Nucleic acid biology and biochemistry
This virtual event surveys a variety of new developments in nucleic acid research. The session includes talks on using biochemical methods to investigate questions related to nucleic acid biology: elucidating polymerase switching in bacteria through kinetic studies, visualizing intermediates in histone mRNA processing using NMR and determining the role that a pre-mRNA splicing protein plays in cardiogenesis using CRISPR/Cas9 and RNA-seq. The session also features talks on clinical applications of nucleic acid biochemistry, including the use of metatranscriptomics to detect infection in prosthetic joints and the use of nanolipoproteins to protect mRNA therapeutics from premature degradation in the cell.
The talks in this virtual event were originally programmed to take place as an in-person Spotlight Session at the 2020 ASBMB Annual Meeting.
Chair: Ying Liu
Synovial fluid sequencing: A look into the future of prosthetic joint infection detection
Lavinia Unverdorben, Juniata College
RNA-binding protein QKI is a critical pre-RNA splicing regulator for cardiac development and function
Ying Liu, Indiana University
Pre-steady state kinetic analysis of DnaE polymerase illuminates the limited (but essential) role it performs in gram-positive DNA replication
Sean Fagan, University at Albany
Histone mRNA uridylation: Oligo(U) tail, or stem-loop?
Patrick Lackey, Westminster College
Tailoring HDL mimetics for in vivo delivery of mRNA
Wei He, Lawrence Livermore National Laboratory
Image of 4TUX (Zhang, J., Tan, D., DeRose, E.F., Perera, L., Dominski, Z., Marzluff, W.F., Tong, L., Hall, T.M. (2014) Proc Natl Acad Sci U S A 111: E2937-E2946) created with the PyMOL Molecular Graphics System, Version 2.0 Schrödinger, LLC.