Certificates of attendance

Download a certificate of attendance/presentation from the Registration Resource Center by entering your email address and badge number.

The 2022 ASBMB Annual Meeting, held in conjunction with Experimental Biology, will take place in person April 2–5 in Philadelphia.

Join thousands of scientists from multiple disciplines with shared research interests. Present your latest findings, hear inspiring lectures, participate in workshops, and form new bonds that will help you achieve the most important work of your career.

Experience four days of immersive and insightful exchange among life scientists from around the world.

About EB

The Experimental Biology conference — hosted by five scientific societies supporting studies in biochemistry and molecular biology, anatomy, pharmacology, physiology and pathology — attracts thousands of researchers and exhibitors.

Starting in 2023, the five societies will be parting ways. So don’t miss this last chance to converse and forge collaborations with scientists from multiple disciplines with shared research interests.

Program planning committee co-chairs

Vahe Bandarian
Vahe Bandarian
University of Utah
Martha Cyert
Martha Cyert
Stanford University

See full list of organizers >

from ASBMB Today
Discover BMB: A reimagining of our annual meeting

“Once leadership has made a decision, such as completely changing the context in which our annual meeting occurs, nothing is sacrosanct,” program planning committee co-chairs Karen Allen and Craig Cameron write.

ASBMB names 2023 award winners

Don’t miss their lectures at #DiscoverBMB in March in Seattle.

Call for proposals: Essential, mission-driven programming at Discover BMB

All of the programming at the meeting in March in Seattle will be designed by members. The ball's in your court.

What you need to know

thumbnail

Program schedule

Deepen your knowledge of significant research trends during daily sessions curated by pioneers and innovators.

thumbnail

Award lectures

These high-profile speakers will cover impactful research and education and diversity initiatives.

thumbnail

Workshops

Leading experts offer practical advice for adopting the latest tools, software, methodologies and best practices to propel your work from bench to publication.

thumbnail

Undergraduate Poster Competition

The Undergraduate Poster Competition returns in person on Saturday, April 2.

thumbnail

Interest groups

Share new findings and best practices and engage in activities and discussions that forge lasting and fruitful connections.

thumbnail

Housing information

Reserve your room at the official EB hotel.

thumbnail

Annual meeting travel awards

The ASBMB offers more than $270,000 in awards to assist first authors presenting research at the annual meeting.

thumbnail

Exhibits and sponsorships

Information for exhibitors and sponsors.

Program schedule

All sessions and events will take place at the Pennsylvania Convention Center unless otherwise noted.

Saturday April 2
Sunday April 3
Monday April 4
Tuesday April 5

Saturday agenda

9:00 AM - 11:00 AM

Research Education Interest Group — Connecting the community for the benefit of student outcomes

Organizers: Ellis Bell, University of San Diego, and Regina Stevens–Truss, Kalamazoo College

This session will present recent research on the impact of collaboration between students and institutions in course-based undergraduate research experiences. Attendees will have the opportunity to join a team of like-minded faculty to network and develop action items for future discussion and research. Attendees will be able to connect with colleagues.

Join the Research Education Interest Group Slack channel

Future challenges in education research
Daniel Dries, Juniata College
Bringing student research experiences to everyone
Betsy Martinez–Vas, Hamline College
Pedagogical research: It's not just for DBERs anymore
Jessica Bell, University of San Diego
Fostering student collaborations through CUREs
Kevin Callahan, St. John Fisher College
10:30 AM - 4:00 PM

Undergraduate Student Poster Competition

Open to selected candidates only.

  • 10:30 – 11:00 a.m.
    Orientation
  • 11:00 a.m. – 12:00 p.m.
    Check-in and poster setup
  • 11:00 a.m. – 12:00 p.m.
    Judges' orientation
  • 12:00 – 3:30 p.m.
    Undergraduate Student Poster Competition
  • 3:30 – 4:00 p.m.
    Poster removal
12:45 PM - 2:45 PM

Lipids Interest Group — Novel insight into roles of lipids in signaling and human disease

Organizers: Michael Airola, Stony Brook University, and John Burke, University of Victoria

This session will inform participants about the most cutting-edge lipid research being performed. Most of the speakers will be postdocs and graduate students. The session will cover a wide range of biochemical, biophysical and cellular approaches to study lipid signaling, in line with the organizers' approach for their successful ASBMB Lipid Research Division Seminar Series. By keeping a broad range of topics, we hope to provide novel collaborative opportunities.

Join the Lipids Interest Group Slack channel

Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane
Idil Ulengin–Talkish, Stanford University
Membrane phosphoinositides stabilize GPCR–arrestin complexes and offer temporal control of complex assembly and dynamics
John Janetzko, Stanford University
Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex
Dimitris Papagiannidis, Heidelberg University
Imaging cytoplasmic lipid droplets in vivo with fluorescent perilipin 2 and perilipin 3 knock-in zebrafish
Meredith Wilson, Carnegie Institution for Science
12:45 PM - 2:45 PM

Chemical Biology Interest Group — Emerging chemical approaches to complex biology

Organizers: Minkui Luo, Memorial Sloan Kettering Cancer Center, and Jianmin Gao, Boston College

Chemical biology can be broadly defined as a research field relying on chemical tools to interrogate biology for discovery and perturbation. The ASBMB has the historical mission to advance the research of biochemistry and molecular biology through diverse approaches and platforms. Such a mission establishes a key common ground between the ASBMB and the chemical biology community given complementary strength and interest. The Chemical Biology Interest Group aims to better promote crosstalk between the two fields. Importantly, we will primarily dedicate speaking opportunities to emerging young investigators as well as people from historically marginalized groups. The talks will showcase the emerging technologies that chemical biologists are developing to tackle complex biological problems. Chemical biologists will benefit from the perspectives and questions raised by experts in biology. Biologists will mutually benefit by considering broad utilities of the chemical biology tools and methods.

Join the Chemical Biology Interest Group Slack channel

Chemical biology applied to hematologic disorders
Laura Dassama, Stanford University
Protein-targeting cyclic peptides as chemical biology tools
Min Xue, University of California, Riverside
Interrogating novel acetylation substrates with probes based on fluorine-thiol displacement reaction
Rongsheng (Ross) Wang, Temple University
Activity-based probes for an ancient family of RNA modifying enzymes
Ralph Kleiner, Princeton University
12:45 PM - 2:45 PM

Signaling Interest Group — New paradigms in hormonal regulation of cancer and development

Organizers: Marina Holz, New York Medical College, and Mythreye Karthikeyan, University of Alabama, Birmingham

This session will cover the role of hormones in cancer and parallel developmental programs with emphasis on new insights, paradigms and mechanisms, and future directions. Attendees will learn about new areas of investigation and consideration of emerging paradigms in hormonal signaling.

Join the hormonal regulation Signaling Interest Group Slack channel

Hormonal control of sex differences in neural gene expression
Jessica Tollkuhn, Cold Spring Harbor Laboratory
Novel insights into GnRH receptor signaling and the central control of fertility
Daniel Bernard, McGill University
Spatial metabolic regulation and endocrine resistance in metastatic breast tumors
Zeynep Madak–Erdogan, University of Illinois Urbana–Champaign
TLE3 ensures luminal epithelial cell fate in breast cancer by acting as a co-repressor for FOXA1
Ruth Keri, Case Western Reserve University
12:45 PM - 2:45 PM

Glycobiology Interest Group — Glycobiology at the cutting edge

Organizers: Nadine Samara, National Institute of Dental and Craniofacial Research, and Stacy Malaker, Yale University

The session will feature speakers from academia, industry, startups and funding agencies who perform high-risk/high-reward glycobiology research that will take the field forward. Attendees will learn about the future of glycobiology and appreciate its importance in biomedical research. Early-career glycoscientists will learn about the possible paths they can pursue.

Join the Glycobiology Interest Group Slack channel

Adventures with bacterial peptidoglycans
Catherine Grimes, University of Delaware
Inspiring glycoscience innovation: A story of chembind glycoscience
Yunpeng Liu, Chembind LLC
New protein tools for generation and enrichment of O-linked glycopeptides
Christopher Taron, New England Biolabs
Mucins, glycans and coronavirus transmission
Jessica Kramer, University of Utah
12:45 PM - 2:45 PM

Protein Interest Group — Membrane proteins

Organizers: Matthias Buck, Case Western University, and Fran Barrera, University of Tennessee

The goal of this interest group session is to build a community of researchers in the field of membrane proteins. The study of membrane proteins is living a golden era, as strides are being made toward understanding how these key proteins function. This event will highlight recent advances in a broad range of membrane proteins that are central players in key cellular processes.

Join the Membrane Proteins Interest Group Slack channel

Delivery of recombinant SARS-CoV-2 envelope protein into the membranes of living human cells from amphipol solutions
Charles R. Sanders, Vanderbilt University
TRPV channels gating by endogenous and exogenous modulators
Vera Moiseenkova, University of Pennsylvania
Candidalysin uses a unique mechanism to form membrane pores
Francisco Barrera, University of Tennessee, Knoxville
Activation mechanism of the EGF receptor
John Kuriyan, University of California, Berkeley
12:45 PM - 2:45 PM

Neuroscience Interest Group

Organizers: Jason Yi and Harrison Gabel, Washington University School of Medicine in St. Louis

This session will feature recent work in the field examining pathways and molecules that cause neurological dysfunction, with a particular emphasis on genetic neurodevelopmental disorders.

Join the Neuroscience Interest Group Slack channel

Function genetic dissection of disease-linked variants in UBE3A
Jason Yi, Washington University School of Medicine in St. Louis
Dissecting neuron-specific epigenetic mechanisms in neurodevelopmental disorders
Harrison Gabel, Washington University School of Medicine in St. Louis
The role of chromatin in neuronal function and neurodevelopmental disorders
Erica Korb, University of Pennsylvania
Optical interrogation of dopaminergic phenotypes in neurofibromatosis type 1
J. Elliott Robinson, Cincinnati Children’s Hospital
3:00 PM - 5:00 PM

Enzymology Interest Group

Organizers: Juan Mendoza, University of Chicago, and Kayunta Johnson, University of Texas at Arlington

The interest group session will be have talks by new and mid-career investigators and networking opportunities. The research to be presented will be focused on the structure–function of enzymes essential to cellular function and cellular regulation and relevant to human health and disease. Techniques and cutting-edge research include X-ray crystallography, cryo-EM, NMR, enzyme kinetics, enzymology and protein engineering. Attendees will be exposed to a diverse panel of researchers performing cutting-edge science. Participants will gain insights into how some scientists use combined structure and engineering approaches to elucidate key enzymatic processes of cells. New investigators will leave with insight related to their careers and respective fields through a Q&A session related to research, diversity, inclusion and promotion.

Join the Enzymology Interest Group Slack channel

Illuminating the natural biochemistry of lanthanides and leveraging it for biomining, bioseparations, biosensing, and health applications
Joseph Cotruvo, Jr., Pennsylvania State University
An affinity-matured DLL4 ligand for broad-spectrum activation and inhibition of Notch signaling
Vince Luca, Moffitt Cancer Center
Molecular mechanisms of biased signaling at the angiotensin receptor
Laura Wingler, Duke University
Allosteric regulation of metabolic enzymes ACLY and G6PD
Ronen Marmorstein, University of Pennsylvania
3:00 PM - 5:00 PM

Protein Interest Group — Post-translational modification: emerging topics and techniques

Organizers: Lauren Ball, Medical University of South Carolina, and Fangliang Zhang, University of Miami

The goal of this session is to provide a forum enabling interaction of scientists interested in the elucidating the impact of regulatory post-translational modifications on physiology, disease and drug response. Attendees will learn about discoveries relating to the role of PTMs in diseased or normal physiologies and have the opportunity to start new collaborative research.

Join the Post-translational Modification Interest Group Slack channel

Protein arginylation in animal cells
Anna Kashina, University of Pennsylvania
Detection of single protein molecules with quantum effects
Lan Yang, Washington University in St. Louis
Identifying regulators of protein O-GlcNAcylation
Natasha Zachara, Johns Hopkins School of Medicine
Protein posttranslational modifications at the virus–host interface
Ileana Cristea, Princeton University
3:00 PM - 5:00 PM

Mitochondria Interest Group — Multifaceted mitochondria

Organizers: Laura Lackner, Northwestern University, and Oleh Khalimonchuk, University of Nebraska–Lincoln

The session seeks to promote cross-talk across the areas of basic mitochondrial biology and molecular mechanisms of disease and aging, and provide an opportunity for biomedical researchers to explore and discover potentially unrecognized mechanisms of disease. Holding an interest group session that focuses on the diverse aspects of mitochondria and pathways that underlie the pathophysiologic mechanisms of age-associated diseases will provide a forum to uniquely gather the international community of scientists in mitochondria, cell metabolism and aging research. The overarching goal is to organize an exciting and interactive interest group session, expand the array of participants and trigger new synergy among researchers in the mitochondria and age-associated disease fields. We also aim to provide an excellent training experience for young scientists and foster professional connections between junior and more established investigators.

Join the Mitochondria Interest Group Slack channel

Uncovering novel circuits of electron flow in the mammalian electron transport chain
Jessica Spinelli, Whitehead Institute for Biomedical Research
Structure-based insights into control of heme biosynthesis
Breann Brown, Vanderbilt University
Phosphorylation-based regulation of mitochondrial metabolism
Natalie Niemi, Washington University in St. Louis
Expanding the set of genetically encoded tools for compartment-specific manipulation of redox metabolism in living cells
Valentin Cracan, Scintillion Institute; Scripps Research
3:00 PM - 5:00 PM

Signaling Interest Group — Emerging mechanisms of cellular communication in physiology and disease

Organizers: Michelle Mendoza, University of Utah Huntsman Cancer Institute, and Robert Zoncu, University of California, Berkeley

This session will cover new mechanisms in intra- and intercellular communication that have been uncovered through quantitative and structural biology. Attendees will get a broad overview of new signaling questions and approaches.

Join the cellular communication Signaling Interest Group Slack channel

The tumor mechanical microenvironment instructs metastatic behavior of breast cancer cells
Ghassan Mouneimne, University of Arizona
Regulation of GPCR signaling at the Golgi
Roshanak Irannejad, University of California, San Francisco
High resolution insights into receptor tyrosine kinase signaling across the membrane
Natalia Jura, University of California, San Francisco
Unconventional GPCR-PKA signaling in the hedgehog pathway
Benjamin Myers, University of Utah
4:30 PM - 5:30 PM

Undergraduate student workshop: Speed networking

Students will have the opportunity to network with professionals from various biochemistry and molecular biology career fields.

6:00 PM - 7:00 PM

Tang Lecture

7:00 PM - 8:30 PM

EB opening reception

Sunday agenda

7:00 AM - 8:00 AM

ASBMB member and first-time attendee orientation

8:00 AM - 8:45 AM

ASBMB welcome and business meeting

8:45 AM - 9:15 AM

Herbert Tabor Research Award lecture

My journey with cAMP-dependent protein kinase
Susan Taylor, University of California, San Diego
9:30 AM - 11:30 AM

Enzyme structure and function

Riboflavin catabolism: the destruction of an icon
Tadhg Begley, Texas A&M University
Repairing enzymes using spare parts
Catherine Drennan, Massachusetts Institute of Technology Chair
Machinery in motion: New insights into mitochondrial proteostasis
Gabriel Lander, Scripps Research Institute
An aerobic strategy for C-H bond functionalization
Jennifer Bridwell–Rabb, University of Michigan
9:30 AM - 11:30 AM

Structure/function and manipulation and imaging of the glycocalyx

Nanoscale physical biology of the cellular glycocalyx
Matthew J. Paszek, Cornell University
MALDI imaging mass spectrometry mapping of the glycocalyx
Richard R. Drake, Medical University of South Carolina
Genetic and small molecule strategies to edit the glycocalyx
Siriram Neelamegham, State University of New York at Buffalo
Enzymatic removal of cell surface antigens as a route towards universal O type blood and organs
Stephen Withers, University of British Columbia Chair
9:30 AM - 11:30 AM

Macromolecular complexes

In situ structural analysis of the nuclear pore complex
Martin Beck, Max Planck Institute of Biophysics Chair
Molecular-scale structure of a high-curvature membrane
Adam Frost, University of California, San Francisco
Structure and function of DNA transposition assemblies
Orsolya Barabas, University of Geneva
Conformational dynamics of SNARE recycling mediated by NSF
Ucheor Choi, West Virginia University
9:30 AM - 11:30 AM

Machines on chromatin

Cracking the nucleus: Finding order in chaos
Clodagh O'Shea, Salk Institute
EM structures of nucleosomes with chaperones
Karolin Luger, University of Colorado Boulder Chair
Structural mechanism of human telomerase holoenzyme
Kelly Nguyen, Medical Research Council Laboratory of Molecular Biology
Studying DNA-related processes on DNA curtains
Ilya Finkelstein, University of Texas at Austin
9:30 AM - 11:30 AM

Epigenetics and aging: can we turn back the clock?

A sex-specific role for long noncoding RNA in depression susceptibility and resilience
Orna Issler, Icahn School of Medicine at Mount Sinai
Rethinking the stress paradigm: Exploring new connections between epigenetic adaption and cellular stress
Kaushik Ragunathan, University of Michigan Medical School
Extracellular vesicles as stress signals: Identifying novel systemic mechanisms of trauma programming
Tracy Bale, University of Maryland School of Medicine
Sex-dimorphism in aging: are we missing half of the picture?
Bérénice Benayoun, University of Southern California
9:30 AM - 11:30 AM

Quality control in the early secretory pathway

The degradation of misfolded proteins in the ER
Jeffrey Brodsky, University of Pittsburgh Chair
Post-Translational control of HMG CoA reductase, the rate-limiting enzyme of cholesterol synthesis
Russell DeBose–Boyd, University of Texas Southwest Medical Center
Signaling principles, signal decoding and integration revealed by stress
Diego Acosta–Alver, University of California, Santa Barbara
The role of rhomboid pseudoproteases in ERADicating misfolded membrane substrates
Sonya Neal, University of California, San Diego
9:30 AM - 11:30 AM

Inclusive and civil communication

Chair: Erin Sayer, University of Nebraska–Lincoln

Seeing equity in courses from data to faculty learning communities
Chad Brassil, University of Nebraska–Lincoln
Creative strategies to perform an inclusive faculty search (Part I)
Anita Corbett, Emory University
Creative strategies to perform an inclusive faculty search (Part II)
Wendy Gilbert, Yale University
Listening to and partnering with students to build inclusive STEM communities
Sarah Bunnell, Amherst College
9:30 AM - 11:30 AM

Atypical signaling mechanisms

Chair: Patrick Eyers, University of Liverpool

Expanding the kinome
Vincent Tagliabracci, University of Texas Southwestern Medical Center
Structural basis for signaling by the HER3 pseudokinase
Natalia Jura, University of California, San Francisco
Tracing copper utilization by kinase signal transduction pathways: Implications for cancer cell processes
Donita C. Brady, University of Pennsylvania
Non-canonical Ubiquitination
Satpal Virdee, University of Dundee
9:30 AM - 11:30 AM

Metabolism and model systems

Regulation of metabolic network function with enzyme expression
Safak Yilmaz, University of Massachusetts
Identifying toxic metabolites and their roles in disease
Dohoon Kim, University of Massachusetts Medical School Chair
Transcriptional regulation of primary and specialized metabolism
Siobhan Brady, University of California, Davis
Interorgan crosstalk and metabolism regulation in Drosophila
Norbert Perrimon, Harvard University
9:30 AM - 11:30 AM

Organizing signaling domains through non-vesicular lipid transfer and membrane contacts

Chair: Orna Cohen-Fix, National Institute of Diabetes and Digestive and Kidney Diseases

Regulation of PIP2 homeostasis at ER-plasma membrane contacts by Nir proteins
Jen Liou, University of Texas Southwestern Medical Center
Roles for inter-organelle contacts in organizing metabolism
W. Mike Henne, University of Texas Southwestern Medical Center, Dept. of Cell Biology
Systematic analysis of membrane contact sites
Maya Schuldiner, Weizmann Institute of Science
Novel pathways of intracellular membrane lipid transport and neurodegenerative diseases
Pietro De Camilli, Yale University School of Medicine/Howard Hughes Medical Institute
11:45 AM - 12:15 PM

Meet the experts

12:15 PM - 1:45 PM

Advocacy Town Hall

Sponsored by the ASBMB Public Affairs Advisory Committee

Join the ASBMB Public Affairs Advisory Committee to hear about the intersection of policy and science. What policies has the Biden administration enacted to support the nation’s biomedical research enterprise? And how can federal agencies support researchers still struggling with the impacts of COVID-19 and related university and laboratory shutdowns. ASBMB Public Affairs Director Sarina Neote will be joined by the PAAC chair, Rick Page, who will field your questions on politics, science policy and getting involved in advocacy.

12:30 PM - 1:00 PM

Meet the experts

12:45 PM - 2:00 PM

Poster sessions

1:00 PM - 2:00 PM

Accreditation program Q&A session

2:15 PM - 2:45 PM

ASBMB–Merck Award lecture

The phase of fat: mechanisms and physiology of lipid storage
Robert V. Farese & Tobias Walther, Harvard University
2:45 PM - 3:15 PM

William C. Rose Award lecture

Progress toward understanding protein control of reaction outcome in the diverse reactivity of iron (II) — and 2-oxoglutarate-dependent oxygenases
J. Martin Bollinger, Pennsylvania State University
3:30 PM - 4:30 PM

Spotlight Sessions

Oral presentations selected from volunteer abstracts.

3:30 PM - 4:50 PM

JBC Herbert Tabor Early Career Investigator Awards

Chair: George DeMartino, University of Texas Southwestern Medical Center

The evolution and mechanism of GPCR proton sensing
Jacob Rowe, University of Miami Miller School of Medicine
Structures and kinetics of Thermotoga maritima MetY reveal new insights into the predominant sulfurylation enzyme of bacterial methionine biosynthesis
Jodi Brewster, University of Wollongong
SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis
Armin Bayati, McGill University
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template
Calvin Gordon, University of Alberta
3:30 PM - 4:30 PM

Walter A. Shaw Young Investigator Award in Lipid Research lecture and spotlight session

Snapshots of lipid synthesis and fat storage
Michael Airola, Stony Brook University
3:30 PM - 5:00 PM

ASBMB Award for Exemplary Contributions to Education lecture and session

It's all about the students
Joseph Provost, University of San Diego
3:30 PM - 4:30 PM

Enzymes in the spotlight

Transformations of phosphonates by non-heme iron-dependent oxygenases
David Zechel, Queen's University
Structural remodelling of the carbon–phosphorus enzymatic machinery by a dual ATP-binding cassette module
Ditlev Egeskov Brodersen, Aarhus University
Mechanism and evolution of [4+2] cyclases in monoterpene indole alkaloid biosynthesis
Matthew D. DeMars, Max Planck Institute for Chemical Ecology
Structurally investigating a niche pathway for chemical reversal of proline hydroxylation in the pathogen Clostridioides difficile
Lindsey R. F. Backman, Massachusetts Institute of Technology Chair
3:30 PM - 4:30 PM

New links between glycoproteins, tissue development and disease

Conformationally altered hyaluronan mitigates the symptoms of Parkinson disease in mice
Tzu-Yu Sun, National Cheng Kung University
Exploring new bacterial–fungal interactions: The role of mannan degradation in Streptococci growth
Taylor Ticer, Medical University of South Carolina Chair
OTX2's dual mode of degradation is regulated by O-GlcNAcylation
Eugenia A. Wulff Fuentes, Medical College of Wisconsin
Maternal Zika virus infection alters offspring hippocampal glycan sulfation patterns in nonhuman primates
Kimberly Michele Alonge, University of Washington
3:30 PM - 4:30 PM

Emerging metabolic techniques and mechanisms

A selenium–iron axis dictates cancer cell sensitivity to pharmacologic ascorbate
Connor S.R. Jankowski, Princeton University
A tandem activity-based sensing and labeling strategy enables imaging of transcellular hydrogen peroxide signaling
Marco Messina, University of California, Berkeley
Ketones improve the mitochondrial coupling efficiency of brown adipocytes
Zahra Moazzami, University of Minnesota
An organism-wide atlas of tissue crosstalk in physical activity
Wei Wei, Stanford University Chair
3:30 PM - 4:30 PM

From molecular condensation to protein sorting

Structure of a pathologic amyloid nucleus determined by rational genetic deconstruction of an intracellular nucleation barrier
Randal Halfmann, Stowers Institute for Medical Research Chair
Interplay between TPR nucleoporin and TREX-2 complex in mRNA export
Mary Dasso, National Institute of Child Health and Human Development
Engineered nuclear import receptor karyopherin-β2 chaperones aberrant phase transitions of disease-associated cargo
Charlotte M. Fare, University of Pennsylvania
Proteasome localization is regulated through mitochondrial respiration and kinase signaling
Kenrick A. Waite, University of Kansas Medical Center
3:30 PM - 4:30 PM

Membrane and membrane-free organelles and quality control

Identification of signaling pathways and phase separating domains that drive cajal body formation
Madelyn Kaye Logan, University of Mississippi Medical Center
Self-assembling long coiled-coil proteins driving the formation of a nanoscale cylindrical architecture at human centrosomes
Jong il Ahn, National Cancer Institute
Client specificity of an ATP-independent chaperone is regulated by a temperature sensitive switch
Alex Siegel, California Institute of Technology Chair
Investigating mitochondrial dysfunction in Barth syndrome
Olivia L. Sniezek, Johns Hopkins School of Medicine
3:30 PM - 4:30 PM

Atypical signaling

First-in-class deubiquitylase inhibitors reveal new enzyme conformations
Francesca Chandler, University of Leeds
Unconventional GPCR-PKA signaling in the hedgehog pathway
Benjamin Myers, University of Utah School of Medicine
Non-canonical recruitment of PKA catalytic subunits to RIα-driven biomolecular condensates
Julia C. Hardy, University of California, San Diego Chair
The plastoglobule-localized AtABC1K6 is a Mn2+-dependent protein kinase necessary for timely transition to reproductive growth
Peter K Lundquist, Michigan State University
3:30 PM - 4:30 PM

DNA/RNA regulation of nuclear processes

The role of substrate deformation in context-dependent non-CG DNA methylation
Jikui Song, University of California, Riverside
Epigenetics: A gatekeeper to DNA amplification and replication control
Johnathan R. Whetstine, Fox Chase Cancer Center Chair
Rotational dynamics of the MLL complex on nucleosome and its implication in heterogeneity of the epigenetic landscape
Yali Dou, University of Southern California
Transcriptional regulation via strand displacement DNA repair in G-quadruplexes
Amy Whitaker, Fox Chase Cancer Center
4:00 PM - 5:00 PM

Lipids shaping membranes and creating signaling platforms

Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane
Martha Cyert, Stanford University
ATG9 vesicles are incorporated into nascent autophagosome membranes
Taryn J. Olivas, Yale University
From flat to bulb — novel insights in caveolae membrane curvature
Claudia Matthaeus, National Heart, Lung and Blood Institute Chair
Membrane phosphoinositides stabilize GPCR-arrestin complexes and provide temporal control of complex assembly and dynamics
John Janetzko, Stanford University
4:45 PM - 5:45 PM

Spotlight Sessions

Oral presentations selected from volunteer abstracts.

4:45 PM - 5:45 PM

Chromatin structure, remodeling and gene expression

Molecular investigation of the TTD and PHD histone binding domains of the epigenetic regulator UHRF2
Brittany N. Albaugh, Eastern Michigan University Chair
Protection of telomeres 1b modulates cellular ROS and chromatin structure in Arabidopsis thaliana
Claudia Castillo–González, Texas A&M University
Transcriptome and regulome signatures of multiple myeloma induced by bone marrow stromal cells
Sebastian Dziadowicz, West Virginia University
Structural and biophysical characterization of plasmodium falciparum bromodomain protein 1
Ajit Kumar Singh, University of Vermont
4:45 PM - 5:45 PM

RNA: processing, transport and regulatory mechanisms

Divalent cation driven liquid-liquid phase separation of disordered acidic proteins
Joshua E. Mayfield, University of California, San Diego Chair
Imaging mRNAs with corrected RNA stability
Weihan Li, Albert Einstein College of Medicine
Detecting RNA dynamics in live mammalian cells with fluorescence lifetime-based sensors
Esther Braselmann, Georgetown University
The effects of tail truncations of pre-messenger RNA splicing protein Dib1
Virginia McGrath, Trinity University
4:45 PM - 5:45 PM

Protein synthesis and interactions

Biochemical characterization of SARS-CoV-2 spike RBD mutations and their impact on ACE2 receptor binding
Abdullah Hoter, University of Veterinary Medicine Hannover Chair
Predicting protein function and orientation on a gold nanoparticle surface using a residue-based affinity scale
Joanna Xiuzhu Xu, Mississippi State University
AP profiling: Resolving co-translational protein folding pathways and chaperone interactions in vivo
Xiuqi Chen, Johns Hopkins University
Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease
Angel D'Oliviera, University of Delaware
4:45 PM - 5:45 PM

Chemical biology and drug discovery in acute and chronic disease

Zinc-chelating BET bromodomain inhibitors selectively accumulate and affect gene expression in pancreatic β-Cells
Rachel A. Jones Lipinski, Medical College of Wisconsin Chair
Design and synthesis of bi-aryl methylated lactam derivatives to inhibit the BRD7 bromodomain function in prostate cancer
Sandra Carolina Ordonez–Rubiano, Purdue University
RPI-194 is a novel troponin activator that increases the calcium sensitivity of striated muscle contraction
Zabed Mahmud, University of Alberta
Anthraquinone derivatives inhibit telomerase activity by interaction with G quadruplex DNA and acts as a promising anticancerous agent
Arpita Dey, Indian Institute of Technology, Roorkee
4:45 PM - 5:45 PM

New innovations in “omic” technology

Evidence for widespread cytoplasmic structuring into mesoscopic condensates
Martin Wühr, Princeton University Chair
A meta-transcriptomic analysis of complicated diverticulitis tissue: The role of xenobiotics in the gut
Brittney Nichole McMullen, Juniata College
Targeted metabolomics reveals plasma biomarkers and metabolic alterations of the aging process in healthy young and older adults
Jeffrey Patterson, Arizona State University
Lipidomics identifies novel circulating markers of CVD risk in African American and Caucasian women
Paula Gonzalez, University of Wisconsin–Madison
4:45 PM - 5:45 PM

GPCR signaling

Novel GPR87/SDC-1 complex modulates lacritin rescue of homeostasis
Karina Dias Teixeira, University of Virginia Chair
Untangling frizzled functions
Katie Hollis, Van Andel Institute
Proton-gated coincidence detection is a common feature of GPCR signaling
Daniel G. Isom, University of Miami Miller School of Medicine
A model of potassium-assisted olfactory sensory neuron response to odorant
Melissa Singletary, Auburn University College of Veterinary Medicine
4:45 PM - 5:45 PM

Pathogen–host interactions

The MCF toxin of the extracellular pathogen vibrio vulnificus is activated by and targets host GTPases
Alfa Herrera, Northwestern University Chair
Nuclear entry of DNA tumor viruses: Finding the LINC in nuclear transport
Chelsey Cierra Spriggs, University of Michigan
Nonstructural protein 1 of SARS coronavirus interacts with stress granule protein G3BP1 and accumulates in the stress granule
Anita Nag, University of South Carolina Upstate
Protease-induced excitation of dorsal root ganglion neurons in response to acute perturbation of the gut microbiota is associated with visceral hypersensitivity
Corey Carl Baker, Queen's University
4:45 PM - 5:45 PM

Structure of proteins involved in signaling and lipid metabolism

A quantitative native mass spectrometry platform for deconstructing hierarchical organization of membrane proteins and lipids
Aniruddha Panda, Yale University School of Medicine Chair
Structure and dynamics of human perilipin 3 membrane association
Yong-Mi Choi, Stony Brook University
Auto-inhibitory interactions of Sec7, master regulator of the Golgi complex
Bryce A. Brownfield, Cornell University
Trabecular meshwork cholesterol levels regulate actin polymerization and tunneling nanotubes
Ting Wang, Indiana University School of Medicine
4:45 PM - 5:45 PM

Innovative teaching strategies in the STEM classroom

Connecting the dots: Students' mental organization and storage of biochemistry visual literacy skills
Cassidy R. Terrell, University of Minnesota Chair
Teaching collaboration skills to undergraduate biochemistry and chemistry students
Pamela S. Mertz, St. Mary's College of Maryland
Using autonomy to drive the development of students into budding scientists
Daniel R. Dries, Juniata College
Using student movement to improve understanding of the pyruvate dehydrogenase complex
Melissa A. Mullen Davis, Millersville University
6:00 PM - 7:30 PM

Control of inflammation by dietary interventions

Organizer: Michael N. Sack, National Heart, Lung and Blood Institute

This workshop will explore how different dietary components and/or temporal dietary intake strategies play a role in modulating inflammation and disease pathophysiology. Explore how specific nutrients via diverse regulatory mechanisms — transcription, GPCR signaling, post-translational modification and metabolic signaling — alter immune cell responsiveness.

Attendees will learn about integration of environmental cues with intracellular regulatory pathways to drive immune cell responsiveness.

Target audience: Scientists focusing on cardiometabolic risk, nutrient signaling, inflammation and effects of dietary interventions on health.

6:00 PM - 7:30 PM

Approaches to teaching in the biosciences using different course modalities

Organizer: Monica Rieth, Southern Illinois University, Edwardsville

Become familiar with new modes of instruction. Learn to work outside of your teaching comfort zone by incorporating new exercises and lessons that align with other teaching modalities.

The workshop will include ways to incorporate new teaching modalities into biochemistry education both in the classroom and in the lab using examples and evidence-based practices reported in the current literature. Exercises and sample lessons will be implemented to help attendees adapt new techniques to their current and future practices.

For example, a lesson on amino acids and protein structure may be taught in a lecture-style format and attendees would be asked to adapt this lesson to a flipped-style classroom or problem-based learning exercise. How would each person change the format/content using examples to illustrate these changes?

Attendees will also be asked to identify and/or anticipate any advantages or disadvantages to changing to a new teaching modality, such as increased/decreased student engagement. Open discussions will further introduce attendees to teaching practices as of yet unreported in the literature.

Attendees will develop a network of peers who can provide support to them.

Target audience: Instructors teaching undergraduate- or graduate-level biochemistry courses or labs both for majors and nonmajors. Those interested in exploring different teaching styles and modalities in their courses.

6:00 PM - 7:30 PM

Increasing diversity through master's degree programs

Organizer: Bob Rose, North Carolina State University

Network with other faculty members contributing to programs for research-based master's degrees.

We developed a research-based master's program in biochemistry from an NSF S-STEM training grant to fund low-income students and increase diversity of associated departments. Our funding is ending, and we are looking for ideas for continued funding of the program and developing support in a Ph.D.-focused department.

Target audience: Graduate faculty involved with STEM education.

6:00 PM - 7:30 PM

The power of storytelling

Storytelling is an essential component of communication. It can be used to connect with a diverse audience and make challenging subjects more accessible. Mastering storytelling requires creative flexibility, dexterity with language and willingness to get personal. Learn how to incorporate yourself as a scientist into your science story in a way that strengthens your message without sacrificing scientific integrity. This interactive session will lead participants through hands-on storytelling training that is based on one of the modules from the ASBMB course The Art of Science Communication.

6:00 PM - 7:30 PM

Success in scientific publishing workshop

Will my data stand the test of time?

Is my writing clear, compelling and engaging?

Will I be able to reach an audience that will give my research its greatest impact? 

These are questions authors ask themselves when preparing manuscripts for publication. 

The American Society for Biochemistry and Molecular Biology is home to the Journal of Biological Chemistry, the Journal of Lipid Research, and Molecular & Cellular Proteomics. In this 90-minute workshop, members of the society’s publications staff will offer insights into the publication pipeline and provide you with tips on three essential topics: presenting data, writing well and sharing your work.

Presenting:

  • Ken Farabaugh, Developmental Editor
  • Stephanie Paxson, Journal Marketing Associate
6:00 PM - 7:30 PM

Women scientists networking event — The evolution of work–life integration in the time of COVID-19

Integrating work and personal life is challenging and has been made even more so for women during the COVID-19 pandemic. The ASBMB Women in Biochemistry and Molecular Biology Committee is hosting its annual networking dinner and a panel discussion titled “The evolution of work–life Integration in the time of COVID-19.” Lea Vacca Michel of the Rochester Institute of Technology, winner of the society’s Early-Career Leadership Award, and Marlene Belfort of the University at Albany, winner of the Mid-Career Leadership Award, will be panelists. 

They will be joined by members at various career levels to discuss their experiences with integrating work and their personal lives during the pandemic. Attendees are encouraged to weigh in during the discussion.

7:00 PM - 9:00 PM

ASBMB welcome reception

Sponsored by the ASBMB Minority Affairs Committee

Monday agenda

8:00 AM - 8:30 AM

DeLano Award for Computational Biosciences lecture

Hyperbolic geometry in biological systems
Tatyana Sharpee, Salk Institute for Biological Studies
8:30 AM - 9:00 AM

Avanti Award in Lipids lecture

PI 3-Kinase signaling: A journey in three AKTs
Alex Toker, Beth Israel Deaconess Medical Center
9:15 AM - 11:15 AM

Frontiers in enzymology

Chair: Tadhg Begley, Texas A&M University

Structural biology of natural product biosynthetic enzymes
Janet Smith, University of Michigan
Correlated motions in enzymes
Nozomi Ando, Cornell University
Nickel pincer nucleotide: biosynthesis and function
Robert Hausinger, Michigan State University
Bacterial biosynthesis of natural products
Katherine Ryan, University of British Columbia
9:15 AM - 11:15 AM

Glycans in cell biology

Hypersialylation of tumor cells promotes pancreatic cancer progression
Susan Bellis, University of Alabama at Birmingham Chair
Receptor N-glycosylation links metabolism with signaling
James Dennis, Lunenfeld–Tanenbaum Research Institute
Modeling the mucinous glycocalyx to unravel receptor pattern recognition by influenza A viruses
Kamil Godula, University of California, San Diego
Cell surface glycan engineering reveals that matriglycan alone can recapitulate dystroglycan binding and function
Geert-Jan Boons, University of Georgia
9:15 AM - 11:15 AM

Phase transitions of structured complexes and cellular machinery

Building the microtubule cytoskeleton via phase transitions
Sabine Petry, Princeton University
Selective transport in the nuclear pore complex
David Cowburn, Albert Einstein College of Medicine
Understanding how oncogenic fusion proteins drive aberrant gene expression through phase separation
Richard Kriwacki, St. Jude Children’s Research Hospital
Decoding plasticity of the dark proteome
Edward Lemke, Johannes Gutenberg University; Institute of Molecular Biology Chair
9:15 AM - 11:15 AM

Noncoding RNA regulation of chromatin states and transcription

m6A in the action of regulating the regulators
Kathy (Fange) Liu, University of Pennsylvania
RNA in the loop
Jeannie Lee, Massachusetts General Hospital
RNA methylation multitasking on chromatin
Blerta Xhemalce, University of Texas at Austin
RNA methylation in gene expression regulation
Chuan He, University of Pennsylvania Chair
9:15 AM - 11:15 AM

Epigenetic regulation of metabolism: from bench to bedside

Intergenerational inheritance of altered metabolism phenotypes after early-life stress in Caenorhabditis elegans
Sarah Hall, Syracuse University Chair
Epigenetic mediators of risk for metabolic disease
Mary Elizabeth Patti, Harvard Medical School
Early-life stress and epigenomic regulation of behavior
Julie-Anne Balouek, Princeton University
Live fast, die young: The role of epigenetics in stress and aging
Anthony Zannas, University of North Carolina
9:15 AM - 11:15 AM

Organelles and cellular homeostasis

Chair: Elizabeth Vierling, University of Massachusetts, Amherst

Mechanisms of membrane protein sorting
Sichen (Susan) Shao, Harvard Medical School
Peroxisomal quality control in Arabidopsis
Bonnie Bartel, Rice University
Mitochondrial-derived compartments protect cells from nutrient stress
Adam Hughes, University of Utah
Regulation of mitochondrial genome synthesis in animal cells
Samantha Lewis, University of California, Berkeley
9:15 AM - 11:15 AM

Strategies for assessment in higher education

Peer collaboration and review: A guide to iterative improvement in learning
Dan Bernstein, University of Kansas
What makes a competitive applicant? Assessing students for graduate/professional school applications
Erin Sayer, University of Nebraska–Lincoln
Developing BMB assessment questions for use in the undergraduate classroom
Victoria Moore, Elon University Chair
9:15 AM - 11:15 AM

New approaches for global cell signalling

Chair: Vincent Tagliabracci, University of Texas Southwestern Medical Center

Large scale phosphoproteomics, dynamics and function
Judit Villén, University of Washington
CRISPR sensors for signaling
Stéphane Angers, University of Toronto
Proximity-dependent sensors for signaling
Anne-Claude Gingras, Lunenfeld–Tanenbaum Research Institute
Proteome-scale amino acid resolution footprinting of protein-binding sites in the intrinsically disordered regions
Ylva Ivarsson, Uppsala University
9:15 AM - 11:15 AM

Complex metabolic interactions

Metabolic adaptation to oxidative stress at the host–microbe interface
Stavroula Hatzios, Yale University Chair
Deconvoluting host–gut microbiota co-metabolism
Pamela Chang, Cornell University
The tiny pharmacists within: how the human gut microbiome impacts drug metabolism and disposition
Peter Turnbaugh, University of California, San Francisco
Metabolic outliers in human disease
Ralph D. DeBarardinis, University of Texas Southwestern Medical Center
9:15 AM - 11:15 AM

Novel approaches to understand membrane composition and structure

Chair: Lois Weisman, University of Michigan

Chemical tools for understanding phospholipase D signaling
Jeremy Baskin, Cornell University
Control of the cellular lipid landscape by inositol lipids
Tamas Balla,
Volume electron microscopy analysis reveals a new type of membrane junction required for mixing of parental genomes after fertilization
Orna Cohen-Fix, National Institute of Diabetes and Digestive and Kidney Diseases
A novel homeostatic mechanism tunes PIP2-dependent signaling at the PM
Gerry Hammond, University of Pittsburgh School of Medicine
11:30 AM - 12:00 PM

Meet the experts

12:00 PM - 2:00 PM

ASBMB career programming at EB Career Central

Bite-size sessions focused on developing key skills to support your career progression and exploring different career paths available to those with scientific training.

The art of the interview: Ask great questions, give great answers and enjoy the process

No matter where you are in your career, having great interview skills can help you make the next step. When it comes down to brass tacks, an interview is just a conversation. Laurel Oldach, a scientist-turned-science-writer at the ASBMB, will talk about both sides of interviewing: how you can make the most of informational interviews that you conduct and how you can feel more relaxed and prepared when you’re the interviewee.

Exploring careers in science publishing

Ever wonder what it is like to work behind the scenes to bring research to publication? Join members of the ASBMB publications staff to explore the variety of positions in publishing that benefit from scientific training. Speakers will share insights into the different roles, the day-to-day and how to make the leap from research to publishing.

Managing your mentoring relationships through mentoring up

Once you have found a mentor, what comes next in making the most of this relationship? Richard McGee of Northwestern University Feinberg School of Medicine will focus on the essential and critical elements of effective mentoring relationships, with an emphasis on mentoring up — how students and postdocs can use these principles to guide and help their mentors provide what they are seeking from them.

Science policy skills — helpful for scipol and beyond

Whether you are interested in science policy as a possible career or enjoy advocacy to support your science, there is a subset of skills necessary to make you an attractive job candidate or skilled advocate. But did you know that those same skills can help you be a better scientist too? Join ASBMB Public Affairs Director Sarina Neote and members of the society’s Public Affairs Advisory Committee to learn about how to improve those soft skills — and apply them no matter where your career takes you.

12:15 PM - 12:45 PM

Meet the experts

12:30 PM - 1:45 PM

Poster sessions

1:00 PM - 2:00 PM

Building community through ASBMB Student Chapters

2:00 PM - 2:30 PM

Earl and Thressa Stadtman Distinguished Scientist Award lecture

Telomerase holoenzymes
Kathleen Collins, University of California, Berkeley
2:30 PM - 3:00 PM

Mildred Cohn Award in Biological Chemistry lecture

Flavivirus NS1: Structure and function of an enigmatic virulence factor
Janet Smith, University of Michigan
3:15 PM - 4:15 PM

Spotlight Sessions

Oral presentations selected from volunteer abstracts.

3:15 PM - 4:30 PM

Exciting biological insights revealed by proteomics: A Molecular & Cellular Proteomics presentation

Chair: Pierre Thibault, Institute for Research in Immunology and Cancer

Antigen discovery for development of personalized cancer immunotherapy
Michal Bassani–Sternberg, Ludwig Institute for Cancer Research
Multiomic view on HLA class I and class II presentation in lung adenocarcinoma
Susan Klaeger, Broad Institute
Phosphorylated peptides as cancer neoantigens
Victor Engelhard, University of Virginia School of Medicine
3:15 PM - 5:15 PM

The Alice and C.C. Wang Award in Molecular Parasitology symposium

How one eukaryote invades and co-opts the cells of another: The story of the truly audacious toxoplasma gondii
John Boothroyd, Stanford University
Cryo-ET reveals structures and potential regulatory mechanisms of the rhoptry secretion system in apicomplexan parasites
Yi-Wei Chang, University of Pennsylvania
Chemical cartography of host-parasite-microbiome interactions in Chagas disease
Laura-Isobel McCall, University of Oklahoma
Finding the determinants of vacuole-autonomous parasite clearance using spatially targeted optical micro proteomics
Sarah Ewald, University of Virginia
3:15 PM - 4:15 PM

DNA polymerases, telomerase, replicases and replisomes

Deletion of Ch. IV telomeres via genetic engineering of a circular chromosome in the budding yeast S. cerevisiae
Melissa Anne Mefford, Morehead State University Chair
Structures of LIG1 engaging with mutagenic mismatches inserted by polβ in base excision repair
Melike Caglayan, University of Florida
Processing of DNA clamp loader subunit DnaX is important in the absence of caulobacter cell division inhibitors
Tommy F. Tashjian, University of Massachusetts Amherst
Identifying cellular and viral factor recruitment to herpes simplex virus type 1 replication forks
Jessica Packard, Duquesne University
3:15 PM - 4:15 PM

Protein modifications

SUMO 2 the rescue: How SUMO2 regulates the mitochondria via Drp1 modification
Allison H. DeHaas, Johns Hopkins University Chair
Coilin modulates nuclear organization by promoting protein SUMOylation
Katheryn Lett, University of Mississippi Medical Center
Dissecting the structural contribution of the cofilin N-terminus to actin filament severing and phosphorylation by LIMK
Joel Sexton, Yale University
Phenotypic changes produced by endogenous DNA damage in yeast mutants deficient in recombination and base excision repair
Armand Marquis Berry, Texas State University
3:15 PM - 4:15 PM

Allostery and enzyme function

The multifaceted subunit interface of malate dehydrogenase
Megan Keene, University of San Diego
Mechanism of activation of SgrAI via enzyme filamentation and mechanism of DNA sequence specificity expansion
Nancy Horton, University of Arizona
Mechanistic basis for the allosteric activation of mitochondrial glutaminase C, a key driver of glutamine metabolism in cancer cells
Thuy-Tien Thi Nguyen, Cornell University
Structural investigation of allosteric regulation in class III ribonucleotide reductases
Gisele A. Andree, Massachusetts Institute of Technology Chair
3:15 PM - 4:15 PM

Chemical biology

Microfluidic fabrication and characterization of radiopaque barium sulfate polyethylene glycol-based hydrogel microspheres
Ether Dharmesh, Saint Louis University
Acidity and nucleophilic reactivity of persulfides
Dayana Benchoam, Universidad de la República, Uruguay
Activity-based chemoproteomics reveals targets of phospholipase D-derived phosphatidyl ethanol lipids
Weizhi Yu, Cornell University Chair
Scanning-free functional fluorescence microscopy imaging toward spatial mapping of biomolecular information in live cell
Sho Oasa, Karolinska Institute
3:15 PM - 4:15 PM

Cancer signaling and therapeutics

The role of NMDA receptors subunits in the progression of inflammatory breast cancer
Laura Lizeth Mendez–Santacruz, University of Puerto Rico Chair
Nitrated Hsp90 supports glioblastoma multiforme cell survival and migration
Kyle T. Nguyen, Oregon State University
Autophagy is disrupted in the livers of obese mice exposed to asparaginase
Brian A Zalma, Rutgers University
The Sulfiredoxin-Peroxiredoxin axis promotes urethane-induced lung adenocarcinoma through the regulation of the tumor microenvironment
Yanning Hao, University of Kentucky
3:15 PM - 4:15 PM

Antibacterial targets and antibiotic resistance

Metabolic regulation of quiescence and antibiotic tolerance in uropathogenic escherichia coli
Josiah J. Morrison, University of Rhode Island Chair
Tobramycin adaptation alters the antibiotic susceptibility of pseudomonas aeruginosa quorum sensing-null mutants
Kade A. Townsend, University of Kansas
Elucidating the antibiotic sensing mechanism of VanB vancomycin-resistant Enterococci
Photis Rotsides, Drexel University College of Medicine
Lacritin bactericidal peptide N-104 targeting of inner membrane transporters FeoB and PotH (SpuG) individually absent in N-104 resistant strains of human opportunistic pathogen, P. aeruginosa PA14
Mohammad Sharifian Gh., University of Virginia
3:15 PM - 4:15 PM

Mitochondrial metabolism

SARM1 NAD hydrolase deficiency normalizes fibrosis and ameliorates cardiac dysfunction in diabetic hearts
Chi Fung Lee, Oklahoma Medical Research Foundation
Mitochondrial fission is essential to maintain cristae morphology and bioenergetics
Gabriella Robertson, Vanderbilt University
Role of mitochondrial TNAP in thermogenesis and obesity
Yizhi Sun, Dana–Farber Cancer Institute Chair
3:15 PM - 4:15 PM

Lipid homeostasis

Phosphatidic acid mediates the Nem1-Spo7/Pah1 phosphatase cascade in saccharomyces cerevisiae
Joanna M. Kwiatek, Rutgers University Chair
Citric acid cycle metabolites regulate phosphatidate phosphatase activity from the oleaginous yeast Yarrowia lipolytica
Sagar Pasham, Alabama A&M University
S1P controls endothelial sphingolipid homeostasis via ORMDL
Linda Sasset, Weill Cornell Medicine
Dishevelled localization and function are differentially regulated by structurally distinct sterols
Sonali Sengupta, Sanford Research
3:15 PM - 4:15 PM

Teaching strategies and lessons learned during COVID-19

You gotta work, BASIL! Reimagining an established CURE to provide high-quality digital learning experiences that are intentionally equitable, inclusive and accessible for all students
Arthur K. Sikora, Nova Southeastern University Chair
Moving biochemistry and molecular biology courses online in times of disruption
Kristen Procko, The University of Texas at Austin
A tale of two semesters: Flipped biochemistry curriculum in the time of COVID
Keith R. Miller, University of Mount Union
Providing effective feedback with soaring class sizes: It’s still possible
Orla M. Hart, Purdue University
4:30 PM - 5:30 PM

Spotlight Sessions

Oral presentations selected from volunteer abstracts.

4:30 PM - 5:30 PM

DNA recombination, structure and topology

Investigating the function of a unique DNA ligase (LIGK) in bdelloid rotifers
Andrew M. Schurko, Hendrix College
Development of new assays for the simultaneous measurement of DNA double-strand break repair by multiple pathways
Diego F. Valdez–Oranday, Texas State University Chair
Single-molecule analysis of in vivo DNA replication origin licensing stoichiometry
Nick Rhind, University of Massachusetts Medical School
Unique DNA polymerase kappa interactome suggests novel cellular functions
Shilpi Paul, Pennsylvania State University College of Medicine
4:30 PM - 5:30 PM

Epigenetic modifications of DNA and RNA

Activity-based profiling of RNA modifying enzymes
Ralph Kleiner, Princeton University
DNA methylation underlies the long-term association between periodontitis and atherosclerotic cardiovascular disease
Maria Febbraio, University of Alberta
Epicardial histone deacetylase 3 promotes myocardial growth through a novel microRNA pathway
Jihyun Jang, University of Maryland Chair
The impact of sorghum polyphenols on DNA methylation and signaling pathways in colon cancer
Zeguela Kamagate, Towson University
4:30 PM - 5:30 PM

RNA binding proteins

Phosphorylation-specific recruitment of human SCAF6 to RNA polymerase II during transcription regulation
Rosamaria Yvette Moreno, University of Texas at Austin Chair
Computational and biophysical analysis of RNA/protein complexes in histone mRNA degradation
Patrick Lackey, Westminster College
Asymmetric RNA egress site in expanded RNA virus by Cryo-EM and HDXMS
Sean Braet, Pennsylvania State University
The discovery of antivirals and targets for SARS-CoV-2 and EV-A71
Christina Haddad, Case Western Reserve University
4:30 PM - 5:30 PM

Chemical biology and drug discovery in infectious disease

Molecular basis for antiviral action of EDP-235: a potent and selective SARS-CoV-2 3CLpro inhibitor for the treatment of COVID-19
Anand Balakrishnan, Enanta Pharmaceuticals Inc. Chair
Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir
Calvin J. Gordon, University of Alberta
Modulation of lysosomal function as a therapeutic approach for coronaviral infections
Travis Lear, University of Pittsburgh
Antisense molecules designed to target SARS-CoV-2 are nontoxic to the host in a murine model
Colleen McCollum, University of Colorado Boulder
4:30 PM - 5:30 PM

Ubiquitin signaling

Proteins of the ubiquitin system in the Shoc2 — ERK1/2 signaling axis and Noonan-like syndrome with loose anagen hair (NSLAH) RASopathy
Emilia Galperin, University of Kentucky Chair
PLEKHA5 regulates mitotic progression by promoting APC/C localization to microtubules
Xiaofu Cao, Cornell University
An siRNA library screen for endothelial PAR1-specific deubiquitinases regulating p38 MAPK inflammatory signaling
Anand Patwardhan, University of California, San Diego
Extending the catalytic HECT domain boundaries for the HECT E3 ubiquitin ligase HACE1 increases solubility and enzymatic activity
Emma I. Kane, Clark University
4:30 PM - 5:30 PM

Apopotosis

The role of monounsaturated fatty acids in ferroptosis
Lauren Elizabeth Pope, Stanford University Chair
Effects of stimulants and HIV proteins on pyroptosis and apoptosis pathways in human brain microvascular endothelial (hBMVEC)
Joyce Chinaemerem Ikedife, New Jersey City University
A novel cell death mechanism involving the sphingosine-to-glycerophospholipid pathway
Logan Leak, Stanford University
Hypoxia re-oxygenation modelling using cancer cells expressing cell cycle and cell death probes to understand the dynamics of resistance mechanisms
Shivanshu Kumar Tiwari, Rajiv Gandhi Centre for Biotechnology
4:30 PM - 5:30 PM

Cancer metabolism

Targeting GCN2 regulation of amino acid homeostasis in prostate cancer
Ricardo Cordova, Indiana University School of Medicine
Increased fatty acid synthesis and catabolism supports metastatic breast cancer cell migration
Chaylen Jade Andolino, Purdue University
Targeting resistance in medulloblastoma
Sucheta Telang, University of Louisville Chair
Enhanced metabolism and altered paracrine signaling in glioblastoma following cytomegalovirus infection
Mark A.A. Harrison, Tulane University
4:30 PM - 5:30 PM

Membrane traffick and dynamics

SHIP164 is a chorein motif lipid transfer protein that controls endosome-golgi membrane traffic
Michael G. Hanna, Yale University School of Medicine Chair
The intracellular cholesterol pool in steroidogenic cells plays a role in autophagy, basal steroidogenesis and mitochondrial dynamics
Geetika Bassi, University of Manitoba
The effects of point mutations on the dimerization domain of ebola virus protein VP40
Jacob Conarty, Purdue University
Structural basis for specific activation of the Rab11 GTPase by the TRAPPII complex
Saket Rahul Bagde, Cornell University
4:30 PM - 5:30 PM

Lipid metabolism functions

Loss of ATAD3A contributes to NAFLD through the accumulation of lipids and damaged mitochondria
Liting Chen, University of Southern California
Pro-survival lipid metabolism activates intracellular complement signaling to induce inflammasome-mediated tumor metastasis
Alhaji H. Janneh, Medical University of South Carolina
Novel roles of FFAR4 in macrophage foam cell formation
Gage M. Stuttgen, Medical College of Wisconsin Chair
Itaconate is a negative regulator of hepatic lipid metabolism during sepsis
Rabina Mainali, Wake Forest School of Medicine
5:45 PM - 7:15 PM

RNA export at the nuclear pore complex

Organizer: Mary Dasso, Eunice Kennedy Shriver National Institute of Child Health and Human Development

RNA export is a complicated and critical stage of gene expression, which remains poorly understood. It involves components of both the RNA processing and nuclear trafficking machinery. This workshop seeks to bring together different emerging approaches and model systems that are being applied to untangle the sequence and logic of RNA processing and export events.

The focus of this workshop will be on nuclear pore proteins as guardians of mRNA export and their role in the selectivity of RNA export in health and disease. The workshop will bring together laboratories using cryo-EM, X-ray crystallography, biochemistry, nuclear microinjection, genetics, cell biology, CRISPR/Cas9-AID gene editing, live imaging, viral and animal models to elucidate interactions between nucleoporins, mRNA and RNA-accessory proteins at the nuclear pore complex.

Attendees will learn about cutting-edge tools and techniques and their application to the process of mRNA export. They will learn up-to-date progress, explore unresolved questions in the field and meet world-class experts.

Target audience: This workshop will appeal to a diverse group of scientists (students, postdoctoral researchers and group leaders) who are interested in RNA processing and export, the regulation of gene expression, nuclear trafficking and nucleoporins.

5:45 PM - 7:15 PM

Pedagogical lessons learned during the time of COVID-19

Organizer: Phillip Ortiz, State University of New York

This workshop will include a presentation of and discussions about pedagogical approaches used during the shift to teaching at a distance during the COVID-induced closing of some campuses. As we often learn more from failure than success, this workshop will include approaches that worked and that didn't.

Attendees will hear about creative and innovative approaches to teaching and learning. In addition, as it has been noted by people who were successful at shifting some or all of their teaching to different modalities that some content is better taught by those modalities (which leaves time in their courses to expand the content that requires face-to-face instruction), the workshop may lead to productive conversations about educational innovation.

Target audience: Primarily BMB educators, but also all educators at the undergraduate and graduate levels, including new and established faculty members at all types of colleges and universities, teaching assistants and postdoctoral researchers who are interested in careers at primarily undergraduate institutions. Undergraduate and graduate students also are welcome attend so that they may share their insights and experiences during the Q&A and open discussion portions of the session.

5:45 PM - 7:15 PM

Becoming the boss of your career

Organizer: Erica Gobrogge, Van Andel Institute

Establishing career goals, navigating challenging conversations associated with those goals, and working outside the laboratory to advance your career can be challenging for scientists at all career stages. In addition, these conversations can be particularly difficult for international scientists, whose cultural norms may be different than those commonly found in the U.S.

Participants will develop their own goals, draft plans for achieving them and practice navigating conversations they might encounter while advocating for those goals. The mission of this workshop is to encourage, support and empower scientists to take charge of their careers.

Target audience: This workshop primarily will be of interest to undergraduate students, graduate students and postdoctoral researchers, but scientists at career stages are welcome.

5:45 PM - 7:15 PM

Transforming scientific research into equitable outreach

How do you transform your passion for science into equitable outreach? This interactive session will cover the importance of science outreach and its impacts on enhancing diversity, equity and inclusion within the biomedical science research workforce. Chelsey Spriggs, co-founder of Black in Microbiology (#BlackInMicro) and a member of the first cohort of the ASBMB MOSAIC program, will share her journey as a role model for underrepresented students interested in biological research. She will describe how she has engaged in outreach and mentorship and how, through her work as a board member of the Black in Microbiologists Association, she aims to enhance the visibility of Black scientists in the field. Be ready to have a thoughtful discussion with your peers and brainstorm ways to use science outreach as a vehicle to equity and inclusion.

Tuesday agenda

8:00 AM - 8:30 AM

Ruth Kirschstein Diversity in Science Award lecture

Beyond diversity: Building a culture of inclusion in science
Tracy Johnson, University of California, Los Angeles
8:30 AM - 9:00 AM

Bert and Natalie Vallee Award in Biomedical Science lecture

Tissue stem cells: survival of the fittest
Elaine Fuchs, Rockefeller University
9:15 AM - 11:15 AM

Radical SAM enzymology

Chair: Tadhg Begley, Texas A&M University

Radical SAMs and the vast unexplored chemistry of RiPP natural products
Douglas Mitchell, University of Illinois Urbana-Champaign
The biosynthesis of lipoic acid: A saga of death, destruction and rebirth
Squire Booker, Pennsylvania State University
Unraveling the secrets of radical SAM mechanisms
Joan Broderick, Montana State University
How do aerobic organisms solve the oxygen sensitivity problem of [4Fe-4S] in radical SAM enzymes?
Hening Lin, Cornell University; Howard Hughes Medical Institute
9:15 AM - 11:15 AM

Physiological impact of glycans in tissue homeostasis and disease – focus on cell-ECM interactions

The glycocalyx in tumor progression and metastasis
Valerie Weaver, University of California, San Francisco Chair
The heparaase/syndecan-1 axis in cancer progression
Ralph D. Sanderson, University of Alabama at Birmingham
Reprogramming T cells to target glycans and overcome glycan-mediated immunosuppression for cancer therapy
Avery Posey, University of Pennsylvania
Orchestrated intragranular restructuring of mucins during secretory granule maturation
Kelly G. Ten Hagen, National Institute of Dental and Craniofacial Research
9:15 AM - 11:15 AM

Physiological and pathological phase transitions of disordered proteins

Phase behavior of intrinsically disordered prion-like domains
Tanja Mittag, St. Jude Children’s Research Hospital Chair
Liquid-liquid phase separation modulated by post-translational modifications and its implications for gene regulation
Tae Hun Kim, Hospital for Sick Children
Polyubiquitin effects on phase transitions of shuttle protein UBQLN2
Carlos Castañeda, Syracuse University
9:15 AM - 11:15 AM

New approaches to visualize nucleic acids

Visualizing RNA in life cells
Timothy Stasevich, Colorado State University Chair
Visualizing the dynamic genome during development
Allistair Bottiger, Stanford University
3D in situ RNA sequencing
Xiao Wang, Broad Institute; Massachusetts Institute of Technology
Engineering the repetitive 3D genome in human disease
Jennifer Phillips–Cremins, University of Pennsylvania
9:15 AM - 11:45 AM

Translational epigenetics: The apple doesn’t fall too far from the tree

Programmed epigenetic risk: Can stress exposures in utero predispose infants to obesity and metabolic diseases?
Kristen Boyle, University of Colorado Anschutz Medical Campus
The role of maternal factors in epigenetic programming of neurodevelopment
Patrick McGowan, University of Toronto Chair
Epigenetic marks identify asthma susceptibility in African Americans
Ivana Yang, University of Colorado Anschutz Medical Campus
Chronic stress, omics and asthma
Juan Celedon, Children's Hospital of Pittsburgh
9:15 AM - 11:15 AM

Organizing the cytoplasm during stress

Mechanisms of stress granule regulation by ribosome-associated quality control factors
Stephanie Moon, University of Michigan Chair
Control of translation by ubiquitin during oxidative stress
Gustavo Silva, Duke University
The interconnected dynamics of ribonucleoprotein condensates and the endoplasmic reticulum
Jason Lee, Baylor College of Medicine
9:15 AM - 11:15 AM

Bringing the dead to life: pseudoenzymes

Chair: Anne-Claude Gingras, Lunenfeld–Tanenbaum Research Institute

Catalytic degradation in pseudoenzymes
Patrick Eyers, University of Liverpool
Cell signaling by protein tyrosine phosphatases
Hayley Sharpe, Babraham Institute
New light on an old problem — molecular basis for glycogen synthase activity regulation
Elton Zeqiraj, University of Leeds
Defining pseudoenzymes in glycosylation pathways
Natarajan Kannan, University of Georgia
9:15 AM - 11:15 AM

Metabolic mechanisms

Lipid metabolism and ferroptosis
Scott Dixon, Stanford University Chair
Too much and never enough: Synthetic excess and metabolic inefficiency of aneuploidy in tumorigenesis
Emma Watson, Harvard Medical School
Uncovering conditional vulnerabilities in cancer
Jason Cantor, University of Wisconsin
The genetics of tumor suppression by p53
Maureen Murphy, Wistar Institute
9:15 AM - 11:15 AM

Membrane dynamics in trafficking and signaling

Chair: Tamas Balla

Regulation of membrane dynamics via phosphoinositide signaling cascades
Lois Weisman, University of Michigan
Novel mechanisms in phosphoinositide turnover
Raghu Padinjat, National Centre for Biological Sciences
Regulation of COPII dynamics in development and disease
Anjon Audhya, University of Wisconsin–Madison
Intracellular trafficking during neutrophil chemotaxis
Carole Parent, University of Michigan
11:30 AM - 12:00 PM

Meet the experts

12:15 PM - 12:45 PM

Meet the experts

12:30 PM - 1:45 PM

Poster sessions

2:00 PM - 2:30 PM

ASBMB Young Investigator Award lecture

Chromatin-based modulations underlying gene regulation and pathogenesis
Greg G. Wang, University of North Carolina
2:45 PM - 3:45 PM

Thermodynamics in the everyday life of biologists

Organizer: Assen Marintchev, Boston University School of Medicine

This workshop will introduce the concepts of thermodynamic coupling and binding kinetics in the context of biochemical experiments, with emphasis on practical applications and common mistakes.

Learn how to properly plan, perform and analyze binding experiments and avoid everyday errors:

  • How to use thermodynamic coupling to indirectly calculate a binding KD from the KD's of coupled interactions, if direct determination is impossible or difficult.
  • How to compare binding constants to determine whether they are mutually consistent.
  • How to determine whether and when two or more molecules bind to each other in vivo.
  • How to quantitatively evaluate experimental binding constants: what they mean for the underlying biological process and whether they are physically possible.

Target audience: Ph.D. students, postdocs and faculty members.

2:45 PM - 3:45 PM

Lipid diversity and disease: Spotlight on Journal of Lipid Research Junior Associate Editors

Chair: George Carman, Rutgers University

The role of Dennd5b in intestinal lipid absorption
Scott Gordon, University of Kentucky
Judi Simcox, University of Wisconsin–Madison
Lessons and surprises from mice with humanized bile acid composition
Rebecca A. Haeusler, Columbia University Medical Center
2:45 PM - 3:45 PM

Spotlight Sessions

Oral presentations selected from volunteer abstracts.

2:45 PM - 4:15 PM

Race and mental health in STEM

STEM graduate students and postdoctoral fellows, particularly those of color, often experience microaggressions, discrimination and harassment in the workplace, which can lead to adverse mental health outcomes. We must support these scientists by encouraging dialogue and taking action. In this session, sponsored by the ASBMB’s Maximizing Opportunities for Scientific and Academic Independent Careers program, or MOSAIC, panelists Cirleen DeBlaere of Georgia State University, Carlota Ocampo of Trinity Washington University and Stephen Quaye of Ohio State University will lead insightful discussions pertaining to the intersectionality of race and mental health of STEM trainees.

2:45 PM - 3:45 PM

Gene regulation

Histone chaperone Nucleophosmin regulates transcription of key genes involved in oral tumorigenesis
Tapas K. Kundu, Jawaharlal Nehru Centre for Advanced Scientific Research Chair
Impaired transcription elongation by RNA polymerase I results in defective ribosomal RNA processing
Abigail K. Huffines, University of Alabama at Birmingham
Protein-DNA interactomes of NKX2-5 and TBX5 mutants identified in congenital heart defects
Emmanuel Carrasquillo–Dones, University of Puerto Rico, Río Piedras
Mediator subunit MED1 differentially modulates mutant thyroid hormone receptor intracellular localization and intranuclear mobility
Moyao Wang, College of William and Mary
2:45 PM - 3:45 PM

Non-coding RNAs

Structure-function relationships for the lncRNA SChLAP1 in aggressive prostate cancer
James P. Falese, Duke University Chair
Multi-assay profiling of diminazene library reveals predictive bidirectional modulation of MALAT1 triplex stability in vitro
Martina Zafferani, Duke University
Changes in the non-coding transcriptome of short-term glucose-challenged human glomerular epithelial cells may give insights into early molecular events of diabetic kidney disease
Nik Tsotakos, Penn State Harrisburg
Long noncoding RNAs in regulation of inflammation, immune response, and glucose metabolism
Subhrangsu S Mandal, University of Texas at Arlington
2:45 PM - 3:45 PM

Metal mania

Functional diversity and structural analysis of SAM-dependent aminobutanoyl transferases
Madeline R. Shoemaker, Fort Lewis College
Kinetic and stability study on the immobilized enzymatic step of one-pot dimerization of 2-[2-(dimethylamino)ethoxy]ethanol
Kurt Espinosa, James Madison University
Characterization of the nickel-inserting cyclometallase LarC from Moorella thermoacetica and identification of a CMPylated reaction intermediate
Aiko Turmo, Michigan State University Chair
2:45 PM - 3:45 PM

Drug screening

In silico investigation of gastroprotective compounds from n-butanol fraction of costus igneus on antiulcer druggable targets
Modupe Olusola Adetayo, Babcock University
Preclinical drug development of a novel antiviral target in rotavirus
Emily-Claire Duffy, Bates College
Mechanistic insights of sulfonamide-based NLRP3 inhibitors for the treatment of neurodegenerative diseases
Hallie Blevins, Virginia Commonwealth University Chair
Anti-hypertensive effect of BPM4 on spontaneously hypertensive rats that antagonizes dopamine βeta hydroxylase
Manisha Saini, University of Delhi South Campus
2:45 PM - 3:45 PM

Novel kinase regulatory mechanisms

Quantitative mass spectrometry reveals a proteome-wide role for cyclin A and Cks1 in multisite, non-proline directed phosphorylation by CDK1
Tony Ly, University of Dundee Chair
A 14-3-3-mediated mechanism of regulation for the ubiquitin-sensing kinase TNK1
Christina Marie Egbert, Brigham Young University
Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
Sierra Cullati, Vanderbilt University
Assembly and disassembly of PKA is allosterically controlled by nucleotides and metal ions
Rodrigo A. Maillard, Georgetown University
2:45 PM - 3:45 PM

Neurobiology and neuronal signaling

Sex-specific cholinergic regulation of dopamine release mechanisms through nicotinic receptors in the nucleus accumbens
Lillian J. Brady, Vanderbilt University Chair
UBE3A hyperactivity as a driver of neurodevelopmental disease
Kellan Weston, Washington University in St. Louis
Traumatic brain injury in a Drosophila upregulates nitric oxide synthase associated with increased acute behavioral deficits and decreased survival time
Tracy Mackey, Midwestern University
Machine learning-guided engineering of cre-lox recombination for comprehensive analysis of neural networks
Yuji Yamauchi, Kyoto University
2:45 PM - 3:45 PM

Nutrition and metabolism

NAD+ flux and resiliency in aged mice
Melanie R. McReynolds, Pennsylvania State University Chair
Regulation of mitochondrial calcium transport by caloric restriction in rat kidney
Julian Cualcialpud Serna, Universidade de São Paulo
Sex, dietary pH and protein-dependent effects in diet-induced obese mice
Kalhara Rashmikumara Menikdiwela, Texas Tech University
Sexually dimorphic metabolic effects of a naturally occurring flavonoid are mediated by changes in the gut microbiome.
Priyanka Sharma, Rutgers University
2:45 PM - 3:45 PM

Membrane architecture

Acute manipulation of outer membrane phospholipid composition directly alters mitochondrial dynamics and ultrastructure
Joshua Pemberton, Eunice Kennedy Shriver National Institute of Child Health and Human Development Chair
Lipid expansion microscopy
Brittany Marie White–Mathieu, Cornell University
How lipids regulate the cell surface localization of HSPA1A, a stress-inducible 70-kDa heat shock protein
Rachel Taylor Altman, California State University, Fullerton
Interactions between the aNT domains of human V-ATPases and phosphatidylinositol phosphate lipids
Connie Mitra, SUNY Upstate Medical University
2:45 PM - 3:45 PM

Recent advances in glycobiology

Serial crystallography and kinetics reveal how the FimH bacterial lectin tweaks between mono- and multivalent binding of high-mannose N-glycans
Julie Maria Jozefa Bouckaert, UGSF, CNRS Chair
Identifying mucus-degrading microbes within the human gut microbiota
Janiece Sharmell Glover, Medical University of South Carolina
O-GlcNAc characterization during Tribolium castaneum development
Bruno da Costa Rodrigues, Federal University of Rio de Janeiro
Longitudinal profiling of the plasma glycome from normal and Alzheimer's disease individuals
Bryson Phillip Arnett, University of Kentucky
4:00 PM - 5:00 PM

Spotlight Sessions

Oral presentations selected from volunteer abstracts.

4:00 PM - 5:00 PM

Transcriptional mechanisms, regulation and RNA polymerases

Kinetic networks identify key regulatory nodes and transcription factor functions in early adipogenesis
Michael J. Guertin, University of Connecticut Chair
Measuring the precise position of transitions in transcription with PRO-IP-seq
Philip Versluis, Cornell University
Structural studies of an androgen receptor complex reveal modes of allosteric regulation
Elizabeth Victorina Wasmuth, Memorial Sloan Kettering Cancer Center
Spt5-nucleic acid interactions are directly involved in promoter proximal pausing of RNA polymerase II
Roberta Dollinger, Pennsylvania State University
4:00 PM - 5:00 PM

Protein structure and biophysics

Structural Basis of Nanobody Induced ACKR3 Inhibition
Roman Schlimgen, Medical College of Wisconsin
Domain-swapped dimeric γ-crystallin: the missing link in the evolution of oligomeric β-crystallins
David C. Thorn, Harvard University Chair
Structural studies reveal unique features of nsp16 from SARS-CoV-2, a protein essential for immune system evasion and a possible drug target
Monica Rosas–Lemus, Northwestern University
19F-NMR shows that active site aromatic residues in CYP121 of Mycobacterial tuberculosis play a dual role in substrate interaction and protein structure
Christopher S. Campomizzi, SUNY University at Buffalo
4:00 PM - 5:00 PM

Genomics, glycomics, proteomics and metabolomics

eDNA analysis of goat-grazed rhamnus cathartica soil microbial communities
Paula Soneral, Bethel University
Structure-based computational modeling of germline PTEN mutations in cancer and autism risk: implications for therapeutic targeting
Iris Nira Smith, Cleveland Clinic
Alterations in hepatic albumin phosphorylation in patients with alcohol-associated hepatitis and cirrhosis
Josiah Hardesty, University of Louisville Chair
4:00 PM - 5:00 PM

Tumor biochemistry

Nitration of Hsp90 affects its spatial distribution and promotes schwannoma cell proliferation
Isabelle Elena Logan, Oregon State University Chair
Mechanistic insights into the hypermethylation of BRCA1 evinces a novel pathway to breast tumorigenesis
Dipyaman Patra, Rajiv Gandhi Centre for Biotechnology
Functional characterization of germline and cancer-specific protein MAGEB2
Carlan V. Romney, Fisk University
IL32 overexpression is driven by DNA hypomethylation and contributes to an extracellular matrix (ECM) remodeling phenotype in EpCAM-/CD49f-enriched breast cancer cells
Elayne M. Benson, Presbyterian College
4:00 PM - 5:00 PM

Immune signaling

Dopamine D2-like receptor signaling and downregulation of filamin-A may drive the association between neighborhood socioeconomic status and CCR2 expression on monocytes
Mario A. Pita, National Heart, Lung, and Blood Institute
Insulin-like growth factor 1 induces a reparative neutrophil phenotype
Sophia Reidel, University Hospital of Düsseldorf Chair
Development of an in vitro bioassay to assess the regulation of immune genes in nontraditional model species.
Sarah Bradshaw, North Carolina State University
Effects of dibutyltin exposures on translation regulatory factors eIF4E, eIF4B and S6 in human immune cells
Amanda Ruff, Tennessee State University
4:00 PM - 5:00 PM

Microbiome interactions

Dietary cholesterol-induced gut microbes drive nonalcoholic fatty liver disease pathogenesis in a murine model
Jake Brenner Hermanson, University of Wisconsin–Madison Chair
Alterations in microbiota-gut-brain axis and susceptibility or resilience to traumatic stress
Arax Tanelian, New York Medical College
Fluoropyrimidine bioactivation and metabolism by the gut microbiome
Benjamin G. Horst Guthrie, University of California, San Francisco
Changes in Icelandic soil microbiomes from the forefield of retreating glaciers revealed by Illumina and MinION sequencing
Emmett Smith, Earlham College
4:00 PM - 5:00 PM

Obesity metabolism

Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics
Hahn Nahmgoong, Seoul National University
Pharmacologic or genetic PDE4 inactivation reduces obesity and improves glucose handling in mice
Daniel Irelan, University of South Alabama College of Medicine Chair
Hepatic Stearoyl-CoA desaturase deficiency-mediated induction of the insulin-like growth factor-binding protein 1 requires FGF21
Ayren Ambreyelle McGahee, University of Wisconsin–Madison
Real time measurement of hepatic β-oxidation with deuterium magnetic resonance in murine models on a high fat diet
Marc Mcleod, University of Florida
4:00 PM - 5:00 PM

Lipid synthesis and metabolism

Regulation of sphingomyelin synthesis by cholesterol
Yeongho Kim, Yale University School of Medicine Chair
Probing the central role of phosphatidylinositol synthesis in lipid metabolism of eukaryotic cells
Amrita Mandal, National Institutes of Health
Role of intestinal stearoyl-CoA desaturase 1 in whole-body lipid metabolism and metabolic health
Natalie Burchat, Rutgers University
Amino acid metabolism controls fatty acid structure in Staphylococcus aureus
Sarah G. Whaley, St. Jude Children's Research Hospital