Enzyme regulation by filamentation and other alternate and emerging mechanisms

May 27, 2020 | Duration: 2 hrs

Enzyme activity can be regulated through multiple mechanisms including localization and active-site orientation or accessibility. This virtual event focuses mainly on filamentation, a process by which enzymes reversibly self-assemble into linear structures. It also includes talks focused on other types of protein localization as well as alternative splicing to produce proteins with differing functions.

The talks in this virtual event were originally programmed to take place as an in-person Spotlight Session at the 2020 ASBMB Annual Meeting.


Chair: Nancy Horton

The filament forming mechanism of SgrAI endonuclease — structural and kinetic analysis
Nancy Horton, University of Arizona

Exploring structural determinants and functional aspects of micron-scale protein assemblies in living cells
Tal Levin, Weizman Institute

Identification of an actin-fold-containing metabolic enzyme that undergoes regulated polymerization
James Wilhelm, University of California, San Diego

Regulating ER protein homeostasis by differentially processing mRNAs
Weihan Li, Albert Einstein College of Medicine

Glycolysis enzymes coalesce in G bodies in hypoxia nucleated by RNA
Gregory Fuller, Johns Hopkins University

Filament formation enables highly cooperative regulation of human CTP synthase 2
Eric Lynch, University of Washington

Enzyme polymerization in nucleotide biosynthesis
Jeffrey Peterson, Fox Chase Cancer Center

Who should watch

  • Graduate students
  • Postdocs
  • Staff scientists
  • PIs
  • Biologists interested in emerging mechanisms of enzyme regulation

Key takeaways

Attendees will learn about emerging mechanisms of enzyme regulation.