Serine Proteases in Pericellular Proteolysis and Signaling
September 12–15, 2019
Eric Camerer, INSERM
Bob Lazarus, Genentech, Inc.
The 2019 symposium on Serine Proteases in Pericellular Proteolysis and Signaling continues the tradition of the special symposia on membrane-anchored serine proteases with an expanded focus on other serine proteases with overlapping substrates and functions in the pericellular environment.
Proteases account for approximately 2% of mammalian proteome. A subset of these in the serine protease superfamily are actively involved in coordinating organ development and cellular behavior through proteolytic processing of hormones, growth factors, membrane receptors and ion channels. While some, such as the membrane-anchored serine proteases (MASPs), contain transmembrane domains or lipid anchors, others make use of plasma membrane cofactors and other mechanisms to direct their activities to the pericellular environment. Pericellular proteolysis is important for organ development and homeostasis but can also contribute to epithelial and endothelial barrier dysfunction, inflammatory disease, cancer, cardiovascular disease and neurodegenerative diseases if protease activities are not adequately restrained. Understanding the biochemistry and biology of these proteases and their regulators is therefore of great interest to basic science, clinical research and drug development.
Session 1: Development and Physiology
Discussion leaders: Karin List and Leonard Drees
Session 2: Molecular tools for imaging, diagnosis and targeting in health and disease
Discussion leaders: Daniel Kirchhofer and Swapnil Ghodge
Session 3: Biosynthesis, trafficking, structure and cellular regulation
Discussion leaders: Ningzheng Dong and Kaitlin Hulce
Session 4: Cancer
Discussion leaders: Toni Antalis and Topi Tervonen
Session 5: Inflammation, host defense and infection
Discussion leaders: Thomas Bugge and Nisha Pawar