Lipid–protein interactions

July 2, 2020 | Duration: 1 hr. 15 mins.

What are the important roles of protein–lipid interactions? These ubiquitous macromolecules interact not only at the cell membranes, but in many locations in many different cell types. In this virtual session, researchers present their work on allosteric regulation of the interaction, binding specificities, structural requirements for binding, and how binding leads to protein–lipid signaling activation.

The talks in this virtual event were originally programmed to take place as an in-person Spotlight Session at the 2020 ASBMB Annual Meeting.


Chair: Michael Airola

Them1 binds to free fatty acids and is allosterically regulated by lysophosphatidylcholine to control fatty Acyl-CoA hydrolysis in brown adipose tissue
Matthew Tillman, Emory University

Re-defining the specificity of phosphoinositide-binding by human PH domain-containing proteins
Nilmani Singh, University of Illinois at Urbana-Champaign

Structural basis for the utilization of host fatty acids by bacterial fatty acid binding proteins
Jessica Gullett, St. Jude Children's Research Hospital

Crystal structure of the human phospholipase D1 catalytic domain provides insight into activation by PI(4,5)P2 and RhoA
Michael Airola, Stony Brook University