May 4–5, 2021 | Virtual

PDB50

A special symposium celebrating the 50th anniversary of the Protein Data Bank

May 4–5, 2021

PDB50 will mark an important milestone in the history of structural biology. In 1971, the structural biology community established the single worldwide archive for macromolecular structure data — the Protein Data Bank (PDB). From its inception, the PDB has embraced a culture of open access, leading to its widespread use by the research community. PDB data are used by hundreds of data resources and millions of users exploring fundamental biology, energy and biomedicine.

Structural biology and structural bioinformatics have had an enormous impact on our understanding of the mechanism and function of biological macromolecules. The PDB acts as a custodian for all these data, representing a repository of the vast majority of the achievements and milestones of the structural biology community. The archive is managed by the Worldwide Protein Data Bank consortium (wwPDB) of partner sites in Asia, Europe and America.

This celebration of the 50th anniversary of the founding of the Protein Data Bank as the first open access digital data resource in biology will include presentations from speakers from around the world who have made tremendous advances in structural biology and bioinformatics. Students and postdoctoral fellows are especially encouraged to attend and will be eligible for poster prizes.

Early and late stage career scientists are encouraged to submit an abstract for poster presentation during the symposium.

The online sessions will take place between 11 a.m. – 4:30 p.m. EDT each day.

The event will be recorded and made available to registered participants after the meeting.

Important dates

May 1
11:59 p.m. PDT
Registration deadline

Speakers

Eddy Arnold

Eddy Arnold

  • Rutgers, The State University of New Jersey
  • Using HIV-1 reverse transcriptase structures to guide anti-AIDS drug discovery
Helen M. Berman

Helen M. Berman

  • Rutgers, The State University of New Jersey
  • University of Southern California
  • The evolution of the Protein Data Bank as a community resource
Thomas L. Blundell

Thomas L. Blundell

  • University of Cambridge
  • A personal history of five decades of structural biology and the PDB: From the X-ray structure of 2-Zinc insulin hexamer in 1970 to Cryo-EM structures of DNA-PK from DNA repair in 2020
Alexandre M. J. J. Bonvin

Alexandre M. J. J. Bonvin

  • Utrecht University
  • Solving 3D puzzles by integrative modelling using PDB structures
Stephen K. Burley

Stephen K. Burley

  • Rutgers, The State University of New Jersey
  • University of California, San Diego
  • Impact of structural biologists and fifty years of Protein Data Bank operations on drug discovery and development
Wah Chiu

Wah Chiu

  • Stanford University
  • Cryo-EM of biomolecules at Ångström resolutions
Johann Deisenhofer

Johann Deisenhofer

  • University of Texas Southwestern Medical Center
  • 50 years of PDB — from crazy idea to treasure
Juli Feigon

Juli Feigon

  • University of California, Los Angeles
  • Structural biology of telomerase
Angela M. Gronenborn

Angela M. Gronenborn

  • University of Pittsburgh
  • Integrated BioNMR — getting by with a little help from my friends
Jennifer L. Martin

Jennifer L. Martin

  • University of Wollongong
  • Science, crystallography, reflections: A journey with the PDB over 35 years
Stephen L. Mayo

Stephen L. Mayo

  • California Institute of Technology
  • Antibody small molecule conjugates with computationally designed target binding synergy
Zihe Rao

Zihe Rao

  • ShanghaiTech University
  • Tsinghua University
  • Structural insight into SARS-CoV-2 replication and transcription complex (RTC)
Hao Wu

Hao Wu

  • Harvard Medical School
  • Boston Children's Hospital
  • "Speck"tacular inflammasomes: structures of supramolecular complexes in innate immunity
PDB50

Organizers

  • Celia Schiffer, University of Massachusetts Medical School
  • Helen M. Berman, Rutgers, The State University of New Jersey; RCSB PDB
  • Stephen K. Burley, Rutgers, The State University of New Jersey; RCSB PDB
  • Jeffrey C. Hoch, University of Connecticut; BMRB
  • Gerard J. Kleywegt, European Bioinformatics Institute; PDBe
  • Genji Kurisu, Osaka University; PDBj
  • John L. Markley, University of Wisconsin–Madison; BMRB
  • Sameer Velankar, European Bioinformatics Institute; PDBe
  • Christine Zardecki, Rutgers, The State University of New Jersey; RCSB PDB

Acknowledgement: Illustration by David S. Goodsell, The Scripps Research Institute. doi: 10.2210/rcsb_pdb/goodsell-gallery-003

This illustration shows a cross-section through the blood, with blood serum in the upper half and a red blood cell in the lower half. In the serum, look for Y-shaped antibodies, long thin fibrinogen molecules (in light red) and many small albumin proteins. The large UFO-shaped objects are low density lipoprotein and the six-armed protein is complement C1. The red blood cell is filled with hemoglobin, in red. The cell membrane, in purple, is braced on the inner surface by long spectrin chains connected at one end to a small segment of actin filament.

Journals

JBC celebrates the Protein Data Bank

JBC celebrates the Protein Data Bank

The Journal of Biological Chemistry has assembled a thematic review series and virtual collection of papers commemorating the PDB's 50th anniversary.

Event

Celebrating the Protein Data Bank

Celebrating the Protein Data Bank

A two-day virtual event will highlight the science preserved within and enabled by the resource over the past 50 years. We talked to PDB co-founder Helen Berman about what attendees can expect.

Sponsorships

Thank you PDB50 sponsors!

Sponsorship opportunities are still available; contact the wwPDB Foundation for more information.

Program schedule

All times listed are U.S. Eastern Daylight Time (EDT)

Tuesday May 4
Wednesday May 5

Tuesday agenda

11:00 AM - 1:00 PM

PDB50 Scientific Session #1

Welcome to PDB50 — A Celebration!
by Celia Schiffer, University of Massachusetts Medical Center

Moderator: Janet Thornton, European Bioinformatics Institute

The evolution of the Protein Data Bank as a community resource
Helen M. Berman, Rutgers, The State University of New Jersey; University of Southern California
Structural insight into SARS-CoV-2 replication and transcription complex (RTC)
Zihe Rao, Shanghai Tech University; Tsinghua University
Impact of structural biologists and fifty years of Protein Data Bank operations on drug discovery and development
Stephen K. Burley, Rutgers, The State University of New Jersey; University of California, San Diego
Solving 3D puzzles by integrative modelling using PDB structures
Alexandre M. J. J. Bonvin, Utrecht University
1:00 PM - 3:00 PM

Posters/Exhibits/Virtual lounge

3:00 PM - 4:30 PM

PDB50 Scientific Session #2

Moderator: Thomas Koetzle, Brookhaven National Laboratory

Using HIV-1 reverse transcriptase structures to guide anti-AIDS drug discovery
Eddy Arnold, Rutgers, The State University of New Jersey
"Speck"tacular inflammasomes: structures of supramolecular complexes in innate immunity
Hao Wu, Harvard Medical School; Boston Children's Hospital
Science, crystallography, reflections: A journey with the PDB over 35 years
Jennifer L. Martin, University of Wollongong

Wednesday agenda

11:30 AM - 1:00 PM

PDB50 Scientific Session #3

Welcome Back – Celia Schiffer, University of Massachusetts Medical Center

Moderator: Joel Sussman, Weizmann Institute of Science

50 years of PDB — from crazy idea to treasure
Johann Deisenhofer, University of Texas Southwestern Medical Center
Structural biology of telomerase
Juli Feigon, University of California, Los Angeles
A personal history of five decades of structural biology and the PDB: From the X-ray structure of 2-Zinc insulin hexamer in 1970 to Cryo-EM structures of DNA-PK from DNA repair in 2020
Thomas L. Blundell, University of Cambridge
1:00 PM - 3:00 PM

Posters/Exhibits/Virtual lounge

3:00 PM - 4:30 PM

PDB50 Scientific Session #4, Poster Award Announcement and Closing Remarks

Moderator: Shoshana Wodak, SickKids Research Institute

Antibody small molecule conjugates with computationally designed target binding synergy
Stephen L. Mayo, California Institute of Technology
Cryo-EM of biomolecules at Ångström resolutions
Wah Chiu, Stanford University
Integrated BioNMR — getting by with a little help from my friends
Angela M. Gronenborn, University of Pittsburgh

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