Sept. 29 – Oct. 2, 2022 | Snowbird, Utah

Transcriptional Regulation

Chromatin and RNA Polymerase II

Transcriptional regulation: Chromatin and RNA polymerase II
Sept. 29 – Oct. 2, 2022 | Snowbird, Utah

Sessions will cover recent advances and new technologies in RNA polymerase II regulation, including the contributions of non-coding RNAs, enhancers and promoters, chromatin structure and post-translational modifications, molecular condensates, and other factors that regulate gene expression. Dr. Patrick Cramer of the Max Planck Institute will present the keynote address on the structure and function of transcription regulatory complexes.

The meeting is highly interactive and collaborative. Attendees will include principal investigators, postdoctoral fellows, students, and scientists from the pharmaceutical and biotech industries. Students and postdoctoral fellows are especially encouraged to attend and will be eligible for poster awards. Poster award winners will be given an opportunity to present their work as a short talk toward the end of the meeting.

Conference information

  • Conference will begin around 5 p.m. on Sept. 29.
  • Conference will conclude around 11 p.m. on Oct. 2.
  • If you choose a room with us during the registration process your check-in date will be Thursday, Sept. 29 and your check-out date will be Monday, Oct. 3. 
    • There are only a few rooms available at the venue and rooms will be assigned on a first come first served basis.​

Important dates

Aug. 28 Registration deadline


Karen Arndt
Karen Arndt
University of Pittsburgh
Dylan Taatjes
Dylan Taatjes
University of Colorado, Boulder
Yan Zhang
Yan Jessie Zhang
University of Texas at Austin

JBC virtual issue

RNA polymerase II and transcriptional regulation

A selection of articles published in the Journal of Biological Chemistry in recent years to showcase advances and new technologies in RNA polymerase II regulation.

Read the issue


Sponsorship opportunities

Become a sponsor of the ASBMB Transcriptional Regulation: Chromatin and RNA Polymerase II symposium. It’s the most effective way to reach key decision makers in the fields of transcription, chromatin biology, imaging, genomics and epigenetics.

See details of sponsorship levels and benefits

What’s included

The full conference package includes:

  • All scientific sessions, poster sessions and meeting materials.
  • 4 nights lodging at Snowbird Ski & Summer Resort (arriving Sept. 29, departing Oct. 3).
  • 1 complimentary tram ticket per attendee to use at their leisure during the meeting dates.

Note: Lodging is not included in commuter registration rates.

Registration changes

Registration changes will be accepted as space allows until Aug. 29, 2022, and can be made by contacting

Cancellation policy

Cancellations received in writing on or before Aug. 29, 2022, are subject to a $100 processing fee. No refunds will be issued for cancellations after Aug. 29, due to final guarantee commitments. Email and attach a copy of your meeting registration receipt/paid invoice.

Important health and safety information

  • As of Sept. 29, 2022, mask wearing is not required at the conference following local and state guidelines. We encourage attendees to wear a mask and should this policy change we will update attendees immediately via email.
  • Each attendee will receive one KN95 mask in their conference bag at badge pickup. 
  • All attendees are required to show a proof of vaccination when checking in at the conference badge pickup desk onsite at the meeting. Badges must be worn during the duration of the conference.
  • Registered attendees who do not show their proof of vaccination and don’t wear their badge will not be permitted to attend the meeting.
  • Accepted COVID-19 vaccines as defined by the CDC and WHO.
  • Vaccination proof accepted in forms of digital QR code, photo on phone, and physical copy of vaccination card.
  • Prior to checking in, at least 24 hours in advance of badge pickup, we encourage attendees to perform their own rapid antigen tests. You should alert ASBMB staff if you test positive and/or experience COVID-19 symptoms before checking in onsite at the badge pickup desk and refrain from attending the meeting.
  • Should you feel sick, show symptoms or test positive during the conference please alert ASBMB staff and refrain from attending the conference. 

Speaker instructions

  • Session room will be equipped with standard projection equipment which includes data projector, desktop computer and several adaptors — including HDMI cable, clicker, laser pointer — and a technician.
  • Check in with the AV tech in the room at least 30 minutes prior to the session your talk is in.
  • Bring your presentation on a readable USB flash drive. The AV tech will assist you in loading it onto the provided desktop computer.
  • Bring your laptop and HDMI cord or adapters if you want to give your talk with your own computer.
  • When preparing your presentation, please use standard fonts (e.g., Times New Roman, Arial, Helvetica, etc.). If you are using a font that is not standard it should be embedded into your PowerPoint presentation.
  • Create your presentation using 16:9 aspect ratio.
  • In the same folder as your presentation, include any external files that are used in the presentation, e.g. video files. Copy the entire folder to a USB flash drive.
  • Test your presentation on a separate laptop to ensure that the fonts are standard and that components such as movies are included rather than linked in your presentation.
  • Microphones in the session room are provided to ensure that everyone can clearly hear the presentations. Presenters should be mindful of those who are hard of hearing and always use the supplied microphones.
  • If you choose to present with your own laptop you must provide your own adapter to HDMI connections.

Poster presenters

  • Poster boards are 4’x8’ and the useable space is 45”x91”.
  • Push pins will be provided.
  • Poster presentations are scheduled on two days of the conference, Friday, Sept. 30, and Saturday, Oct. 1, from 8–10 p.m.
  • Set up your poster between 7–8 a.m. the morning of your scheduled poster presentation date.
  • Take down your poster at the conclusion of your poster presentation time slot.
  • Posters that are left up after your poster presentation session will be discarded.
  • Poster presentation dates and times cannot be switched.
NOTE: Poster prize winners are expected to give a short talk on Sunday evening of the conference. If you do not wish to participate in the poster competition or do not want to give a talk please email or stop by the badge pick-up desk on your presentation day to withdraw from the competition. 

Meeting location


Snowbird Ski & Summer Resort
Highway 210, Little Cottonwood Canyon
Snowbird, UT, 84092

All meeting sessions and events are scheduled in the Cliff Lodge, Entry #4.

Snowbird Resort is now cashless. All points of sale at Snowbird restaurants, retail stores, lodging properties, the spa, summer activities, parking and valet are cashless. Snowbird is accepting credit, debit and mobile pay only. Reverse ATMs are available at no charge and are located at the Snowbird Center on Level 1 next to Wings and on Level 2 in the Snowbird Center lounge along with The Cliff Lodge lobby. Prepaid debit cards from the Reverse ATMs are accepted anywhere, not just Snowbird.

What is Snowbird's elevation?

Snowbird’s base elevation, at the Snowbird Center, is 8,100 feet. Snowbird’s highest point is at Hidden Peak, where the tram docks — a whopping 11,000 feet.

Some tips for acclimating to the higher elevation: stay hydrated, consume foods rich in potassium, limit salt intake and give yourself a break from strenuous exercise until you've had a chance to adjust.

Oktoberfest at Snowbird

On our free afternoon, enjoy Oktoberfest activities. See the event description and map.

Getting to Snowbird

Closest airport

Salt Lake City International Airport (SLC) is approximately 40 minutes from Snowbird.

Airport shuttle service

It is the responsibility of each attendee to arrange for their transportation to the Snowbird resort from the airport and back to the airport from the Snowbird resort.

Canyon Transportation — provide your Snowbird housing confirmation when booking the shuttle.
800-453-3000 US toll free
00-800-4400-5511 International


From Salt Lake City International Airport

Take I-80 east to I-215 south. Take Exit 6 (6200 South) and go east on 6200 South, toward the mountains. This road will lead you straight to UT-210 and up Little Cottonwood Canyon to Snowbird.

From downtown Salt Lake City

Go west on 500 South to I-15 and head south. Exit at I-215 heading east. Get off at Exit 6 (6200 South) and go east on 6200 South, toward the mountains. This road will lead you straight to UT-210 and up Little Cottonwood Canyon to Snowbird.

From points South

Take I-15 north to Exit 295 (9000 South). Turn right onto 9000 South. This street becomes 9400 South, which takes you to the mouth of Little Cottonwood Canyon. Go right on UT-210. Six miles to Snowbird.

From Park City

Take UT-224 west and north to I-80. On I-80, head west toward the Salt Lake Valley. Take Exit 130 to I-215 south. Get off at Exit 6 (6200 South) and go east on 6200 South, toward the mountains. This road will lead you straight to UT-210 and up Little Cottonwood Canyon to Snowbird.

Program schedule

Thursday September 29
Friday September 30
Saturday October 1
Sunday October 2
Thursday September 26
Friday September 27
Saturday September 28
Sunday September 29

Thursday agenda

3:00 PM - 8:30 PM
Ballroom 3 lobby

Badge pickup

Badge pickup and session rooms are located on the lower level L1 of the cliff lodge.
5:00 PM - 6:15 PM


Attendees are required to pick up their badge prior to attending dinner. You cannot attend dinner without your badge. Primrose is located on the lobbly level L right by the resort checkin. 
6:30 PM - 6:45 PM

Welcome and opening remarks by organizers

6:45 PM - 8:15 PM

Session I: Structure/function of transcription complexes

Session chair: Catherine Musselman

Structural basis of nucleosome retention during transcription
Lucas Farnung, Harvard Medical School
Single molecule analysis of RNApII transcription reveals unexpected features of transcription activation and PIC assembly
Stephen Buratowski, Harvard Medical School
Regulating transcription by chromatin-bound PP2A
Alessandro Gardini, Wistar Institute
Mechanism of the INO80 ATP-dependent chromatin remodeling complex
Geeta Narlikar, University of California, San Francisco
CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site
Xin Liu, University of Texas Southwestern Medical Center
8:30 PM - 10:30 PM

Welcome networking reception

Attendees are required to pick up their badge prior to attending the reception. You cannot attend the reception without your badge.

Friday agenda

7:00 AM - 12:00 PM
Ballroom 3 lobby

Badge pickup

Badge pickup and session rooms are located on the lower level L1 of the cliff lodge.
7:00 AM - 8:15 AM


8:30 AM - 10:00 AM

Session II: Transcription factors

Session chair: Peter Verrijzer

Mechanisms and impact of transcription factor interactions with nucleosomes
Ken Zaret, University of Pennsylvania
Genome-wide functions of yeast DNA sequence-specific transcription factors
Steven Hahn, Fred Hutchinson Cancer Center
Histone modifications regulate pioneer transcription factor binding and cooperativity
Mario Halic, St. Jude Children’s Research Hospital
The oncogenic transcription factor ERG utilizes distinct positive feedback loops to mediate diverse cell fates
Peter Hollenhorst, Indiana University
Mechanism underlying binding selectivity of pioneer factors
Lu Bai, Pennsylvania State University
10:00 AM - 10:55 AM

Networking break

10:55 AM - 12:30 PM

Session III: Transcription initiation

Session chair: Shannon Lauberth

Mechanistic studies of TFIIH kinase CDK7 reveal regulatory roles at multiple transcriptional stages
Dylan Taatjes, University of Colorado Boulder
Mechanisms of RNA Polymerase II transcription
Craig Kaplan, University of Pittsburgh
RNA Polymerase II pausing coordinates stage-selective cell cycle progression and erythroid differentiation
Stirling Churchman, Harvard Medical School
In vivo contribution of the DPE core promoter motif to transcriptional regulation in developing Drosophila melanogaster embryos
Tamar Juven–Gershon, Bar-Ilan University
Distinct architectures of induced, poised and constitutive yeast promoters reveal an integrated SAGA and TFIID PIC assembly pathway during induction
Frank Pugh, Cornell University
12:30 PM - 1:45 PM


2:00 PM - 3:30 PM

Session IV: RNA Pol II and post-translational modifications

Session chair: Stirling Churchman

Chemical approaches to understanding reversible lysine modifications
Philip Cole, Harvard Medical School
New insights into the mono-ADP-ribosyltransferase function of SIRT6
Katharine Diehl, University of Utah
Spatiotemporal recruitment of transcription regulators by the post-translational modifications on RNA Polymerase II
Y. Jessie Zhang, University of Texas at Austin
Co-evolution of the Ess1-CTD axis in polar fungi suggests a role for phase separation in cold tolerance
Steven Hanes, SUNY Upstate Medical University
An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability
Brian Strahl, University of North Carolina
3:30 PM - 4:05 PM

Networking break

4:05 PM - 5:55 PM

Session V: Transcription elongation

Session chair: Lucas Farnung

Probing the direct effects of the Paf1 complex on transcription and chromatin
Karen Arndt, University of Pittsburgh
RNA modifications in R-loops regulate the pausing of elongating RNA Polymerase II in non-coding RNA
Jason Watts, National Institute of Environmental Health Sciences
An optimal Pol II position for co-transcriptional splicing restricts gene output when splicing is less efficient
Karla Neugebauer, Yale University
Molecular basis of transcription blockage, transcription-couples damage recognition and repair
Dong Wang, University of California, San Diego
The roles of FACT during transcription elongation
Francois Robert, IRCM
6:30 PM - 7:45 PM


8:00 PM - 10:00 PM

Poster session I & reception

Saturday agenda

7:00 AM - 12:00 PM
Ballroom 3 lobby

Badge pickup

Badge pickup and session rooms are located on the lower level L1 of the cliff lodge.
7:00 AM - 8:15 AM


8:30 AM - 9:15 AM

Keynote lecture

Mechanisms of chromatin transcription
Patrick Cramer, Max Planck Institute for Multidisciplinary Sciences
9:15 AM - 10:20 AM

Session VI: Enhancers

Session chair: Allesandro Gardini

Architecture, identification and functional features of active human enhancers
John Lis, Cornell University
SWI/SNF and its AT-hook is required for de novo enhancer activation in cell lineage priming
Blaine Bartholomew, M.D. Anderson Cancer Research Center
Hormone-induced enhancer assembly requires an optimal level of multivalent interactions
Zhijie "Jason" Liu, University of Texas Health Science Center at San Antonio
Nucleation and spreading rejuvenate polycomb domains every cell cycle
Srinivas Ramachandran, University of Colorado School of Medicine
Role of enhancer RNAs in the estrogen-regulated control of enhancer assembly and function in breast cancer cells
W. Lee Kraus, University of Texas Southwestern Medical Center
10:20 AM - 10:50 AM

Networking break

10:50 AM - 12:20 PM

Session VII: Structure/function of transcription complexes II

Session chair: Courtney Hodges

Nucleosome assembly disassembly, and stacking
Karolin Luger, University of Colorado Boulder
Swi-Snf represses sulfur metabolism gene transcription by promoting cysteine biosynthesis
Michael Church, Stowers Institute for Medical Research
Nucleosome conformation dictates the histone code
Catherine Musselman, University of Colorado Anschutz Medical Campus
Structure and function of a bacterial histone lysine methyltransferase in pathogenesis
Raymond Trievel, University of Michigan
What a double-headed histone methyl transferase enzyme can teach us about writing and reading gene repressive marks on chromatin
Bassem Al-Sady, University of California, San Francisco
12:35 PM - 6:30 PM

Lunch on own with free time to explore Snowbird

4:00 PM - 5:00 PM


Space is on a first come, first served basis due to limited yoga mats available and is complimentary for registered conference attendees. Attendees are required to sign a liability form prior to attending. Conference badge required.
6:30 PM - 7:45 PM


8:00 PM - 10:00 PM

Poster session II & reception

Sunday agenda

7:00 AM - 8:15 AM


8:30 AM - 10:20 AM

Session VIII: Chromatin, Pol II and non-coding RNA

Session chair: Laura Banaszynski

The pausing zone, the torpedo and control of RNA Polymerase II elongation and termination
David Bentley, University of Colorado School of Medicine
The lncRNA Firre functions as a transcriptional activator
John Rinn, University of Colorado Boulder
Exploration of the regulation of transcription by RNA Polymerase II
James Kadonaga, University of California, San Diego
Competition for H2A.Z between genes and repetitive elements establishes transcriptional response to anti-viral immune activation
Patrick Murphy, University of Rochester
Analysis of the human Ccr4-Not complex
Joseph Reese, Pennsylvania State University
Role of enhancer RNAs in the estrogen-regulated control of enhancer assembly and function in breast cancer cells
W. Lee Kraus, University of Texas Southwestern Medical Center
10:20 AM - 10:40 AM

Networking break

10:40 AM - 12:25 PM

Session IX: Imaging and emerging techniques

Session chair: Benjamin Sabari

Single-molecule dynamics of chromatin remodelers and transcription factors
Carl Wu, John Hopkins University
Multifactorial chromatin regulatory landscapes at single cell resolution in development
Michael Meers, Washington University School of Medicine St. Louis
Connecting transcriptional regulation to transcription factor dynamics: MYC, bursting and kinetic proofreading
Daniel Larson, National Cancer Institute
Development of a novel class of epigenetic sensors for cut&run
Bryan Venters, EpiCypher
Super-resolution imaging of transcription in live mammalian cells
Ibrahim Cissé, Max Planck Institute
Single-molecule and single-cell epigenetics: Decoding the epigenome for cancer research and diagnostics
Efrat Shema, Weizmann Institute of Science
12:30 PM - 1:45 PM


2:00 PM - 3:35 PM

Session X: Chromatin organization and partitioning

Session chair: Katharine Diehl

The role of noncoding RNAs in cancer: shedding light on the transcriptomic dark matter
Shannon Lauberth, Northwestern University
Functional partitioning of transcriptional regulators by patterned charge blocks
Benjamin Sabari, University of Texas Southwestern Medical Center
Circadian transcription factors rhythmically regulate stereotypic chromatin conformations at enhancers
Jerome Menet, Texas A&M University
Investigating the methyl-CpG binding protein ZBTB4 in mediating epigenetic-based transcriptional processes
Bethany Buck–Koehntop, University of Utah
Dosage matters: Regulation, dynamics and consequences of histone H2A ubiquitylation
Peter Verrijzer, Erasmus University Rotterdam
3:35 PM - 3:55 PM

Networking break

3:55 PM - 5:20 PM

Session XI: Genome architecture

Session chair: Srinivas Ramachandran

Effects of histone H2B ubiquitylations and H3K79 tri-methylation on the kinetics of transcription through the nucleosome investigated with single-molecule FRET
Tae-Hee Lee, Pennsylvania State University
Global repression and variable compensation following inhibition of mammalian SWI/SNF
Benjamin Martin, Harvard Medical School
Loss of heterochromatin at endogenous retroviruses creates competition for transcription factor binding
Laura Banaszynski, University of Texas Southwestern Medical Center
Dynamic chromatin conformations underlie transcriptional coupling of distant regulatory genes in living embryos
Michal Levo, Princeton University
Dynamic reactivation of the G1 enhancer landscape underlies SWI/SNF addiction
H. Courtney Hodges, Baylor College of Medicine
5:30 PM - 6:45 PM


7:00 PM - 7:10 PM

Poster prize winners announced

7:10 PM - 7:45 PM

Poster prize oral presentations

7:45 PM - 8:45 PM

Session XII: Disease and therapeutics

Session chair: Jason Watts

Integrated single-cell multiomic analysis of HIV latency reversal reveals novel regulators of viral reactivation
Edward Browne, University of North Carolina School of Medicine
CDK12 regulates nucleolar organization in cancer cells
Rani George, Harvard Medical School
Principles of epigenetics and chromatin in development and human disease
Ali Shilatifard, Northwestern University
8:45 PM - 9:00 PM

Closing remarks by organizers

9:00 PM - 11:00 PM

Closing networking reception

Thursday agenda

6:30 PM - 7:00 PM

Opening remarks & Keynote lecture I

7:00 PM - 9:00 PM

Session I: Transcription initiation

Friday agenda

8:30 AM - 10:30 AM

Session II: Transcription initiation

10:30 AM - 12:30 PM

Session III: Post-translational modification

2:00 PM - 4:00 PM

Session IV: Imaging

4:00 PM - 6:00 PM

Session V: Enhancers

8:00 PM - 10:00 PM

Poster session I

Saturday agenda

8:30 AM - 10:30 AM

Session VI: Transcription elongation

10:30 AM - 12:30 PM

Session VII: Transcription complex structure function

12:30 PM - 8:00 PM

Free afternoon

8:00 PM - 10:00 PM

Poster session II

Sunday agenda

8:30 AM - 10:30 AM

Session VIII: Transcription termination

10:30 AM - 12:30 PM

Session IX: Chromatin and organization

2:00 PM - 4:00 PM

Session X: Non-coding RNA

4:00 PM - 5:30 PM

Session XI: Genome architecture

7:00 PM - 8:00 PM

Keynote lecture II & Poster award presentation

8:00 PM - 10:00 PM

Session XII: Diseases and therapeutics

Sign up for email updates

Enter your email address below to receive updates about the Transcriptional regulation: Chromatin and RNA polymerase II conference.