July 7–10, 2022 | Athens, Ga.

O-GlcNAc

regulation of cellular physiology and pathophysiology

O-GlcNAc regulation of cellular physiology and pathophysiology
July 7–10, 2022 | University of Georgia, Athens, Ga.

This conference will address the multitude of roles that the O-GlcNAc protein modification has in regulating nuclear and cytosolic proteins. It will bring together researchers from diverse fields to share their research, tools and experience in O-GlcNAc biology.

O-GlcNAc continues to be an underappreciated post-translational modification. However, the combination of advancements in determining protein-specific function and discovery that the modification is linked to many diseases have led to its recognition as an emerging target for understanding both normal and pathological processes in the cell.

The meeting will draw experts in O-GlcNAc biology from around the world to discuss how O-GlcNAc and O-GlcNAc cycling enzymes modulate protein function in basic biological processes as well as in disease states, including diabetes, cancer, cardiovascular disease and neurological diseases.

Graduate students and postdoctoral fellows, established in or wishing to learn about the field, are encouraged to attend and submit abstracts. The organizers will select oral presenters, and there will be a poster session.

Important dates

May 23 Poster abstract deadline
June 6 Regular registration deadline

COVID-19 vaccine requirement

For the health and safety of attendees, ASBMB/O-GlcNAc regulation of cellular physiology and pathophysiology is requiring COVID-19 vaccines for anyone attending this conference. Mask-wearing and other requirements will be taken into consideration based on state and local guidelines and will be communicated with attendees before the start of the event.

Access the latest COVID-19 guidelines from:

Sponsorship opportunities

The conference will offer a variety of sponsorship opportunities for your organization to optimize your visibility to attendees. Learn about sponsorship opportunities.

Organizers

Gerald Hart University of Georgia
Lance Wells University of Georgia
Interview

How does the sugar O-GlcNAc regulate nuclear and cytosolic proteins?

Jerry Hart and Lance Wells discuss how their meeting will gather experts in the field to explore this question.

Image: Y835 H-bonds to a helix proximal to UDP-GlcNAc in OGT-substrate complex. Structure from Schimpl et al, 2012. PDB: 4AY6.

Sponsors

Registration

ASBMB members receive a $50 discount off their registration fee, which will be applied during check-out.

Not a member? Join the ASBMB and save!

  Early registration
(by May 9)
Regular registration
(by June 6)
Trainee with single lodging $700 $750
Trainee commuter (no lodging) $350 $400
PI/Industry with single lodging $1,050 $1,100
PI/Industry commuter (no lodging) $700 $750

What’s included

The full conference package includes:

Attendees are on their own for dinners.

Note: Lodging is not included in commuter registration rates.

Hotel accommodation

Lodging arrangements will be made at the University of Georgia Center for Continuing Education & Hotel. All accommodation arrangements must be made through ASBMB during the registration process.

If you require an early arrival or late departure (one night pre- and/or post-meeting) you may purchase these additional nights during the registration process, $120 per room per night inclusive of taxes.

Registration changes

Registration changes will be accepted as space allows until June 6, and can be made by contacting meetings@asbmb.org or calling the ASBMB accounting department at 240-283-6600.

Cancellation policy

Cancellations received in writing on or before June 6 are subject to a $100 processing fee. No refunds will be issued for cancellations after June 6, due to final guarantee commitments. Email meetings@asbmb.org and attach a copy of your meeting registration receipt/paid invoice.

Program schedule

Thursday July 7
Friday July 8
Saturday July 9
Sunday July 10

Thursday agenda

5:00 PM - 5:15 PM

Welcome and logistics

Lance Wells and Jerry Hart, University of Georgia

5:15 PM - 7:30 PM

The cycling enzymes

Catalogue and meta-analysis of the O-GlcNAcome
Stephanie Olivier-Van Stichelen, Medical College of Wisconsin
Using cryo-EM to illuminate the domain arrangement and dimerization of O-GlcNAc transferase
Richard Meek, University of York
O-GlcNAc regulates the form and function of the neurofilament cytoskeleton
Michael Boyce, Duke University
Writing and erasing O-GlcNAc from target proteins in the cell
Christina Woo, Harvard University
Comprehensive characterization of post-translational modifications on O-GlcNAc cycling enzymes
Junfeng Ma, Georgetown University
7:30 PM - 9:30 PM

Welcome reception and posters

Friday agenda

8:00 AM - 9:00 AM

Coffee and continental breakfast

9:00 AM - 12:00 PM

O-GlcNAcylation and the flow of genetic information

Coffee break at 10 a.m.

A complex interplay of RNA Pol II pausing, 5’ termination and elongation mediated by O-GlcNAcylation
Brian Lewis, National Cancer Institute
O-GlcNAc in epigenetics and signaling
John Hanover, National Institute of Diabetes and Digestive and Kidney Diseases
O-GlcNAcylation, a deceptive structural simplicity: the tree that hides the forest
Tony Lefebvre, University of Lille
Targeting the O-GlcNAc transferase to specific proteins using RNA aptamers
Yi Zhu, University of Georgia
Daily protein O-GlcNAcylation rhythm integrates circadian and metabolic signals to regulate time-of-day physiology
Xianhui Liu, University of California, Davis
Close cousins of O-GlcNAc-transferases: the O-fucosyl-transferases
Chris West, University of Georgia
Spatiotemporal control of subcellular O-GlcNAc signaling using light-inducible Opto-OGT
Qunxiang Ong, Institute of Molecular and Chemical Biology, A*STAR
12:00 PM - 2:00 PM

Lunch and posters

2:00 PM - 5:30 PM

O-GlcNAcylation and regulation of metabolism

Coffee break and posters at 4 p.m.

The intersection between O-GlcNAc, autophagy and cytoprotection
Natasha Zachara, Johns Hopkins University
The role of protein O-GlcNAcylation in mediating cardiomyocyte stress responses
John Chatham, University of Alabama at Birmingham
When pigs fly! O-GlcNAc in heart failure – From bench to bedside in 2022
Priya Umapatha, Johns Hopkins Medical Institute
IGF-1 reduces protein O-GlcNAcylation via AMPK activation in H9C2 cardiomyoblast cultured in high glucose media
Andres Medina, University of Texas Rio Grande Valley
Role of smooth muscle cell-derived O-GlcNAc transferase in diabetic atherosclerosis
Saugat Khanal, Northeast Ohio Medical University
GRASP55 senses energy and nutrient deprivation through O-GlcNAcylation to promote autophagosome–lysosome fusion and facilitate unconventional secretion of mutant huntingtin
Yanzhuang Wang, University of Michigan
Genetic deletion of MIOX ameliorates obesity-associated tubulo-interstitial injury via modulating O-GlcNAcylation of SREBP-1
Isha Sharma, Northwestern University
Dynamic regulation of cardiac myocyte voltage-gated calcium channels and calcium handling by O-GlcNAcylation
Andrew Ednie, Wright State University
Real-time chemical tools to capture and control sugar signaling in cells
Charlie Fehl, Wayne State University
5:30 PM - 6:30 PM

Beer/wine reception and posters

Saturday agenda

8:00 AM - 9:00 AM

Coffee and continental breakfast

9:00 AM - 12:00 PM

O-GlcNAcylation, immunity and signaling

Coffee break at 10 a.m.

O-GlcNAc and immunity: Chemical immunology as a powerful combination to investigate the roles of O-GlcNAcylation in the immune system
Alberto Fernandez–Tejada, CIC bioGUNE
Dual regulation of transcription in T lymphocytes by NF-kappaB c-Rel O-GlcNAcylation
Parameswaran Ramakrishnan, Case Western Reserve University
OGT in T cells and autoimmunity
Gabriela Gorelik, University of South Alabama
Intestinal epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response
Hai-Bin Ruan, University of Minnesota
O-GlcNAcylation is a crucial post-translational modification for T helper 2 cell polarization by dendritic cells
Marjolein Quik, Leiden University Medical Center
O-GlcNAc signalling in natural and accelerated vascular aging
Paula R. Barros, Medical School of Ribeirao Preto
Protein O-GlcNAcylation affects paracrine regulation of fibroblast activation and turnover by keratinocytes
Yan Wang, Cleveland Clinic Lerner Research Institute
O-GlcNAc transferase regulates formation of clathrin-mediated coated pits
Sadia Rahmani, Ryerson University
12:00 PM - 2:00 PM

Lunch and posters

2:00 PM - 5:30 PM

O-GlcNAcylation, cell growth and cancer

Coffee break and posters at 4 p.m.

O-GlcNAcylation: Linking signaling and metabolism in cancer and beyond
Maurico Reginato, Drexel University
Cell cycle and growth — Understanding the role of O-GlcNAcylation at cis-regulatory elements
Chad Slawson, University of Kansas Medical School
Importance of O-GlcNAcylation in glioblastoma tumorigenesis
Wagner B. Dias, Federal University of Rio de Janeiro
Regulation of the hedgehog pathway and medulloblastoma growth by glucose-induced O-GlcNAcylation
Huadong Pei, Georgetown University
Substrate dysregulation reveals a new role of O-GlcNAcase in p53 regulation
Chia-Wei Hu, University of Wisconsin–Madison
Defining the impact of Ca2+-dependent O-GlcNAcylation in melanoma progression
Jonathan Soboloff, Lewis Katz School of Medicine at Temple University
Regulation of O-linked N-acetyl glucosamine transferase (OGT) through E6 stimulation of the ubiquitin ligase activity of E6AP
Jun Yin, Georgia State University
Hedgehog activity regulates an O-GlcNAc-circuitry in mammary tumor-associated macrophages
Lalita Shevde–Samant, University of Alabama at Birmingham
New proteomic and chemical genetic tools to study OGT and O-GlcNAc signaling
Samuel A. Myers, La Jolla Institute for Immunology
Proteomic quantification of site-specific interplay between O-GlcNAcylation and phosphorylation in diabetic hearts
Marzieh Ayati, University of Texas Rio Grande Valley
5:30 PM - 6:30 PM

Beer/wine reception and posters

Sunday agenda

8:00 AM - 9:00 AM

Coffee and continental breakfast

9:00 AM - 12:00 AM

O-GlcNAcylation and neuronal functions and disease

Coffee break and posters at 10 a.m.

O-GlcNAc cycling regulates food intake by mediating meal memories
Olof Lagerloff, Umeå University
Chemical biology approaches for investigating the O-GlcNAc modification
David Vocadlo, Simon Fraser University
Build it to understand it: synthesis of O-GlcNAc modified proteins
Matthew Pratt, University of Southern California
Utilizing causal X-linked intellectual disability variants to gain insight into the O-GlcNAc transferase enzyme
Johnathan Mayfield, University of Georgia
Missense mutations in OGT associated with Intellectual Disability cause O-GlcNAcylation homeostasis alteration and cognitive defects in mice
Florence Authier, University of Dundee
Human pharmacology highlights the potential of the OGA Iinhibitor ASN51 as an ideal once-a-day oral drug for the treatment of neurodegenerative diseases
Ryan Schubert, Asceneuron SA
12:00 PM - 12:15 PM

Concluding remarks

Lance Wells and Jerry Hart, University of Georgia

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