Oct. 28–30, 2021 | Virtual

Serine Proteases

in Pericellular Proteolysis and Signaling

Serine proteases in pericellular proteolysis and signaling
Oct. 28–30, 2021 | Virtual

The 2021 ASBMB virtual meeting on Serine Proteases in Pericellular Proteolysis and Signaling continues the tradition of the special symposia on membrane-anchored serine proteases (MASPs) with an expanded focus on other related proteases with overlapping substrates and functions in the pericellular environment. Due to the COVID-19 pandemic, this year's program will be offered virtually, hosted by the ASBMB.

The conference traditionally brings together the leading national and international researchers in the field of pericellular proteolysis and provide them with a forum to present their latest findings, exchange ideas and technologies, and network to form collaborations. Equally important, it also provides a venue for junior investigators at the graduate student and postdoctoral level to discuss their current research, meet with experts in the field and forge new scientific interactions crucial for their future career development. To this end, we plan an interactive poster session and easy access to poster presenters' video recordings to increase the visibility of their work. Holding the meeting virtually provides a unique opportunity to make this conference even more accessible to students as well as to investigators from other fields where pericellular proteolysis is implicated.

Topics covered

Cleavage of proteins in the extracellular environment, including hormones, growth factors and their receptors, ion channels, cell adhesion molecules and structural components of extracellular matrix, plays a key role in the regulation of cell behavior. Among more than 500 proteolytic enzymes encoded by mammalian genomes, membrane-anchored serine proteases, which are expressed on the cell surface in all major organs, are excellently suited to mediate signal transduction across the plasma membrane and are increasingly being recognized as important regulators of organ development and homeostasis. At the same time, unrestrained pericellular proteolysis has been shown to contribute to epithelial and endothelial barrier dysfunction, inflammatory, cardiovascular, and respiratory diseases, as well as cancer. Many of the influenza- and coronavirus-type viruses, including SARS-CoV-2, are now known to also use activity of these proteases to gain entry into the target cell, making MASPs a major determinant of cell susceptibility to infection.

In addition to the roles of serine proteases in viral biology, the meeting will cover topics including biosynthesis, trafficking and posttranslational modifications, endogenous and pharmacological inhibitors, developmental and other physiological functions, mechanisms of dysregulation and pathological consequences, and molecular mechanisms of protease-mediated signaling.

Important dates

May 15 Registration and abstract submission site opens
Sept. 1 Abstract submission deadline
Sept. 30 Early registration deadline
Oct. 27 Regular registration deadline

Organizers

Daniel Kirchhofer
Daniel Kirchhofer
Genentech Inc.
Suzanne Jackowski
Roman Szabo
National Institute of Dental and Craniofacial Research, NIH

Speakers

Proteolytic activation of SARS-CoV-2 and its inhibition
Stefan Pöhlman, Leibniz Institute for Primate Research

Hepatocyte growth factor activator inhibitor-1 (HAI-1)/SPINT1 of cancer cells: friend or foe in invasive growth?
Hiroaki Kataoka, University of Miyazaki

Protease function in uterine spiral artery remodeling
Qingyu Wu, Cleveland Clinic Lerner Research Institute

Novel mechanisms of inhibition of b-tryptase by antibodies
Robert Lazarus, Genentech

What is new about the proteolytic activation of ENaC by proteases in the kidney?
Edith Hummler-Beermann, University of Lausanne

Activation, inhibition and deregulation of the matriptase pathway
Lotte Vogel, University of Copenhagen

Type II transmembrane serine proteases inhibitors prevent SARS-CoV-2 infection
Sabastien Dion, Université de Sherbrooke

Cell-surface serine proteases as tumor promoters or tumor suppressors
Karin List, Wayne State University School of Medicine

Membrane serine proteases in hemostasis and cancer
Toni Antalis, University of Maryland School of Medicine

Imaging of protease activity using recombinant probody therapeutics
Olga Vasilieva, CytomX Therapeutics

Covalent TMPRSS2 and matriptase inhibitors as antiviral and anticancer agents
James Janetka, Washington University in St. Louis

Global protease activity profiling identifies HER2-driven proteolysis in breast cancer
Charles Craik, University of California, San Francisco School of Pharmacy

Uncovering the dynamics of proteolytic activity in human milk
Anthony O'Donoghue, University of California, San Diego

Design of selective active-based probes for imaging of proteases in coagulation pathway
Marcin Drag, Wroclaw University of Technology

Sponsors

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