Meetings & Events

The Havel Lecture

Richard Havel

The Havel Lecture was named after Dr. Richard J. Havel (1925–2016), a pioneer in the fields of lipid metabolism, plasma lipoprotein metabolism and cardiovascular disease. Dr. Havel, who everyone knew as “Dick,” was frequently called “Mr. Lipoprotein USA” because of his groundbreaking work in characterizing distinct classes of lipoproteins and unraveling mechanisms underlying plasma lipoprotein metabolism. As a clinical associate with Christian Anfinsen at the National Institute of health (1953–1956), Dick published landmark papers on plasma lipoprotein metabolism. One of those papers, “The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum,” published in The Journal of Clinical Investigation in 1955, is one of the most frequently cited papers in biomedical research. In another landmark paper, Dick described lipoprotein lipase deficiency as a cause of familial chylomicronemia; that paper was the first description of an inherited disorder of plasma lipoprotein metabolism.

Dick published over 300 manuscripts. The quality of his publications is reflected by his election to the National Academy of Sciences in 1983, the Institute of Medicine in 1989, and the American Academy of Arts and Sciences in 1992. He received many other honors, including the Bristol-Myers Squibb Award for Distinguished Achievement in Nutrition Research and the Distinguished Achievement Award from the American Heart Association’s Council on Arteriosclerosis.

Dick was one of the founders of the Journal of Lipid Research and served as chair of the JLR Advisory Board for many years. From 1973 to 1992, he served as director of UCSF’s Cardiovascular Research Institute, where he trained numerous postdoctoral researchers and mentored junior faculty in biomedical research. Many of Dick’s trainees went on to become outstanding investigators and teachers.

For many years, Dick organized the Deuel Conference on Lipids, which held its first meeting in the mid-1950’s. Dick attended the Deuel Conference every year and continued to attend the meeting for more than 20 years after his retirement from UCSF. Dick typically sat in the front row, often rocking forward in his seat, listening intently, and taking notes on each presentation. He asked penetrating questions and was invariably constructive. As a tribute to Dick’s leadership and his extraordinary record of discovery in lipid metabolism, the Deuel Conference on Lipids instituted an annual Richard J. Havel lectureship. The inaugural Havel lecture was delivered by Drs. Michael Brown and Joseph Goldstein (1995 Nobel laureates in Medicine or Physiology) on March 6, 2002. Since then, the Havel Lecture has been the centerpiece of the Deuel Conference on Lipids.

Past Havel lectures

Jennifer Lippincott-Schwartz

2020

  • Jennifer Lippincott-Schwartz

Dynamics of membrane trafficking, sorting and compartmentalization within eukaryotic cells

Jake Lusis

2019

  • Jake Lusis

The power of natural variation: Sex differences and mitochondrial functions

Michael Czech

2018

  • Michael Czech

Crosstalk between fat metabolism and neuronal signaling

Peter Tontonoz

2017

  • Peter Tontonoz

Transcriptional control of lipid metabolism in physiology and disease

Stephen O'Rahilly

2016

  • Sir Stephen O'Rahilly

Obesity and insulin resistance; lessons from human genetics

Thomas Sudhof

2015

  • Thomas Sudhof

Brown & Goldstein-inspired science off field: Lipid membrane fusion at the synapse

Rudolf Zechner

2014

  • Rudolf Zechner

Lipolysis — more than just the breakdown of fat

Rick Lifton

2013

  • Rick Lifton

From human genetics to validated therapeutic targets

Gokhan Hotamisligil

2012

  • Gokhan Hotamisligil

Inflammation, endoplasmic reticulum stress and lipids: Emerging networks regulating metabolism

Christopher Glass

2011

  • Christopher K. Glass

Oxysterol regulation of macrophage gene expression

David Mangelsdorf

2010

  • David J. Mangelsdorf

Nuclear receptor control of lipid metabolism

Stephen Young

2009

  • Stephen G. Young

Adventures in lipid metabolism

Helen Hobbs

2008

  • Helen H. Hobbs

Going to extrames to identify genetic variations contributing to cardiovascular risk

Ronald Evans

2007

  • Ronald Evans

PPARdelta and the Marathon Mouse: Running around physiolog

David Russell

2006

  • David Russell

The enzymes of cholesterol breakdown

Johann Deisenhofer

2005

  • Johann Deisenhofer

Structure of the LDL receptor

Jeffrey Friedman

2004

  • Jeffrey M. Friedman

Oxysterol regulation of macrophage gene expression

Bruce Spiegelman

2003

  • Bruce Spiegelman

Transcriptional control of energy and glucose metabolism

Michael Brown
Joseph Goldstein

2002

  • Michael S. Brown and Joseph L. Goldstein

SREBPs: Master regulators of lipid metabolism