Quantitative metabolism in health and disease
Metabolism is at the basis of every biological process, yet we tend to think about metabolic processes as something that occurs in isolated cells when they are challenged with different media. In the past few decades we have learned a lot in the clinic and from in vitro experiments. With genetic makeup playing such a crucial role in the metabolic capacity of cells and organs during health and disease, the last two decades have been critical to our understanding of metabolism in the context of whole organisms. In this session we will highlight different aspects of how metabolism interfaces with molecular mechanisms to influence functions of different cells and organs in the context of an organism. We focus on quantitative approaches exploring the contributions of metabolic demands to health and disease.
Organizers
Charles Burant, University of Michigan
Gary J. Patti, Washington University in St. Louis
Tânia Reis, University of Colorado, Anschutz Medical Campus
Symposia
Here's a curated list of sessions you might also find interesting. More information will be available in the lead-up to the meeting, so sign up for email updates to stay informed.
Deep dives
Start each day with inspiring plenary sessions on cutting-edge science, then dive deeper into each topic throughout the day.
Racing the clock: Molecular mechanisms of aging
Investigating biochemical aspects of aging both in model organisms and humans.
Plenary speaker Meng Wang, Baylor College of Medicine/HHMI
Is anyone there? Information transfer in biology from proteins to organisms
Looking at how life has evolved to sense chemical and physical signals and change the responses of individual proteins or the behaviors of whole animals.
Plenary speaker Eric Betzig, University of California, Berkeley
I, biochemist: Automation & AI in the lab
How new computational and robotic technologies can help drive biochemistry in unexpected directions.
Plenary speaker Tanja Kortemme, University of California, San Francisco
Inspiring talks
Hear from leading researchers, innovators, pioneers and emerging scientists across all parts of the field.
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Keynote
Wesley Sundquist, University of Utah
Phosphatidic acid phosphatase in lipid regulation: mechanistic insights and therapeutic potential
George Carman, Rutgers University
Finding and building your community: Go further together
Pamela Mertz, St. Mary’s College of Maryland
Exploiting vulnerable biology for malaria drug discovery
Margaret Phillips, University of Texas Southwestern Medical Center
Pathways to persistence: Defining and building excellence in science
Donita C. Brady, University of Pennsylvania Perelman School of Medicine
Canonical and non-canonical signal transduction by JNK
Roger J. Davis, University of Massachusetts Chan Medical School
Structural bioinformatics and protein structure prediction at multiple scales
Roland L. Dunbrack, Jr., Fox Chase Cancer Center
Building the next generation of molecular bioscientists through sustained leadership beyond the bench
Suzanne Barbour, Duke University
Unearthing the lanthanome for rare-earth separations
Joseph A. Cotruvo, Jr., Pennsylvania State University
Guardians of the membrane: Cellular strategies to prevent lipid peroxidation and ferroptosis
James Olzmann, University of California, Berkeley
Kim Orth, University of Texas Southwestern Medical Center
Intra-lysosomal lipid metabolism and neurodegeneration
Monther Abu–Remaileh, Stanford University
New directions
Mini-symposia
Mini-symposia that may be of interest include:
- Alternative grading: practice and research
- Beyond cholesterol: Structure, signaling and nuclear receptors
- Cell death in immunity and inflammation: mechanisms, crosstalk and therapeutic potential
- Clinical variants of protein phosphatases define new disease mechanisms
- Coding and AI education in biochemistry and molecular biology
- Computational biology and AI in cardiometabolic disease etiology and medicine
- Current developments in genome organization and expression
- Decoding enzyme mechanisms in epitranscriptome regulation
- Discovering and deciphering drugs in the membrane
- Interconnected post-translational modifications in neurodegenerative disorder: Crosstalk between arginylation, citrullination, and acetylation in neuronal compartments
- Membrane and organelle dynamics
- Recent advances in protein methyltransferase research: From mechanisms to therapeutics
- Remodeling the cell with AAA-ATPases
- The AI knowledgebase transformation: How large language models and AI are reshaping the future of biological discovery
- The Hippo signaling pathway in health and disease
Emerging investigator seminar
Engage with some of the most impressive research being done by graduate students and postdocs at this full-day seminar.
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Biochemical modifications in health and disease
This session will explore the latest insights into how biochemical modifications shape physiology and pathology, highlighting innovative research and therapeutic opportunities at the interface of chemistry, biology and translational research.
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Lipids in cell–cell communication and metabolism in health and disease
This session will explore the multifaceted roles of lipids in coordinating metabolic networks, signaling pathways and intercellular interactions that underpin health and drive disease.
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Single cell proteomics: from method development to biological and clinical insights
This session will highlight recent advances in mass spectrometry, microfluidics, sample preparation and computational analyses that are rapidly expanding the field's sensitivity and throughput, opening new avenues in systems biology, immunology, cancer research and beyond.
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Professional development
Career and education fair
Discover career opportunities in cutting-edge fields across academia and industry.
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Meetups
Get together with people who have research interests and passions similar to yours during themed meetups.