Glycosylation and extracellular matrix in neurologic and metabolic diseases

June 25, 2020 | Duration: 59 mins.

Extracellular matrix proteins can play an outsized role in tissue physiology. Talks in this session address how an extracellular protein in the kidney can contribute to inflammatory damage; how the length and composition of glycosylated proteins on adipose cells affect glucose homeostasis; and how changes to the extracellular matrix lattice in a brain network controlling blood glucose level can contribute to Type 2 diabetes.

The talks in this virtual event were originally programmed to take place as an in-person Spotlight Session at the 2020 ASBMB Annual Meeting.


Chair: Kimberly Alonge

Assembly of hypothalamic perineuronal nets contributes to sustained blood glucose lowering by FGF1 action in the brain
Kimberly Alonge, University of Washington Medicine Diabetes Institute

Adipose tissue heparan sulfate proteoglycans — Critical regulators of adipocyte metabolism and glucose homeostasis
Ariane Pessentheiner, University of California, San Diego

A TGFβ1-BIGH3-apoptosis axis comprising peptidase and integrin α3β1 promotes renal cell death
Richard LeBaron, University of Texas at San Antonio