Oct. 28–30, 2021 | Virtual

Serine Proteases

in Pericellular Proteolysis and Signaling

Serine proteases in pericellular proteolysis and signaling
Oct. 28–30, 2021 | Virtual | Paid registration required

The virtual meeting on Serine Proteases in Pericellular Proteolysis and Signaling continues the tradition of the ASBMB special symposium on membrane-anchored serine proteases with an expanded focus on other related proteases with overlapping substrates and functions in the pericellular environment.

The conference traditionally brings together the leading national and international researchers in the field of pericellular proteolysis and provide them with a forum to present their latest findings, exchange ideas and technologies, and network to form collaborations. Equally important, it also provides a venue for junior investigators at the graduate student and postdoctoral level to discuss their current research, meet with experts in the field and forge new scientific interactions crucial for their future career development. To this end, we plan an interactive poster session and easy access to poster presenters' video recordings to increase the visibility of their work. Holding the meeting virtually provides a unique opportunity to make this conference even more accessible to students as well as to investigators from other fields where pericellular proteolysis is implicated.

Topics covered

Cleavage of proteins in the extracellular environment, including hormones, growth factors and their receptors, ion channels, cell adhesion molecules and structural components of extracellular matrix, plays a key role in the regulation of cell behavior. Among more than 500 proteolytic enzymes encoded by mammalian genomes, membrane-anchored serine proteases, which are expressed on the cell surface in all major organs, are excellently suited to mediate signal transduction across the plasma membrane and are increasingly being recognized as important regulators of organ development and homeostasis. At the same time, unrestrained pericellular proteolysis has been shown to contribute to epithelial and endothelial barrier dysfunction, inflammatory, cardiovascular, and respiratory diseases, as well as cancer. Many of the influenza- and coronavirus-type viruses, including SARS-CoV-2, are now known to also use activity of these proteases to gain entry into the target cell, making MASPs a major determinant of cell susceptibility to infection.

In addition to the roles of serine proteases in viral biology, the meeting will cover topics including biosynthesis, trafficking and post-translational modifications, endogenous and pharmacological inhibitors, developmental and other physiological functions, mechanisms of dysregulation and pathological consequences, and molecular mechanisms of protease-mediated signaling.

Important dates

Sept. 30 Early registration deadline
Oct. 27 Regular registration deadline

Organizers

Daniel Kirchhofer
Daniel Kirchhofer
Genentech Inc.
Suzanne Jackowski
Roman Szabo
National Institute of Dental and Craniofacial Research, NIH

Sponsors

Registration

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Registration type Early registration
(on/before Sept. 29)
Full-price registration
(Oct. 1–27)
Members Nonmembers Members Nonmembers
Regular/Industry $200 $225 $225 $250
Early-career $50 $75 $60 $85
Graduate/Undergraduate student $25 $50 $25 $50
Affiliate $25 $50 $35 $60
Emeritus member $112 -- $137 --

Program schedule

All times listed are U.S. Eastern Daylight Time (GMT-4)

Thursday October 28
Friday October 29
Saturday October 30

Thursday agenda

10:00 AM - 12:15 PM

Session 1: Proteases in viral biology

Proteolytic activation of SARS-CoV-2 and its inhibition
Stefan Poehlman, German Primate Institute
TMPRSS2 is the major activating protease of influenza A virus of different HA-subtype in murine and human airways and influenza B virus in human lung 
Hannah Limburg, Marburg University
Type II transmembrane serine proteases inhibitors prevent SARS-CoV-2 infection
Sébastien Dion, Université de Sherbrooke
Implications of Spike-glycoprotein processing at S1/S2 by Furin, at S2’ by Furin and/or TMPRSS2 and shedding of ACE2: Cell-to-cell fusion, cell entry and infectivity of SARS-CoV-2
Nabil Seidah, Clinical Research Institute of Montreal
12:35 PM - 2:15 PM

Session 2: Development and physiology

What is new about the proteolytic activation of ENaC by proteases in the kidney?
Edith Hummler-Beermann, University of Lausanne
Qingyu Wu, Soochow University
Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice
Ferruh Artunc, University Hospital Tuebingen
Par2 is one of several targets for deregulated matriptase activity in Hai-1-deficient embryos and mice
Eric Camerer, Inserm
2:35 PM - 4:00 PM

Session 3: Inflammation and immunity

Celine Deraison, Digestive Health Research Institute
Plasminogen Deficiency Leads to Periodontitis Susceptibility
Lakmali Silva, National Institutes of Health

Friday agenda

9:55 AM - 12:20 PM

Session 4: Biosynthesis, structure and cellular regulation

Activation, inhibition and deregulation of the matriptase pathway
Lotte Vogel, University of Copenhagen
Hepatocyte growth factor activator inhibitor-1 (HAI-1)/SPINT1 of cancer cells: Friend or foe in invasive growth?
Hiroaki Kataoka, University of Miyazaki
The ectodomain of matriptase-2 plays an important non-proteolytic role in suppressing hepcidin expression in mice
An-Sheng Zhang, Oregon Health Sciences University
12:20 PM - 2:50 PM

Session 5: Cancer development and progression

Global protease activity profiling identifies HER2-driven proteolysis in breast cancer
Charles Craik, University of California, San Francisco
Matriptase activation via hypotonic stress and polarity defects induces epidermal tumors through PI3K-Akt-mTORC1-NFkB in zebrafish
Julia Hatzold, University of Cologne
Membrane serine proteases in hemostasis and cancer
Toni Antalis, University of Maryland School of Medicine
Cell-surface serine proteases as tumor promoters or tumor suppressors
Karin List, Wayne State University School of Medicine
Stage-dependent functions of dipeptidyl peptidase 9 in mammary cancer progression
Lisa Hess,
Novel activities of the GPI-anchored serine protease testisin in the regulation of coagulation and fibrinolysis
Marguerite Buzza, University of Maryland

Saturday agenda

9:55 AM - 12:00 PM

Session 6: Development of tools for imaging and diagnosis

Kallikrein 5 inhibition by the lympho-epithelial kazal-type related inhibitor hinders matriptase-dependent carcinogenesis
Katiuchia Sales, Ribeirao Preto Medical School
Imaging of protease activity using recombinant Probody therapeutics
Olga Vasilieva,
Uncovering the dynamics of proteolytic activity in human milk
Anthony O'Donoghue, University of California, San Diego
Design of selective active-based probes for imaging of proteases in coagulation pathway
Marcin Drag, Wroclaw University of Science and Technology
In vivo measurement of granzyme proteolysis from activated immune cells with PET
Conner Bardine, University of California, San Francisco
12:20 PM - 2:50 PM

Session 7: Targeting protease activity in human disease

Inhibition of β-tryptase for severe asthma by antibodies with distinct allosteric mechanisms of action
Bob Lazarus, Genentech Inc.
Engineering complement factor I as a protease medicine: Tuning potency and specificity for complement-mediated disorders
Grant Blouse, Catalyst Biosciences
Covalent TMPRSS2 and matriptase inhibitors as antiviral and anticancer agents
James Janetka, Washington University School of Medicine
Allosteric inhibition of HtrA1 activity by a conformational "lock" mechanism to treat age-related macular degeneration
Stefan Gerhardy, Genentech Inc.
Generation and characterisation of KY1066, a fully human antibody targeting the enzymatic activity of matriptase-2 for the treatment of iron overload in β-thalassemia
Anais Palin, Inserm
Hepsin regulates TGFβ signaling via fibronectin proteolysis
Denis Belitskin, University of Helsinki

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