GTPase enzymes, important mediators of signaling, do not operate alone. This session presents three talks on how GTPases and their accessory proteins, GTPase activating proteins and guanine nucleotide exchange factors, or GAPS and GEFs, select substrates, remodel the cytoskeleton and contribute to cell migration.
The talks in this virtual event were originally programmed to take place as an in-person Spotlight Session at the 2020 ASBMB Annual Meeting.
Chair: Anjelika Gasilina
Examining the role of p190RhoGAP on the organization of the actin cytoskeleton in breast epithelial cells
Courtney Robinson, Saint Mary's College of California
The mechanism of actin remodeling by the BAR domain of ArfGAP ASAP1
Anjelika Gasilina, National Cancer Institute
A mitochondrial recruitment assay to characterize a family of DENN-domain proteins, Rab GDP/GTP exchange factors
Rahul Kumar, McGill University