University of Georgia Chair
Simple and rapid slide-based mass spectrometry workflows applied to N-glycan analysis of cells, biofluids and antibody arrays
Richard Drake, Medical University of South Carolina
Exploring the scope of high throughput micro-permethylation based glycomics
Asif Shajahan, University of Georgia Complex Carbohydrate Research Center
Systems glycoengineering: Integrated analyses of glycomics, transcriptomics and phenotypic data reveal complex cellular response to glycoengineering in CHO cells
Wan-Tien Chiang, University of California, San Diego
4:30 PM - 5:30 PM

Molecular machines

Structure-based insights into control of heme biosynthesis
Breann Brown, Vanderbilt University Chair
The molecular mechanism of cellular attachment for an archaeal virus
C. Lawrence, Montana State University
The plasma membrane translocation of HspA1A, a stress inducible 70-kDa heat shock protein, depends on its interaction with membrane lipids
Larissa Smulders, California State University, Fullerton
Kinetic effects of inside-positive membrane potential on the lactose efflux of LacY
Xiaoxu Jiang, University of California, Los Angeles
4:30 PM - 5:30 PM

New insights into control of metabolism by transporters

Assessing the epigenetics effects on the expression of the Fabp3 promoter region of Zinc-Transporter 7-deficient mice
Victoria Scherpel, University of California, Davis
Review of riboflavin transporter deficiency syndrome: Sameness in genotype occurs with variations in phenotype
Christopher Ukpong, University of Science, Arts and Technology, Montserrat
The effect of SERCA2 activation on liver metabolism during acute lipotoxicity in vivo
Tomasz Bednarski, Vanderbilt University Chair
Do folding elements trade-off with function in the human mitochondrial metabolite transporter?
Radhakrishnan Mahalakshmi, Indian Institute of Science Education and Research
4:30 PM - 5:30 PM

Protein stability

Mode of protein targeting to the proteasome determines substrate fate
Christopher Braganca, Villanova University
Cargo binding of an adaptor directly competes with oligomerization
Nathan Kuhlmann, University of Massachusetts, Amherst
p23 co-chaperone protects aryl hydrocarbon receptor (AHR) from the autophagy-mediated degradation
Yujie Yang, University of the Pacific
K48 linked ubiquitin chains affect proteasomal unfolding ability via interactions with Rpn10
Joseph Boscia IV, Villanova University Chair
4:30 PM - 5:30 PM

Proteomics

Multi-omics approach identifies differences between cranial and spinal motor neuron — A step towards understanding ALS
Shuvadeep Maity, New York University
Molecular signatures of neuroinflammation induced by α-synuclein aggregates in microglial cells
Souvarish Sarkar, Harvard Medical School Chair
The EGFR liver regeneration pathway is downregulated in alcoholic hepatitis
Josiah Hardesty, University of Louisville
Network analysis of the brain proteome of GRN knockout mice reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations
Meixiang Huang, Emory University
4:30 PM - 5:30 PM

Regulatory mechanisms in lipid biology

mTORC1 is required for the lipidation and ER-to-Golgi transport of prechylomicrons in Caco-2 cells
Regis Moreau, University of Nebraska-Lincoln
Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally
Isabelle Capell-Hattam, University of New South Wales, Sydney
Protein and membrane trafficking in a dextran sulfate sodium-induced ER stress in absorptive intestinal Caco-2 cells
Dalanda Wanes, University of Veterinary Medicine, Hanover
How SFR2 is regulated to confer freezing tolerance of the chloroplast envelope membrane
Rebecca Roston, University of Nebraska-Lincoln Center for Plant Science Innovation Chair
4:30 PM - 5:30 PM

Signaling the actin cytoskeleton and cell motility

The mechanism of actin remodeling by the BAR domain of ArfGAP ASAP1
Anjelika Gasilina, National Cancer Institute Chair
Interleukin-16 signaling through the CD9 receptor initates rearrangement of the actin cytoskeleton
Lindsey Charley, Fort Lewis College
Examining the role of p190RhoGAP on the organization of the actin cytoskeleton in breast epithelial cells
Courtney Robinson, Saint Mary's College of California
Dynamic phosphorylation and dephosphorylation of CAP1 (cyclase-associated protein 1) by antagonistic signaling through CDK5 and cAMP are critical for the protein functions in actin filament disassembly and cell adhesion
Yitong Xiao, New York Institute of Technology College of Osteopathic Medicine at Arkansas
5:45 PM - 7:15 PM

Education and professional development workshop

5:45 PM - 7:15 PM

Transforming science research into outreach

Many scientists wish to become more involved in science outreach. But, how to get started? Attend this interactive workshop to learn more! Members of the Science Outreach and Communication Committee and an invited speaker will showcase examples of how to turn scientific research projects into outreach activities aimed at diverse audiences. Then, work on your own science outreach project with feedback and suggestions from peers.
5:45 PM - 7:15 PM

Using 3D to teach structure-function and computers to teach metabolic systems

Rebecca RostonTomas Helikar and Christine Booth, University of Nebraska–Lincoln
Michelle Howell, LCC International University

This workshop takes participants through a comprehensive suite of modules demonstrated to improve educational outcomes in two core undergraduate biochemistry concepts. The first module helps students build accurate mental models of 3D macromolecular structures from 2D images. The second targets how metabolism works not only in discrete modules (e.g., glycolysis, citric acid cycle, electron transport chain) but also as part of larger and dynamic interconnected systems within cells and organisms. Participants will each receive a 3D-printed macromolecule model set and a set of printable coordinates for additional model sets. Additionally, participants will also receive training in software designed for using modeling and simulations to teach about metabolism and other complex biological systems. Finally, instructor materials (associated slides and assessments) will be provided to make classroom incorporation as easy as possible. We will also share strategies and techniques on how to assess student perceptions and modify incorporation for optimal student engagement. Food will be provided.

5:45 PM - 7:15 PM

The journey from academia, to industry to entrepreneurship: How to find a job, build a career and/or a company, outside of the ivory tower

The goal of this workshop is to ensure that the audience gets at least several good take-home ideas for the further development of their industry careers, whether it is to land a first job interviewing/networking skills) or to progress on in a company career or become an entrepreneur. Panelists will tell their own, unique stories of how they’ve moved from academic scientist to industry scientist — and company founders! This workshop will benefit graduate students, postdocs or any job seeker interested in the furtherance of their career outside of academia.

5:45 PM - 7:15 PM

Structure matters – 21 strategies to promote engagement, fairness and inclusion in learning environments

Teaching diverse populations requires instructors to construct learning environments that are inclusive and equitable. Research in psychology and other disciplines suggests that how individuals personally experience learning environments strongly influences engagement, motivation, sense of belonging and conceptual learning. In this interactive workshop, participants will share a common experience as the basis for discussing how students may experience classroom environments differently from one another. Individual participants will then have the opportunity to self-assess their current awareness of 21 common equitable teaching strategies and identify those that could be immediately implemented in their classrooms, lab meetings and other learning environments.

6:00 PM - 7:30 PM

Science in a Flash

Join us for the second annual science communication competition. This event features 10 speakers who will share their science in just three minutes with only one slide. In addition to distilling their research down to its essence, presenters must work to eliminate scientific jargon so that their presentation is understood by specialists and non-specialists alike. The audience will play a major role in selecting winners, so join us and vote for your favorite.

Tuesday agenda

8:30 AM - 9:00 AM

Bert and Natalie Vallee Award in Biomedical Science lecture

Enzyme hydrophobic sites and allosteric membrane interactions regulate signaling and mediators of inflammation
Edward Dennis, University of California, San Diego
9:00 AM - 11:00 AM

Intracellular trafficking

Organized by the Society for Experimental Biology and Medicine

Chair: Vinita Takiar, University of Cincinnati

Sima Lev, Weizmann Institute
Ora Weisz, University of Pittsburgh
Michael Caplan, Yale University
9:15 AM - 11:15 AM

Membrane biogenesis and trafficking

Chair: Teresa Dunn-Giroux, Uniformed Services University

Lipid droplet proteome dynamics and lipotoxicity
James Olzmann, University of California, Berkeley
Mechanistic approaches towards understanding physicochemical membrane homeostasis in the endoplasmic reticulum
Robert Ernst, Saarland University
The role of VPS13 and related proteins in glycerolipid transport at membrane contact sites
Karin Reinisch, Yale University School of Medicine
Cold-induced lipid dynamics in thermogenic fat
Yu-Hua Tseng, Harvard University Medical School
9:15 AM - 11:15 AM

Glycosylation and extracellular matrix in neurologic and metabolic diseases

Chair: Jamey Marth, Sanford Burnham Prebys Medical Discovery Institute

The role of the O-GlcNAc transferase interactome in X-linked intellectual disability
Lance Wells, University of Georgia Complex Carbohydrate Research Center
Role of ECM in the brain-gut connection
Fernando Gomez-Pinilla, University of California, Los Angeles Brain Injury Research Center
The role of metabolism in modulating radiation fibrosis
Fei-Fei Liu, Princess Margaret Cancer Centre, Toronto
9:15 AM - 11:15 AM

Emerging mechanisms of signaling

Chairs: Wendy Gordon, University of Minnesota, and Adrian Salic, Harvard Medical School

Tuning receptor signaling through ligand engineering
Chris Garcia, Stanford University
Cellular communication via adhesion
Demet Arac, University of Chicago
Mechanisms of Wnt5a-Ror signaling in development and disease
Henry Ho, University of California, Davis
Genetic and acquired heterotopic ossification are driven by a self-amplifying positive feedback loop of Hedgehog signaling
Yingzi Yang, Harvard University Dental School
9:15 AM - 11:15 AM

New insights into control of metabolism by transporters

Chair: Marcia Haigis, Harvard Medical School

Glutamine transporter as a target of mTOR signaling modulating longevity
John M. Sedivy, Brown University
Beneficial effects of inhibition of the mitochondrial pyruvate carrier and the mechanism of action of thiazolidinediones
Anne Murphy, Cytokinetics, Inc.
Local and systemic actions of hepatic fatty acid oxidation
Michael Wolfgang, Johns Hopkins University School of Medicine
Role of mitochondrial calcium in the maintenance of skeletal muscle homeostasis
Anna Raffaello, University of Padova
9:15 AM - 11:15 AM

RNA binding proteins and control of RNA biogenesis in disease

Reprogramming cell fates by RNA binding proteins in stem cells and cancer
Takahiro Ito, University of Georgia Chair
The RNA exosome and genetic disease
Anita Corbett, Emory University
RNA, chromatin and the coordinated control of gene expression
Tracy Johnson, University of California, Los Angeles
Connections between mRNP composition and mRNA fate
Guramrit Singh, Ohio State University
9:15 AM - 11:15 AM

Best practices for preventing/managing incidences of harassment in the workplace

9:15 AM - 11:15 AM

EB joint symposium: Research on cannabidiol

CBD and neuroprotection
José Martínez-Orgado, Hospital Clínico San Carlos, Madrid
CBD and intestinal health
Tiffany Weir, Colorado State University
CBD effects on behavior and reproduction
Kristine Willett, University of Mississippi
CBD effects on endocannabinoid signaling
Kenneth Mackie, Indiana University
9:30 AM - 11:30 AM

Molecular motors in transport, biosynthesis and energy transduction

An AAA-ATPase using an airlock-like translocation mechanism for folded proteins
Roland Beckmann, Ludwig Maximilian University of Munich
Functional assembly of the mitochondrial protein transport machinery
Nathan Alder, University of Connecticut Chair
Structure of the alternative complex III from flavobacterium johnsoniae in a supercomplex with cytochrome c oxidase
Robert Gennis, University of Illinois
Nascent protein selection and triage at the ribosome exit site
Shu-ou Shan, California Institute of Technology
10:30 AM - 11:00 AM

How to get started with science writing

Micro-learning Hub
Laurel Oldach, ASBMB
11:30 AM - 12:45 PM

Meet the speakers

12:30 PM - 1:45 PM

Poster sessions

12:30 PM - 1:00 PM

How to get published

Micro-learning Hub
Catherine Goodman, ASBMB
2:00 PM - 3:00 PM

Lipid Diversity and Disease: Spotlight on Journal of Lipid Research Junior Associate Editors

Raymond Blind, Vanderbilt University Medical Center
Rotonya Carr, University of Pennsylvania
Brandon Davies, University of Iowa
Gissette Soffer, Columbia University
2:00 PM - 3:30 PM

Improving visual literacy using augmented reality and LEGO® bricks in biology classrooms

Organizers: Swati Agrawal, University of Mary Washington, and Shane Austin, University of the West Indies

This interactive workshop provides participants with hands-on experience with the use of augmented reality and LEGO® bricks to explain course content. We have developed a series of lessons focused on DNA and protein structure, function and interaction where AR and LEGO® bricks are used to provide 3 dimensional interactive models that help students better visualize these intricate structures and processes in our classes. Lessons will cover concepts such as: levels of organization in protein structure, domains in protein involved in metabolic pathways, and protein–DNA interaction during processes involved in transcription. After the brief presentation, participants will use these lessons to experience and assess the learning gains of this activity and will learn how to develop content for AR using free and easily available platforms so they are able to generate content suited for their courses. Finally, ideas about possible classroom assessments will be presented.

Target audience: instructors or students from 2-year or 4-year college. Emphasis will be placed on examples relevant to biochemistry, molecular biology and cell biology, however, techniques could be applied to wider biology educator audiences.

2:00 PM - 3:00 PM

Antibiotic resistance

Transcriptome-based design of PNA inhibitors re-sensitizes CRE E. coli to carbapenems
Thomas Aunins, University of Colorado, Boulder
Three self-resistance modifications discovered in nucleoside antibiotic muraymycin
Zheng Cui, University of Kentucky Chair
Ecm16 protein confers resistance against the DNA intercalator antibiotic echinomycin
Priyanka R. Gade, University of Texas at El Paso
Small changes of active site residues of an acinetobacter aminoglycoside acetyltransferase affect antibiotic susceptibility
Anjani Pradhananga, San Francisco State University
2:00 PM - 3:00 PM

Chemical biology/drug discovery

Novel 2-oxoglutarate analogues modulate the epigenetic activity of the cancer-related human enzyme aspartate/asparagine-&[beta]-hydroxylase
Lennart Brewitz, University of Oxford Chair
New chemical probes for detection of molecular markers of multiple sclerosis
Nicholas Dacon, University of Wisconsin–Stout
HYPE-mediated AMPylation as a novel therapeutic target for neurodegeneration
Ali Camara, Purdue University
Bacterial cell wall modification by glycolipid probes
Victoria Marando, Massachusetts Institute of Technology
2:00 PM - 3:00 PM

DNA recombination structure and topology

Structural and functional characterization of the integrase HK022
Madison Kennedy, University of Washington Chair
Inter-domain protein-protein interaction through a unique α-helix in the hinge region of E. coli topoisomerase I leads to the conformational change of the enzyme
Tumpa Dasgupta, Florida International University
An approach to measure the effect of bridging protein size on DNA loop probability
Brooke Tader, Mayo Clinic
Pre-steady state kinetic analysis of DnaE polymerase illuminates the limited (but essential) role it performs in gram-positive DNA replication
Sean Fagan, State University of New York at Albany
2:00 PM - 3:00 PM

Glycosylation and extracellular matrix in neurologic and metabolic diseases

Assembly of hypothalamic perineuronal nets contributes to sustained blood glucose lowering by FGF1 action in the brain
Kimberly Alonge, University of Washington Medicine Diabetes Institute Chair
Adipose tissue heparan sulfate proteoglycans — critical regulators of adipocyte metabolism and glucose homeostasis
Ariane Pessentheiner, University of California, San Diego
Exploring the role of amyloid-beta precursor protein (APP) O-glycosylation in alzheimer's disease
YashoNandini Singh, Florida Atlantic University
A TGFβ1-BIGH3-apoptosis axis comprising peptidase and integrin α3β1 promotes renal cell death
Richard LeBaron, University of Texas at San Antonio
2:00 PM - 3:00 PM

IDP

Charge neutralization tunes dynamic arrest of initially disordered reflectin proteins
Robert Levenson, University of California, Santa Barbara Chair
Competing modes of assembly restrict amyloid formation by a neurodegenerative protein, TDP43
Jianzheng Wu, Stowers Institute for Medical Research
Liquid-liquid phase separation by the Egr transcriptional coregulator NAB2
Adele Correia, Bridgewater State University
Elucidating the open and active conformation of human 5-lipoxygenase
Eden Gallegos, Louisiana State University
2:00 PM - 3:00 PM

mRNA splicing, processing, nuclear export and turnover

The search for novel splicing factors: Mapping mutations in a temperature-sensitive Schizosaccharomyces pombe library
Jelani Williams, Ithaca College
RNA-binding protein QKI is a critical pre-RNA splicing regulator for cardiac development and function
Ying Liu, Indiana University
Molecular basis for the exploitation of nuclear mRNA export by influenza A virus
Yi Ren, Vanderbilt University Chair
Histone mRNA uridylation: Oligo(U) tail, or stem-loop?
Patrick Lackey, Westminster College
2:00 PM - 3:00 PM

New technology

Signaling diversity enabled by Rap1 and cAMP/PKA-regulated plasma membrane ERK with distinct temporal dynamics
Jeremiah Keyes, University of California, San Diego
Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly
Barry Willardson, Brigham Young University Chair
Subcellular drug targeting illuminates local action of polo-like kinase 1 and aurora A during mitosis
Paula Bucko, University of Washington
An ultrasensitive fluorescent biosensor for multi-modal kinase activity detection and high-resolution imaging in awake mice
Sohum Mehta, University of California, San Diego
2:00 PM - 3:00 PM

Structure and function of molecular machines

A module swapping approach to engineer allosterically regulated transcriptional regulators
Clement Chan, University of Texas at Tyler Chair
Modulation of GPCR function by membrane lipids and water
Nipuna Weerasinghe, University of Arizona
Structural studies of human Fis1 reveals a dynamic region important for Drp1 recruitment and mitochondrial fission
Blake Hill, Medical College of Wisconsin
Generation of the configurational ensemble of an intrinsically disordered protein
Loukas Petridis, Oak Ridge National Laboratory
3:15 PM - 4:15 PM

Antibiotic targets and drug discovery

A putative cystathionine beta-synthase homolog of mycobacterium smegmatis is involved in de novo cysteine biosynthesis
Saroj Mahato, University of Arkansas Chair
Discovery of small molecules that sensitize Salmonella to polymyxin antibiotics
Michaela Thielen, University of Wisconsin-La Crosse
Strong antimicrobial activity of hydroxamic acids and newly synthesized derivatives
Daniel Antunes, New Jersey City University
Inhibiting heptosyltransferase to combat gram-negative bacterial infections
Alvin Wang, Wesleyan University
3:15 PM - 4:15 PM

Cell decision making

Correcting for sparsity and non-independence in glycomic data through a systems biology framework
Bokan Bao, University of California, San Diego
Computed cell-cell interactions correlate with physical location of cells in C. elegans
Erick Armingol, University of California, San Diego Chair
Electrostatic and chemical properties in natural and designed enzymes
Mary Jo Ondrechen, Northeastern University
Coevolution of secreted proteins and members of the secretory pathway reveals interactions and motifs used for proper secretion
Isaac Shamie, University of California, San Diego
3:15 PM - 4:15 PM

Control of cell fate by metabolic intermediates/O-GlcNAc

Lafora disease: Differential metabolic disturbances in neurons and astrocytes
Kia Hjulmand Markussen, University of Kentucky
Proteomics analysis of a phage-bacterium interaction reveals both hijacking and suppression of host metabolic processes
Ikenna Okekeogbu, Purdue University
Hypoxia-induced annexin A6 expression underlies the metabolic vulnerability and response of TNBC cells to EGFR-tyrosine kinase inhibitors
Stephen Williams, Meharry Medical College
Linking energy metabolism to cell fate decision during kidney development
Giovane Tortelote, Tulane University Chair
3:15 PM - 4:15 PM

Enzyme regulation

Dynamics of allosteric activation in PLC-γ isozymes
Edhriz Siraliev-Perez, University of North Carolina at Chapel Hill Chair
The complete molecular analysis of PTP1B function
Kristiane Torgeson Pelletier, University of Arizona
Development of 19F NMR as a novel tool to study P450 redox protein interactions
Christopher Campomizzi, State University of New York at Buffalo
Tryptophan-75 is a potential gating residue of cytochrome P450 2D6 
Kevin McCarty, Kalamazoo College
3:15 PM - 4:15 PM

Genomics

Molecular mechanisms of stem cell reprogramming by CD47 antagonists in primary human cells
Kyle Cicalese, National Cancer Institute Chair
Identifying protein expression changes in acute myeloid leukemia
Mika Caplan, University of Nebraska-Lincoln
Urine metabolomics and proteomics for bladder cancer prediction by LC/MS based strategy
Xiaoyue Tang, Chinese Academy of Medical Science
Synovial fluid sequencing: A look into the future of prosthetic joint infection detection
Lavinia Unverdorben, Juniata College
3:15 PM - 4:15 PM

Molecular motors

Chair: Jochen Zimmer, University of Virginia

The role of mobility in flavivirus protease substrate selection
Jeanne Hardy, University of Massachusetts
Targeting of the membrane-anchored Rab GAP (GTPase accelerating protein) Gyp8 to peroxisomes is regulated by the AAA ATPase Msp1
Daniel Nickerson, California State University, San Bernardino
Two alternative mechanisms regulate the onset of chaperone-mediated assembly of the proteasomal ATPases
Soyeon Park, University of Colorado, Boulder
Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex
Walid Houry, University of Toronto
3:15 PM - 4:15 PM

Nanotechnology

Tailoring HDL mimetics for in vivo delivery of mRNA
Wei He, Lawrence Livermore National Laboratory
Comparing transcriptome profiles of silver, cadmium selenide/zinc sulfide, indium phosphide/zinc sulfide, and palladium quantum dots in Saccharomyces cerevisiae
Cullen Horstmann, Missouri State University
Piezo-electric based ultraprecise/ultratrace 3D food printing of potato resistant starch
Soyeong Jeong, Ewha Womans University
Peptide-stabilized nanomaterials for drug delivery and cancer therapy
Sylwia Dragulska, Brooklyn College Chair
3:15 PM - 4:15 PM

Novel tools for lipid research

In vitro physiological membrane-on-a-chip and its application in cell and neuronal biology
Paul Heo, Ecole Normale Supérieure de Paris
Biochemical analysis of phosphoethanolamine methyltransferase from Eimeria tenella
Daniel Etoroma, University of North Carolina, Wilmington
Unraveling the metabolic and machinery constraints on protein secretion through a novel systems biology framework
Nathan Lewis, University of California, San Diego Chair
Elimination of the "essential" Warburg effect in mammalian cells through a multiplex genome engineering strategy
Nathan Lewis, University of California, San Diego
3:15 PM - 4:15 PM

Organelles and trafficking

The connector between the kinase and RNase domains of IRE1 α differentially controls the activities of this stress sensor
Daniela Ricci, The Children's Hospital of Philadelphia Chair
Structural details of GEF-mediated Sar1 activation
Aaron Joiner, Cornell University
Cytosolic Ca2+ modulates Golgi structure through PKC-mediated GRASP55 phosphorylation
Stephen Ireland, University of Michigan
Caveolin-1 frame-shift mutation induce changes in cellular morphology and function
Juan Pablo Zuniga Hertz, University of California, San Diego
3:15 PM - 4:15 PM

Protein engineering

SAXS-enabled macromolecular engineering at SIBYLS
Curtis Hodge, Lawrence Berkeley National Laboratory Chair
Optimization of cell-free protein synthesis through identification of rate-limiting factors
Philip Smith, California Polytechnic State University, San Luis Obispo
The biological activity of extracellular matrix mimetic elastin-like polypeptide-laminin α1 peptide
Anh Truong, University of Southern California
Using synthetic biology methods to construct a dual functional estrogen biosensor
Farhiya Yusef, Simmons University
3:15 PM - 4:15 PM

Roles of O-GlcNAc in biology

Targeting the O-GlcNAc transferase to specific proteins using RNA aptamers
Yi Zhu, Johns Hopkins University Chair
Fluvastatin decreases endothelial nitric oxide synthase O-glcnacylation by decreasing glucose uptake
Samantha Bohlman, University of Maryland
O-GlcNAc transferase regulates growth factor signaling and extracellular matrix composition in idiopathic pulmonary fibrosis
Shia Vang, University of Alabama at Birmingham
Linking maternal sugar consumption to progenies' developmental defects: A focus on OTX2's O-GlcNAcylation
Eugenia Wulff, Medical College of Wisconsin
3:15 PM - 4:15 PM

The pleitopic roles of lipids in disease

Lipid metabolism changes in C. elegans models of aging
Jason Chan, Marian University Chair
Cardiomyocyte Krüppel-like factor 5 regulates ceramide biosynthesis and miR-30 suppression in ischemic cardiomyopathy and promotes systolic dysfunction
Matthew Hoffman, Temple University
Differential effects of n-3 and n-6 fatty acids on inflammatory cytokine production in 3T3-L1 adipocytes and RAW264.7 macrophages
Cristina Caldari, Denison University
Mutations in Niemann-Pick C1 gene elicit different lipid storage, membrane composition and trafficking phenotypes
Hadeel Shammas, Hannover Medical School

Featured award lectures

Tony Hunter
Tony Hunter
Manajit Hayer-Hartl
Manajit Hayer-Hartl
Carol Fierke
Carol Fierke
Edward Dennis
Edward Dennis
Tyrosine phosphorylation — From discovery to drug development and beyond
Tony Hunter

Salk Institute for Biological Studies

Tang Prize in Biopharmaceutical Science
Saturday, April 4, 6 p.m.

Tony Hunter, PhD, from the Salk Institute for Biological Studies, is the British–American scientist who discovered tyrosine phosphorylation and that the oncogene Src is a tyrosine kinase (TK). This discovery is nothing less than saying Dr. Hunter gave birth to the field of tyrosine kinase inhibitors (TKIs), which are prototypes of targeted cancer therapies. Its emergence made a milestone of cancer therapy.

Cellular machineries devoted to rubisco — the most abundant enzyme
Manajit Hayer-Hartl

Max Planck Institute of Biochemistry

ASBMB–Merck Award
Sunday, April 5, 8:30 a.m.

Manajit Hayer–Hartl, a group leader at the Max-Planck Institute of Biochemistry, won the ASBMB–Merck Award, which recognizes outstanding contributions to research in biochemistry and molecular biology. Hayer-Hartl has led a research group focused on chaperonin-assisted protein folding research since 2006.

Toolbox to evaluate biological function of histone deacetylases
Carol Fierke

Texas A&M University

Mildred Cohn Award in Biological Chemistry
Monday, April 6, 8:30 a.m.

Carol Fierke, provost and executive vice president of Texas A&M University, won the Mildred Cohn Award in Biological Chemistry, which recognizes scientists who have made substantial advances in understanding biological chemistry using innovative physical approaches.

Enzyme hydrophobic sites and allosteric membrane interactions regulate signaling and mediators of inflammation
Edward Dennis

University of California, San Diego

Bert and Natalie Vallee Award in Biomedical Science lecture
Tuesday, April 7, 8:30 a.m.

Edward Dennis, a distinguished professor at the University of California, San Diego, won the Bert and Natalie Vallee Award in Biomedical Science. The award, established by the Bert and Natalie Kuggie Vallee Foundation in 2012, recognizes international achievements in the sciences basic to medicine. Dennis is a former chair of UCSD’s chemistry and biochemistry department and has led the faculty senate.