This session presents an array of advances in glycobiology. Speakers share novel insights into how protein O-GlcNAcylation changes with statin treatment and during fetal development; how glycan-binding receptors affect tumor growth; and how cells that were once thought to make their own fucose can also scavenge it from their environments.
The talks in this virtual event were originally programmed to take place as an in-person Spotlight Session at the 2020 ASBMB Annual Meeting.
Chair: Paulina Sosicka
Novel insights into fucose metabolism — challenging the old dogma
Paulina Sosicka, Sanford-Burnham-Prebys Medical Discovery Institute
Molecular interaction of neuropilin-1 and 3-O-sulfated heparan sulfate modulates angiogenesis-dependent tumor growth
Chelsea Painter, University of California, San Diego
Pax2a regulates endothelial cell invasion into the optic fissure resulting in degradation of the basement membrane by mmp2
Megan Weaver, University of Kentucky
Fluvastatin decreases endothelial nitric oxide synthase O-GlcNAcylation by decreasing glucose uptake
Samantha Bohlman, University of Maryland
Linking maternal sugar consumption to progenies’ developmental defects: A focus on OTX2’s O-GlcNAcylation
Eugenia Wulff, Medical College of Wisconsin