2022 ASBMB Annual Meeting

Sessions

Enzymology

Organizers: Tadhg Begley, Texas A&M University
Catherine Drennan, Massachusetts Institute of Technology

Enzyme structure and function

Session chair: Catherine Drennan, Massachusetts Institute of Technology

  • Repairing enzymes using spare parts
    Catherine Drennan, Massachusetts Institute of Technology
  • Machinery in motion: New insights into mitochondrial proteostasis
    Gabriel Lander, Scripps Research Institute
  • Structural biology of natural product biosynthetic enzymes
    Janet Smith, University of Michigan
  • An aerobic strategy for C-H bond functionalization
    Jennifer Birdwell-Rabb, University of Michigan

Frontiers in enzymology

Session chair: Tadhg Begley, Texas A&M University

  • Riboflavin catabolism: The destruction of an icon
    Tadhg Begley, Texas A&M University
  • Correlated motions in enzymes
    Nozomi Ando, Cornell University
  • Nickel pincer nucleotide: biosynthesis and function
    Robert Hausinger, Michigan State University
  • Bacterial biosynthesis of natural products
    Katherine Ryan, University of British Columbia

Radical SAM enzymology

Session chair: TBD

  • Radical SAMs and the vast unexplored chemistry of RiPP natural products
    Douglas Mitchell, University of Illinois Urbana-Champaign
  • The biosynthesis of lipoic acid: A saga of death, destruction and rebirth
    Squire Booker, Pennsylvania State University
  • Unraveling the secrets of radical SAM mechanisms
    Joan Broderick, Montana State University
  • How do aerobic organisms solve the oxygen sensitivity problem of [4Fe-4S] in radical SAM enzymes?
    Hening Lin, Cornell University; Howard Hughes Medical Institute

Glycobiology

Organizers: Valerie Weaver, University of California, San Francisco
Stephen Withers, University of British Columbia

Structure/function and manipulation and imaging of the glycocalyx

Session chair: Stephen Withers

  • Nanoscale physical biology of the cellular glycocalyx
    Matthew J. Paszek, Cornell University
  • MALDI imaging mass spectrometry mapping of the glycocalyx
    Richard R. Drake, Medical University of South Carolina
  • Genetic and small molecule strategies to edit the glycocalyx
    Siriram Neelamegham, State University of New York at Buffalo
  • Enzymatic removal of cell surface antigens as a route towards universal O type blood and organs
    Stephen Withers, University of British Columbia

Glycans in cell biology

Session chair: Susan Bellis

  • Hypersialylation of tumor cells promotes pancreatic cancer progression
    Susan Bellis, University of Alabama at Birmingham
  • Receptor N-glycosylation links metabolism with signaling
    James Dennis, Lunenfeld Tanenbaum Research Institute
  • Modeling the mucinous glycocalyx to unravel receptor pattern recognition by influenza A viruses
    Kamil Godula, University of California, San Diego
  • Cell surface glycan engineering reveals that matriglycan alone can recapitulate dystroglycan binding and function
    Geert-Jan Boons, University of Georgia

Physiological impact of glycans in tissue homeostasis and disease — focus on cell–ECM interactions

Session chair: Valerie Weaver

  • The glycocalyx in tumor progression and metastasis
    Valerie Weaver, University of California, San Francisco
  • The heparaase/syndecan-1 axis in cancer progression
    Ralph D. Sanderson, University of Alabama at Birmingham
  • TBD
    Avery Posey, University of Pennsylvania
  • TBD
    Kelly Ten Hagen, National Institute of Dental and Craniofacial Research

Membranes/Lipids

Organizers: Tamas Balla, National Institutes of Health
Lois Weisman, University of Michigan

Organizing signaling domains through non-vesicular lipid transfer and membrane contacts

Session chair: Orna Cohen-Fix, National Institute of Diabetes and Digestive and Kidney Diseases

  • Regulation of PIP2 homeostasis at ER-plasma membrane contacts by Nir proteins
    Jen Liou, University of Texas Southwestern Medical Center
  • Roles for inter-organelle contacts in organizing metabolism
    W. Mike Henne, University of Texas Southwestern Medical Center
  • Systematic analysis of membrane contact sites
    Maya Schuldiner, Weizmann Institute of Science
  • Novel pathways of intracellular membrane lipid transport and neurodegenerative diseases
    Pietro De Camilli, Yale University School of Medicine; Howard Hughes Medical Institute

Novel approaches to understand membrane composition and structure

Session chair: Lois Weisman, University of Michigan

  • Chemical tools for understanding phospholipase D signaling
    Jeremy Baskin, Cornell University
  • TBD
    Tamas Balla, National Institutes of Health
  • Volume electron microscopy analysis reveals a new type of membrane junction required for mixing of parental genomes after fertilization
    Orna Cohen-Fix, National Institute of Diabetes and Digestive and Kidney Diseases
  • Automatic whole cell organelle segmentation in volumetric electron microscopy
    Aubrey Weigel, Howard Hughes Medical Institute Janelia Research Campus

Membrane dynamics in trafficking and signaling

Session chair: Tamas Balla, National Institutes of Health

  • TBD
    Lois Weisman, University of Michigan
  • Novel mechanisms in phosphoinositide turnover
    Raghu Padinjat, National Centre for Biological Sciences
  • Regulation of COPII dynamics in development and disease
    Anjon Audhya, University of Wisconsin-Madison
  • Intracellular trafficking during neutrophil chemotaxis
    Carole Parent, University of Michigan

Metabolism

Organizers: Scott Dixon, Stanford University
Marian Walhout, University of Massachusetts Medical School

Metabolism and model systems 

Session chair: Marian Walhout, University of Massachusetts Medical School

  • Interplay between metabolism and gene expression
    Marian Walhout, University of Massachusetts Medical School
  • Identifying toxic metabolites and their roles in disease
    Dohoon Kim, University of Massachusetts Medical School
  • Transcriptional regulation of primary and specialized metabolism
    Siobhan Brady, University of California, Davis
  • Interorgan crosstalk and metabolism regulation in Drosophila
    Norbert Perrimon, Harvard University

Conplex metabolic interactions

Session chair: Stavroula Hatzios, Yale University

  • Metabolic adaptation to oxidative stress at the host-microbe interface
    Stavroula Hatzios, Yale University
  • Deconvoluting host-gut microbiota co-metabolism
    Pamela Chang, Cornell University
  • The tiny pharmacists within: how the human gut microbiome impacts drug metabolism and disposition
    Peter Turnbaugh, University of California, San Francisco
  • Metabolic outliers in human disease
    Ralph DeBerardinis, University of Texas Southwestern Medical center

Metabolic mechanisms

Session chair: Scott Dixon, Stanford University

  • Lipid metabolism and ferroptosis
    Scott Dixon, Stanford University
  • Too much and never enough: Synthetic excess and metabolic inefficiency of aneuploidy in tumorigenesis
    Emma Watson, Harvard Medical School
  • Uncovering conditional vulnerabilities in cancer
    Jason Cantor, University of Wisconsin
  • The genetics of tumor suppression by p53
    Maureen Murphy, Wistar Institute

Protein machines and disorder

Organizers: Martin Beck, Max Planck Institute of Biophysics
Tanja Mittag, St. Jude Children’s Research Hospital

Macromolecular machines

Session chair: TBD

  • In situ structural analysis of the nuclear pore complex
    Martin Beck, Max Planck Institute of Biophysics
  • Structure and function of DNA transposition assemblies
    Orsolya Barabas, University of Geneva
  • Molecular-scale structure of a high-curvature membrane
    Adam Frost, University of California, San Francisco

Phase transitions of structured complexes and cellular machinery

Session chair: TBD

  • Structured and disordered proteins collaborate to drive membrane remodeling
    Jeanne Stachowiak, University of Texas at Austin
  • Phase separation shapes form and function of the nucleolus
    Richard Kirwacki, St. Jude Children’s Research Hospital
  • Decoding plasticity of the dark proteome
    Edward Lemke, Johannes Gutenberg University; Institute of Molecular Biology

Physiological and pathological phase transitions of disordered proteins

Session chair: TBD

  • Phase behavior of intrinsically disordered prion-like domains
    Tanja Mittag, St. Jude Children’s Research Hospital
  • Regulation of translation and deadenylation via biomolecular condensates
    Julie Forman-Kay, Hospital for Sick Children
  • Polyubiquitin effects on phase transitions of shuttle protein UBQLN2
    Carlos Castañeda, Syracuse University
  • The role of phase transitions in transcription
    Ibrahim Cissé, California Institute of Technology

Organelles

Organizers: Jeffrey Brodsky, University of Pittsburgh
Elizabeth Vierling, University of Massachusetts, Amherst

Quality control in the early secretory pathway

Session chair: Jeffrey Brodsky, University of Pittsburgh

  • The degradation of misfolded proteins in the ER
    Jeffrey Brodsky, University of Pittsburgh
  • Post-translational control of HMG CoA reductase, the rate-limiting enzyme of cholesterol synthesis
    Russell DeBose–Boyd, University of Texas Southwest Medical Center
  • Signaling principles, signal decoding and integration revealed by stress
    Diego Acosta-Alver, University of California, Santa Barbara
  • The role of rhomboid pseudoproteases in ERADicating misfolded membrane substrates
    Sonya Neal, University of California, San Diego

Organelles and cellular homeostasis

Session chair: Elizabeth Vierling, University of Massachusetts, Amherst

  • Mechanisms of membrane protein sorting
    Sichen (Susan) Shao, Harvard Medical School
  • Peroxisomal quality control in Arabidopsis
    Bonnie Bartel, Rice University
  • Mitochondrial-derived compartments protect cells from nutrient stress
    Adam Hughes, University of Utah
  • Regulation of mitochondrial genome synthesis in animal cells
    Samantha Lewis, University of California, Berkeley

Organizing the cytoplasm during stress

Session chair: Stephanie Moon, University of Michigan

  • Mechanisms of stress granule regulation by ribosome-associated quality control factors
    Stephanie Moon, University of Michigan
  • Control of translation by ubiquitin during oxidative stress
    Gustavo Silva, Duke University
  • Proteins directing lipid fluxes at the ER-lipid droplet continuum
    Elina Ikonen, University of Helsinki
  • The interconnected dynamics of ribonucleoprotein condensates and the endoplasmic reticulum
    Jason Lee, Baylor College of Medicine

RNA/DNA

Organizers: Chuan He, University of Chicago
Karolin Luger, University of Colorado, Boulder

Machines on chromatin

Session chair: Karolin Luger, University of Colorado, Boulder

  • Cracking the nucleus: Finding order in chaos
    Clodagh O'Shea, Salk Institute
  • EM structures of nucleosomes with chaperones
    Karolin Luger, University of Colorado Boulder
  • Structural mechanism of human telomerase holoenzyme
    Kelly Nguyen, Medical Research Council Laboratory of Molecular Biology
  • Studying DNA-related processes on DNA curtains
    Ilya Finkelstein, University of Texas at Austin

Noncoding RNA regulation of chromatin states and transcription

Session chair: Chuan He, University of Chicago

  • m6A in the action of regulating the regulators
    Kathy (Fange) Liu, University of Pennsylvania
  • Regulation of noncoding RNA in space and time
    John Rinn, University of Colorado Boulder
  • RNA methylation multitasking on chromatin
    Blerta Xhemalce, University of Texas at Austin
  • RNA methylation in gene expression regulation
    Chuan He, University of Pennsylvania

New approaches to visualize nucleic acids

Session chair: Timothy Stasevich, Colorado State University

  • Visualizing RNA in life cells
    Timothy Stasevich, Colorado State University
  • Visualizing the dynamic genome during development
    Allistair Bottiger, Stanford University
  • 3D in situ RNA sequencing
    Xiao Wang, Broad Institute; Massachusetts Institute of Technology
  • Engineering the repetitive 3D genome in human disease
    Jennifer Phillis-Cremins, University of Pennsylvania

Signaling

Organizers: Patrick Eyers, University of Liverpool
Anne-Claude Gingras, Lunenfeld–Tanenbaum Research Institute

Atypical signaling mechanisms

Session chair: Patrick Eyers, University of Liverpool

  • Protein AMPylation and ubiqutin
    Vincent Tagliabracci, University of Texas Southwestern Medical Center
  • Pseudokinases and cell signaling
    Natalia Jura, University of California, San Francisco
  • Atypical protein phosphorylation on His and Lys
    Tony Hunter, Salk Institute
  • Discovering the missing phosphoproteome
    Claire Eyers, University of Liverpool

New approaches for global cell signalling

Session chair: Pedro Beltrao, European Bioinformatics Institute

  • Large scale phosphoproteomics, dynamics and function
    Judit Villén, University of Washington
  • Quantitative imaging for cell signalling
    Lucas Pelkmans, University of Zürich
  • Proximity labelling based MS applied to signalling
    Anne-Claude Gingras, Lunenfeld–Tanenbaum Research Institute
  • Microscope-based method to dissect cellular heterogeneity
    Doug Fowler, University of Washington

Bringing the dead to life: Pseudoenzymes

Session chair: Janet Thornton, European Bioinformatics Institute

  • Pseudoenzyme-based cell signalling
    Patrick Eyers, University of Liverpool
  • Functional protein sharing and moonlighting
    Constance Jeffrey, University of Illinois
  • DUBS and psuedo-DUBs controlling inflammation
    Elton Zeqiraj, University of Leeds
  • Inactive and active kinase functions in one polypeptide
    Martin Eilers, University of Wurzburg