Metabolism and bioenergetics
Cells use myriad mechanisms to adjust imbalances in redox state or ATP availability. Talks in this session describe studies using specialized technical approaches such as click chemistry and fluorescent sensors to probe the activity of enzymes involved in energetic homeostasis. Researchers discuss their investigation into spatial activity patterns of an AMP-responsive kinase; substrate selection by a histone deacylase that depends on redox state; and the protein acetylation signaling cascade that links oxidative stress with diabetic cardiomyopathy.
The talks in this virtual event were originally programmed to take place as an in-person Spotlight Session at the 2020 ASBMB Annual Meeting.
Chair: Danielle Schmitt
Illuminating spatiotemporal regulation of AMPK with a genetically encoded excitation-ratiometric biosensor for AMPK
Danielle Schmitt, University of California, San Diego
A click chemistry approach to reveal the chromatin-dependent histone H3 K36 deacetylase nature of SIRT7
Wenshe Liu, Texas A&M University
NAD redox imbalance drives diabetic cardiomyopathy: Roles of oxidative stress and post-translational modifications
Chi Fung Lee, Oklahoma Medical Research Foundation