Sept. 28 – Oct. 2, 2022 | Seattle

The interplay between epigenetic regulation and genome stability

The interplay between epigenetic regulation and genome stability
Sept. 28 – Oct. 2, 2022 | Sheraton Grand, Seattle

It is clear that epigenetic and chromatin states impact DNA replication and DNA repair, two key processes critical for maintaining genome integrity. However, most meetings on epigenetics and chromatin focus on transcription, while most meetings on genome integrity include little attention to epigenetics and chromatin. The goal of this conference is to bring together scientists who are interested in epigenetic regulation and genome integrity for discussion and interactions. This conference will bridge this gap to link researchers who are interested in epigenetic regulations and chromatin with those who are interested in genome integrity.

In addition to the scientific focus, we will promote interactions between two societies, the American Society for Biochemistry and Molecular Biology and the Biophysical Society of China. The first joint conference of the two societies was held in China in 2019 and was very successful, and we look forward to holding the conference in the U.S. in 2022.

The major focus of this meeting will be the dynamic interplay among chromatin, including histone modifications and high-order chromatin structure, and processes related to genome integrity, including DNA replication, repair and damage response. Moreover, we will determine how the interplay goes awry in cancer and aging cells.

Important dates

Aug. 2 Early registration deadline
Aug. 18 Abstract submission deadline
Sept. 1 Registration deadline

Sponsorship opportunities

The conference is offering a variety of sponsorship opportunities for your organization to optimize your visibility to attendees. Learn about sponsorship opportunities.

Organizers

Jessica Tyler Cornell University
Zhiguo Zhang Columbia University Irving Medical Center
Guohong Li Institute of Biophysics, Chinese Academy of Sciences

Keynote speakers

Geneviève Almouzni Institut Curie
John Diffley Francis Crick Institute

COVID-19 vaccination requirement

For the health and safety of attendees, COVID-19 vaccination is required for anyone attending this conference. Mask-wearing and other requirements will be based on state and local guidelines and will be communicated with attendees before the start of the event.

Access the latest COVID-19 guidelines from:

Sponsors

What’s included

The registration rates include:

  • All scientific sessions, poster sessions and meeting materials.
  • Morning/afternoon refreshments on meeting days.
  • Dinner on final evening of the conference.

Note: Lodging is not included in the registration rates.

Registration changes

Registration changes will be accepted as space allows until Aug. 30, 2022, and can be made by contacting meetings@asbmb.org.

Cancellation policy

Cancellations received in writing on or before Aug. 30, 2022, are subject to a $100 processing fee. No refunds will be issued for cancellations after Aug. 30 due to final guarantee commitments. Email meetings@asbmb.org and attach a copy of your meeting registration receipt/paid invoice.

Hotel accommodations

Participants are responsible for securing and paying for their own housing arrangements. A discounted rate of $169 + tax per night has been arranged at the Sheraton Grand Seattle.

Sheraton Grand Seattle
1400 Sixth Avenue
Seattle, WA 98101

Reservations

Online

By phone: Call 206-447-5547 and ask for the ASBMB Epigenetics Conference 2022 group rate. Rooms will be available at the group rate until Thursday, Sept. 1, or the room block sells out, whichever comes first.

Program schedule

Wednesday September 28
Thursday September 29
Friday September 30
Saturday October 1
Sunday October 2

Wednesday agenda

5:30 PM - 9:50 PM

Name badge pickup

7:15 PM - 8:15 PM

Keynote address I

Investigating how DNA replication initiates in eukaryotes
John Diffley, Francis Crick Institute
8:30 PM - 9:50 PM

Session 1: Replicating the epigenome

Breaking symmetry: Asymmetric histone inheritance in drosophila male germline stem cells
Xin Chen, Johns Hopkins University; HHMI
Defect in parental histone H3-H4 tetramer transfer decreases the homologous recombination frequency
Chuanhe Yu, University of Minnesota
The mechanism of replication fork stalling at G-quadruplexes
Dirk Remus, Memorial Sloan Kettering Cancer Center Chair

Thursday agenda

9:00 AM - 12:30 PM

Session 2: Repairing the epigenome

Charting the response to DNA damage
Daniel Durocher, University of Toronto
An isoform-specific function of NSD3 in DNA repair
Zhenkun Lou, Mayo Clinic
53BP1 regulates heterochromatin epigenetics through liquid phase separation
Youwei Zhang, Case Western Reserve University
Homeostatic histone acetylation via the H3K4me-Rpd3L axis promotes genome integrity during transcription–replication conflicts
Cheng-Fu Kao, Institute of Cellular and Organismic Biology, Academia Sinica
Mechanisms of genome integrity by bromodomain chromatin reader proteins
Kyle Miller, University of Texas at Austin
Activation of homologous recombination in G1 preserves centromeric integrity
Evi Soutoglou, University of Sussex Chair
Multivalent BARD1-nucleosome interactions facilitate H2A ubiquitylation by BRCA1/BARD1
Peter S. Brzovic, University of Washington
Recent progresses in epigenetic drug discovery
David Li, MedChemExpress
2:30 PM - 6:00 PM

Session 3: Modifying the epigenome to maintain genome integrity and its dysregulation in cancer

EZHIP and K27M impede H3K27me3 spreading by inhibiting allosterically stimulated PRC2 in gliomas
Peter Lewis, University of Wisconsin–Madison
Epigenetics: a gatekeeper to DNA amplification & rearrangements
Johnathan Whetstine, Fox Chase Cancer Center
Exploring oncohistone mutations at functional sites of ADP-ribosylation in breast cancers
Andrea D. Edwards, University of Texas Southwestern Medical Center
Specific dependency of H3.1K27M DMG on chromatin remodeler CHD2
Xu Zhang, Columbia University
Orc6 is a component of the replication fork and enables efficient mismatch repair
Supriya Prasanth, University of Illinois Urbana–Champaign
Epigenetic dependence of high grade glioma
Zhiguo Zhang, Columbia University School of Medicine
KMT2A maintains cancer cell genome stability and contributes to tumorigenesis in human hepatocellular carcinoma
Liang Sha, University of Southern California
Specificity of histone acetylation antibodies and methods for their detection
Michael Keogh, EpiCypher
8:00 PM - 10:00 PM

Poster session 1

Friday agenda

9:00 AM - 12:30 PM

Session 4: Chromosome dynamics during genome maintenance

The DNA replication machinery regulates heterochromatin assembly and epigenetic inheritance
Songtao Jia, Columbia University
Epigenetic regulation of DNA re-replication and extrachromosomal DNA
Josh Black, University of Colorado Denver/Anschutz Medical Campus
Epigenetic manipulation of cancer genome maintenance through macroH2A1 alternative splicing
Philipp Oberdoerffer, Johns Hopkins School of Medicine
Changes in DNA double-strand break repair during aging correlate with an increased rate of genomic mutations
Jennifer Cobb, University of Victoria
Exploiting self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress
Claus Storgaard Sørensen, University of Copenhagen Biotech Research & Innovation Centre
When silence is golden: role of silencing in heterochromatin repair
Irene Chiolo, University of Southern California Chair
Non-canonical regulatory role of KAT5 chromodomain, independent of histone marks, in NuA4 function during genome expression and maintenance
Jacques Cote, Laval University Cancer Research Center
2:30 PM - 3:30 PM

Discussion topic: Career choices in biological sciences

  • Jia Cheng, Scientific Editor, Cell
  • Supriya Prasanth, Professor and Head, Department of Cell and Developmental Biology, University of Illinois at Urbana–Champaign
  • Irene Chiolo, Associate Professor, University of Southern California
  • Michael Keogh, Chief Scientific Officer, EpiCypher
  • Richard Adeyemi, Assistant Professor, Fred Hutchinson Cancer Research Center
7:30 PM - 10:20 PM

Session 5: Structural and functional insights into chromatin replication and repair (Virtual session from China)

Replisome and histone chaperone orchestrate to guide histone partitioning during DNA replication
Qing Li, Peking University
Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1
Ruiming Xu, Institute of Biophysics
FIP11 competes with the Bloom syndrome helicase for binding to stalled replication forks to preserve genome stability
 
Jun Huang, Zhejiang University
Genome folding by cohesin
Hongtao Yu, Westlake University
Structure and functions of the 30-nm chromatin fiber in gene regulation and epigenetic inheritance
Guohong Li, Institute of Biophysics, Chinese Academy of Sciences Chair
The RPA–RNF20–SNF2H axis promotes accurate chromosome segregation and homologous recombination repair
Xuefeng Chen, Wuhan University

Saturday agenda

9:00 AM - 12:35 PM

Session 6: Genome maintenance during growth, development and carcinogenesis

Regulation of stalled fork dynamics by the protexin complex
Richard Adeyami, Fred Hutchinson Cancer Research Center
Genome regulation through R-loops
Kavitha Sarma, Wistar Institute
The mutational consequences of transcription factor binding during DNA replication
Olivier Boivin, Duke University
H2Ax dependent mechanisms that stabilize chromatin contacts within developing lymphocytes
Patrick L. Collins, Ohio State University
Genome-wide mapping of protein–DNA interactions
Steven Henikoff, Fred Hutchinson Cancer Research Center Chair
Histone variants impact genome integrity during cellular senescence and cancer progression in human tissues
Yamini Dalal, National Cancer Institute
Acetylation of H3K56 aids chromatin accessibility during UV-induced nucleotide excision repair in Saccharomyces cerevisiae
Preeti Khan, St. Xavier's College
Structured RNAs restrict the N6-adenine methylation (m6dA) activity of human METTL3-METTL14
 
Yogesh Gupta, University of Texas Health Science Center at San Antonio
2:00 PM - 3:40 PM

Session 7: Chromatin remodeling to maintain genome integrity

Histone chaperone connectivity in the histone chaperone network
Colin Hammond, Novo Nordisk Foundation Center for Protein Research
Specific killing of BRCA1-deficient cancer cells by depletion of EXO1
Haico van Attikum, Leiden University Chair
Genome-wide CRISPR screen identifies synthetic lethal partners of ARID1A
Louis-Alexandre Fournier, BC Cancer
Modeling PBAF complex mutations in the melanocytic lineage reveals unique functions of individual subunits
Elena Grossi, Icahn School of Medicine at Mount Sinai
3:45 PM - 5:45 PM

Poster Session II

Sunday agenda

9:00 AM - 10:40 AM

Session 8: Nucleosome assembly during DNA replication and repair

Regulation of quiescence (G0) exit through chromatin
 
Toshi Tsukiyama, Fred Hutchinson Cancer Center
Helicase activation in the absence of DNA synthesis disrupts chromatin and results in un-replicated gaps at origins
Dave MacAlpine, Duke University Chair
Developing a cell-specific chromatin immunocleavage assay to profile chromatin modifications in the Drosophila male testis
Jennifer A. Urban, Johns Hopkins University
ATM kinase-dependent regulation of SR splicing factors upon DNA damage
Komal Raina, Tata Institute of Fundamental Research
11:00 AM - 12:00 PM

Keynote address II

H3 variants in chromatin states and cell fate
Geneviève Almouzni, Institut Curie

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